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Mechanisms of Contextual Modulation in Primary Visual Cortex
Mechanisms of Contextual Modulation in Primary Visual Cortex
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202104705
- ISBN
- 9798290909684
- DDC
- 616
- 서명/저자
- Mechanisms of Contextual Modulation in Primary Visual Cortex
- 발행사항
- [Sl] : University of Minnesota, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 147 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-01, Section: B.
- 주기사항
- Advisor: Olman, Cheryl;Sederberg, Audrey.
- 학위논문주기
- Thesis (Ph.D.)--University of Minnesota, 2025.
- 초록/해제
- 요약Visual perception depends critically on the brain's ability to integrate information across spatial context. In this thesis, I examine the circuit mechanisms by which primary visual cortex (V1) implements flexible normalization to modulate local feature representations based on surrounding stimuli. I address three interrelated questions: (1) What are the cortical origins of orientation-dependent and figure-ground contextual signals in V1? (2) How do network oscillations reflect and constrain mechanistic models of contextual modulation? (3) Can a biologically grounded model of E-I circuitry reproduce empirical signatures of orientation selectivity in V1?In Chapter 2, I employ ultra-high-field laminar fMRI in human V1 to disentangle feedforward and feedback contributions to contextual modulation, revealing depth-specific BOLD profiles for distinct forms of surround influence. Chapter 3 analyzes the orientation tilt illusion and neural oscillations measured from LFP, demonstrating that contextual effects leading to altered perceptions of orientation and leading to changes in narrow-band gamma oscillations can both be explained with a biologically plausible implementation of divisive normalization. In Chapter 4, I use a stabilized supralinear network (SSN) to explore mechanisms of orientation selectivity in ferret V1 by directly comparing model predictions to single-cell measurements from two-photon calcium imaging. Together, this work bridges multiple spatial scales from synaptic circuits through population dynamics to cortical interactions across the visual hierarchy and advances our understanding of how recurrent and feedforward interactions implement context-dependent computations in visual cortex.
- 일반주제명
- Neurosciences
- 일반주제명
- Physiology
- 일반주제명
- Health sciences
- 기타저자
- University of Minnesota Neuroscience
- 기본자료저록
- Dissertations Abstracts International. 87-01B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■006m o d
■007cr#unu||||||||
■020 ▼a9798290909684
■035 ▼a(MiAaPQ)AAI32116819
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aEmerson, Joseph Harris.
■24510▼aMechanisms of Contextual Modulation in Primary Visual Cortex
■260 ▼a[Sl]▼bUniversity of Minnesota▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a147 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-01, Section: B.
■500 ▼aAdvisor: Olman, Cheryl;Sederberg, Audrey.
■5021 ▼aThesis (Ph.D.)--University of Minnesota, 2025.
■520 ▼aVisual perception depends critically on the brain's ability to integrate information across spatial context. In this thesis, I examine the circuit mechanisms by which primary visual cortex (V1) implements flexible normalization to modulate local feature representations based on surrounding stimuli. I address three interrelated questions: (1) What are the cortical origins of orientation-dependent and figure-ground contextual signals in V1? (2) How do network oscillations reflect and constrain mechanistic models of contextual modulation? (3) Can a biologically grounded model of E-I circuitry reproduce empirical signatures of orientation selectivity in V1?In Chapter 2, I employ ultra-high-field laminar fMRI in human V1 to disentangle feedforward and feedback contributions to contextual modulation, revealing depth-specific BOLD profiles for distinct forms of surround influence. Chapter 3 analyzes the orientation tilt illusion and neural oscillations measured from LFP, demonstrating that contextual effects leading to altered perceptions of orientation and leading to changes in narrow-band gamma oscillations can both be explained with a biologically plausible implementation of divisive normalization. In Chapter 4, I use a stabilized supralinear network (SSN) to explore mechanisms of orientation selectivity in ferret V1 by directly comparing model predictions to single-cell measurements from two-photon calcium imaging. Together, this work bridges multiple spatial scales from synaptic circuits through population dynamics to cortical interactions across the visual hierarchy and advances our understanding of how recurrent and feedforward interactions implement context-dependent computations in visual cortex.
■590 ▼aSchool code: 0130.
■650 4▼aNeurosciences
■650 4▼aPhysiology
■650 4▼aHealth sciences
■653 ▼aContextual modulation
■653 ▼aDivisive normalization
■653 ▼aFigure-ground modulation
■653 ▼aOrientation-tuned surround suppression
■653 ▼aPrimary visual cortex
■653 ▼aRecurrent neural network
■690 ▼a0317
■690 ▼a0566
■690 ▼a0719
■71020▼aUniversity of Minnesota▼bNeuroscience.
■7730 ▼tDissertations Abstracts International▼g87-01B.
■790 ▼a0130
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17358455▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
