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Computational Imaging System for Volumetric and Hyperspectral Microscopy
Computational Imaging System for Volumetric and Hyperspectral Microscopy
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105645
- ISBN
- 9798270225094
- DDC
- 535
- 저자명
- Zhao, Ruixuan.
- 서명/저자
- Computational Imaging System for Volumetric and Hyperspectral Microscopy
- 발행사항
- [Sl] : University of California, Los Angeles, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 95 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-06, Section: B.
- 주기사항
- Advisor: Emaminejad, Sam S. E.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Los Angeles, 2025.
- 초록/해제
- 요약Computational imaging has rapidly advanced with improvements in optical instrumentation and computational power. A key goal of this field is to capture the complete plenoptic function-a seven-dimensional representation of light spanning 3D space (x, y, z), time (t), wavelength (λ), and angular directions (u, v). Conventional imaging systems, which record only 2D spatial intensity, overlook most of this information, leading to inefficient data acquisition and limited reconstruction of high-dimensional scenes.This dissertation presents a series of computational imaging approaches that jointly leverage optical encoding and computational decoding to achieve high-dimensional, snapshot imaging. First, for high-speed volumetric imaging, we introduce Squeezed Light Field Microscopy (SLIM) and Confocal SLIM. Using a customized anamorphic relay to compress the light field onto a reduced camera region of interest, SLIM achieves kilohertz-rate volumetric imaging (1,000 volumes per second). This enables millisecond-scale capture of fast biological dynamics such as 3D blood flow and neural voltage activity. Second, for snapshot hyperspectral imaging, we integrate a Coded Aperture Snapshot Spectral Imaging (CASSI) module into a fundus imaging system. Experiments on standard targets, eye phantoms, and in vivo human retinas validate the system's spectral fidelity and potential for noninvasive clinical diagnostics. Finally, for 5D hyperspectral volumetric imaging, we propose Coded Aperture Snapshot Hyperspectral Light Field Tomography (CASH-LIFT), a cascaded compressed-sensing scheme that efficiently reconstructs dynamic 5D datacubes over large spatial and spectral ranges. Together, these approaches demonstrate how co-designing optical hardware and computational algorithms can dramatically expand the dimensionality, speed, and efficiency of optical imaging-paving the way for next-generation tools in neuroscience, ophthalmology, and biomedical research.
- 일반주제명
- Optics
- 일반주제명
- Computational physics
- 일반주제명
- Bioengineering
- 일반주제명
- Medical imaging
- 키워드
- Microscopy
- 키워드
- Optical imaging
- 기타저자
- University of California, Los Angeles Electrical and Computer Engineering 0333
- 기본자료저록
- Dissertations Abstracts International. 87-06B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520260202105645
■006m o d
■007cr#unu||||||||
■020 ▼a9798270225094
■035 ▼a(MiAaPQ)AAI32400255
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a535
■1001 ▼aZhao, Ruixuan.
■24510▼aComputational Imaging System for Volumetric and Hyperspectral Microscopy
■260 ▼a[Sl]▼bUniversity of California, Los Angeles▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a95 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-06, Section: B.
■500 ▼aAdvisor: Emaminejad, Sam S. E.
■5021 ▼aThesis (Ph.D.)--University of California, Los Angeles, 2025.
■520 ▼aComputational imaging has rapidly advanced with improvements in optical instrumentation and computational power. A key goal of this field is to capture the complete plenoptic function-a seven-dimensional representation of light spanning 3D space (x, y, z), time (t), wavelength (λ), and angular directions (u, v). Conventional imaging systems, which record only 2D spatial intensity, overlook most of this information, leading to inefficient data acquisition and limited reconstruction of high-dimensional scenes.This dissertation presents a series of computational imaging approaches that jointly leverage optical encoding and computational decoding to achieve high-dimensional, snapshot imaging. First, for high-speed volumetric imaging, we introduce Squeezed Light Field Microscopy (SLIM) and Confocal SLIM. Using a customized anamorphic relay to compress the light field onto a reduced camera region of interest, SLIM achieves kilohertz-rate volumetric imaging (1,000 volumes per second). This enables millisecond-scale capture of fast biological dynamics such as 3D blood flow and neural voltage activity. Second, for snapshot hyperspectral imaging, we integrate a Coded Aperture Snapshot Spectral Imaging (CASSI) module into a fundus imaging system. Experiments on standard targets, eye phantoms, and in vivo human retinas validate the system's spectral fidelity and potential for noninvasive clinical diagnostics. Finally, for 5D hyperspectral volumetric imaging, we propose Coded Aperture Snapshot Hyperspectral Light Field Tomography (CASH-LIFT), a cascaded compressed-sensing scheme that efficiently reconstructs dynamic 5D datacubes over large spatial and spectral ranges. Together, these approaches demonstrate how co-designing optical hardware and computational algorithms can dramatically expand the dimensionality, speed, and efficiency of optical imaging-paving the way for next-generation tools in neuroscience, ophthalmology, and biomedical research.
■590 ▼aSchool code: 0031.
■650 4▼aOptics
■650 4▼aComputational physics
■650 4▼aBioengineering
■650 4▼aMedical imaging
■653 ▼aComputational imaging
■653 ▼aMicroscopy
■653 ▼aOptical imaging
■653 ▼aFundus imaging system
■690 ▼a0752
■690 ▼a0216
■690 ▼a0202
■690 ▼a0574
■71020▼aUniversity of California, Los Angeles▼bElectrical and Computer Engineering 0333.
■7730 ▼tDissertations Abstracts International▼g87-06B.
■790 ▼a0031
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17360969▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.


