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Considerations for the Use of a Weak Magnetic Field Generator in Radiation Therapy
Considerations for the Use of a Weak Magnetic Field Generator in Radiation Therapy
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202104658
- ISBN
- 9798293832378
- DDC
- 614
- 서명/저자
- Considerations for the Use of a Weak Magnetic Field Generator in Radiation Therapy
- 발행사항
- [Sl] : University of California, Los Angeles, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 153 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-03, Section: B.
- 주기사항
- Advisor: Low, Daniel Abraham.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Los Angeles, 2025.
- 초록/해제
- 요약Radiation therapy remains a cornerstone in cancer treatment, yet its effectiveness is limited by inherent tumor radioresistance, particularly under hypoxic conditions. Hypoxia significantly reduces radiosensitivity, posing substantial challenges in treating aggressive tumors. Weak magnetic fields (WMFs) present a novel adjunctive strategy with the potential to modulate cellular radiosensitivity, thereby enhancing therapeutic outcomes in radiation oncology.This dissertation aimed to systematically evaluate the biological, dosimetric, and technical considerations required for the clinical integration of a Weak Magnetic Field Generator System (WMFGS) into radiation therapy. Specific Aim 1 investigated the radiobiological effects of WMFs on human pancreatic cancer cells under varying oxygenation states using clonogenic assays. Specific Aim 2 evaluated whether the physical constraints imposed by the WMFGS compromised clinical treatment quality through comprehensive dosimetric analyses of glioblastoma multiforme (GBM), prostate cancer, and lung cancer treatment plans. Specific Aim 3 rigorously assessed the impact of the WMFGS on linear accelerator (linac) performance and clinical dose delivery accuracy according to standardized protocols.Key findings demonstrated that WMF exposure selectively enhanced radiosensitivity under hypoxic conditions while providing modest radioprotection under normoxia, indicating significant potential for therapeutic benefit in hypoxic tumors. Dosimetric analyses revealed that the WMFGS-imposed gantry angle constraints did not compromise clinical treatment quality, demonstrating clinically equivalent treatment coverage and acceptable organ-at-risk doses. Furthermore, technical evaluations showed that the presence and operation of the WMFGS had negligible impact on linac performance, photon beam profiles, and dose distribution accuracy, confirming its operational safety and robustness. The results collectively underscore the significant promise of incorporating weak magnetic fields into clinical radiation therapy, particularly for overcoming hypoxia-induced radioresistance. Future research directions include expanding radiobiological investigations to additional cancer models, enhancing device design for improved clinical flexibility, and initiating clinical trials to translate these promising preclinical findings into clinical practice. Ultimately, this research establishes a strong foundation for future exploration and clinical integration of WMFs, potentially transforming radiation oncology treatment paradigms.
- 일반주제명
- Health sciences
- 일반주제명
- Biophysics
- 일반주제명
- Electromagnetics
- 일반주제명
- Electrical engineering
- 키워드
- Cancer
- 키워드
- Magnetic fields
- 키워드
- Medical physics
- 키워드
- Oncology
- 기타저자
- University of California, Los Angeles Physics and Biology in Medicine 009Y
- 기본자료저록
- Dissertations Abstracts International. 87-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520260202104658
■006m o d
■007cr#unu||||||||
■020 ▼a9798293832378
■035 ▼a(MiAaPQ)AAI32116014
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a614
■1001 ▼aNaumann, Louise Maria.
■24510▼aConsiderations for the Use of a Weak Magnetic Field Generator in Radiation Therapy
■260 ▼a[Sl]▼bUniversity of California, Los Angeles▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a153 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-03, Section: B.
■500 ▼aAdvisor: Low, Daniel Abraham.
■5021 ▼aThesis (Ph.D.)--University of California, Los Angeles, 2025.
■520 ▼aRadiation therapy remains a cornerstone in cancer treatment, yet its effectiveness is limited by inherent tumor radioresistance, particularly under hypoxic conditions. Hypoxia significantly reduces radiosensitivity, posing substantial challenges in treating aggressive tumors. Weak magnetic fields (WMFs) present a novel adjunctive strategy with the potential to modulate cellular radiosensitivity, thereby enhancing therapeutic outcomes in radiation oncology.This dissertation aimed to systematically evaluate the biological, dosimetric, and technical considerations required for the clinical integration of a Weak Magnetic Field Generator System (WMFGS) into radiation therapy. Specific Aim 1 investigated the radiobiological effects of WMFs on human pancreatic cancer cells under varying oxygenation states using clonogenic assays. Specific Aim 2 evaluated whether the physical constraints imposed by the WMFGS compromised clinical treatment quality through comprehensive dosimetric analyses of glioblastoma multiforme (GBM), prostate cancer, and lung cancer treatment plans. Specific Aim 3 rigorously assessed the impact of the WMFGS on linear accelerator (linac) performance and clinical dose delivery accuracy according to standardized protocols.Key findings demonstrated that WMF exposure selectively enhanced radiosensitivity under hypoxic conditions while providing modest radioprotection under normoxia, indicating significant potential for therapeutic benefit in hypoxic tumors. Dosimetric analyses revealed that the WMFGS-imposed gantry angle constraints did not compromise clinical treatment quality, demonstrating clinically equivalent treatment coverage and acceptable organ-at-risk doses. Furthermore, technical evaluations showed that the presence and operation of the WMFGS had negligible impact on linac performance, photon beam profiles, and dose distribution accuracy, confirming its operational safety and robustness. The results collectively underscore the significant promise of incorporating weak magnetic fields into clinical radiation therapy, particularly for overcoming hypoxia-induced radioresistance. Future research directions include expanding radiobiological investigations to additional cancer models, enhancing device design for improved clinical flexibility, and initiating clinical trials to translate these promising preclinical findings into clinical practice. Ultimately, this research establishes a strong foundation for future exploration and clinical integration of WMFs, potentially transforming radiation oncology treatment paradigms.
■590 ▼aSchool code: 0031.
■650 4▼aHealth sciences
■650 4▼aBiophysics
■650 4▼aElectromagnetics
■650 4▼aElectrical engineering
■653 ▼aCancer
■653 ▼aMagnetic fields
■653 ▼aMedical physics
■653 ▼aOncology
■653 ▼aRadiation therapy
■690 ▼a0566
■690 ▼a0786
■690 ▼a0544
■690 ▼a0607
■71020▼aUniversity of California, Los Angeles▼bPhysics and Biology in Medicine 009Y.
■7730 ▼tDissertations Abstracts International▼g87-03B.
■790 ▼a0031
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17358414▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
