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Molecular and Clinical Epidemiologic Investigations of Infections Caused by Uropathogenic Escherichia coli
Molecular and Clinical Epidemiologic Investigations of Infections Caused by Uropathogenic Escherichia coli
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105114
- ISBN
- 9798297601727
- DDC
- 576
- 서명/저자
- Molecular and Clinical Epidemiologic Investigations of Infections Caused by Uropathogenic Escherichia coli
- 발행사항
- [Sl] : University of California, Berkeley, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 112 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-04, Section: B.
- 주기사항
- Advisor: Graham, Jay P.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Berkeley, 2025.
- 초록/해제
- 요약Antimicrobial resistance (AMR) is a major threat to public health, as AMR infections are more difficult to treat, are more likely to lead to complications, and have been increasing in prevalence. AMR infections are estimated to have contributed to 4.95 million deaths in 2009 alone.1 Emergence of extended spectrum beta-lactamase (ESBL) producing bacteria, primarily E. coli, are particularly concerning because they are resistant to several classes of antibiotics, including some last-line antibiotics, third-generation cephalosporins. Urinary tract infections (UTI) are an important focus for AMR research, as one of the most common bacterial infections. The majority of UTIs are caused by uropathogenic E. coli (UPEC) in both community and healthcare settings. E. coli are incredibly diverse and readily share plasmids, aiding in the dissemination of AMR genes. Surveillance of UPEC to prevent and diagnose AMR infections is thus an important component of the fight against AMR.The work presented here leverages genomic and epidemiologic methods to address two issues related to AMR infection surveillance. The first chapter provides an introduction to the complexity of AMR and UPEC. The second chapter uses publicly available whole-genome sequence data to develop a rapid, inexpensive assay for identifying common UPEC sequence types, to aid in future epidemiologic surveillance for the control of UPEC. The third, uses electronic health record data to evaluate the risk of developing complications from a community onset UTI caused by ESBL-producing E. coli, emphasizing the importance of early detection and monitoring of ESBL infections.
- 일반주제명
- Microbiology
- 일반주제명
- Epidemiology
- 일반주제명
- Public health
- 키워드
- Escherichia coli
- 기타저자
- University of California, Berkeley Infectious Diseases & Immunity
- 기본자료저록
- Dissertations Abstracts International. 87-04B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■006m o d
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■020 ▼a9798297601727
■035 ▼a(MiAaPQ)AAI32237343
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a576
■1001 ▼aMastrangelo, Claire Frances.
■24510▼aMolecular and Clinical Epidemiologic Investigations of Infections Caused by Uropathogenic Escherichia coli
■260 ▼a[Sl]▼bUniversity of California, Berkeley▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a112 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-04, Section: B.
■500 ▼aAdvisor: Graham, Jay P.
■5021 ▼aThesis (Ph.D.)--University of California, Berkeley, 2025.
■520 ▼aAntimicrobial resistance (AMR) is a major threat to public health, as AMR infections are more difficult to treat, are more likely to lead to complications, and have been increasing in prevalence. AMR infections are estimated to have contributed to 4.95 million deaths in 2009 alone.1 Emergence of extended spectrum beta-lactamase (ESBL) producing bacteria, primarily E. coli, are particularly concerning because they are resistant to several classes of antibiotics, including some last-line antibiotics, third-generation cephalosporins. Urinary tract infections (UTI) are an important focus for AMR research, as one of the most common bacterial infections. The majority of UTIs are caused by uropathogenic E. coli (UPEC) in both community and healthcare settings. E. coli are incredibly diverse and readily share plasmids, aiding in the dissemination of AMR genes. Surveillance of UPEC to prevent and diagnose AMR infections is thus an important component of the fight against AMR.The work presented here leverages genomic and epidemiologic methods to address two issues related to AMR infection surveillance. The first chapter provides an introduction to the complexity of AMR and UPEC. The second chapter uses publicly available whole-genome sequence data to develop a rapid, inexpensive assay for identifying common UPEC sequence types, to aid in future epidemiologic surveillance for the control of UPEC. The third, uses electronic health record data to evaluate the risk of developing complications from a community onset UTI caused by ESBL-producing E. coli, emphasizing the importance of early detection and monitoring of ESBL infections.
■590 ▼aSchool code: 0028.
■650 4▼aMicrobiology
■650 4▼aEpidemiology
■650 4▼aPublic health
■653 ▼aAntimicrobial resistance
■653 ▼aEscherichia coli
■653 ▼aUrinary tract infections
■653 ▼aElectronic health record
■653 ▼aBacterial infections
■690 ▼a0410
■690 ▼a0766
■690 ▼a0573
■71020▼aUniversity of California, Berkeley▼bInfectious Diseases & Immunity.
■7730 ▼tDissertations Abstracts International▼g87-04B.
■790 ▼a0028
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359405▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
