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Computational Imaging System for Volumetric and Hyperspectral Microscopy
Computational Imaging System for Volumetric and Hyperspectral Microscopy
Computational Imaging System for Volumetric and Hyperspectral Microscopy

상세정보

자료유형  
 학위논문 서양
최종처리일시  
20260202105645
ISBN  
9798270225094
DDC  
535
저자명  
Zhao, Ruixuan.
서명/저자  
Computational Imaging System for Volumetric and Hyperspectral Microscopy
발행사항  
[Sl] : University of California, Los Angeles, 2025
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2025
형태사항  
95 p
주기사항  
Source: Dissertations Abstracts International, Volume: 87-06, Section: B.
주기사항  
Advisor: Emaminejad, Sam S. E.
학위논문주기  
Thesis (Ph.D.)--University of California, Los Angeles, 2025.
초록/해제  
요약Computational imaging has rapidly advanced with improvements in optical instrumentation and computational power. A key goal of this field is to capture the complete plenoptic function-a seven-dimensional representation of light spanning 3D space (x, y, z), time (t), wavelength (λ), and angular directions (u, v). Conventional imaging systems, which record only 2D spatial intensity, overlook most of this information, leading to inefficient data acquisition and limited reconstruction of high-dimensional scenes.This dissertation presents a series of computational imaging approaches that jointly leverage optical encoding and computational decoding to achieve high-dimensional, snapshot imaging. First, for high-speed volumetric imaging, we introduce Squeezed Light Field Microscopy (SLIM) and Confocal SLIM. Using a customized anamorphic relay to compress the light field onto a reduced camera region of interest, SLIM achieves kilohertz-rate volumetric imaging (1,000 volumes per second). This enables millisecond-scale capture of fast biological dynamics such as 3D blood flow and neural voltage activity. Second, for snapshot hyperspectral imaging, we integrate a Coded Aperture Snapshot Spectral Imaging (CASSI) module into a fundus imaging system. Experiments on standard targets, eye phantoms, and in vivo human retinas validate the system's spectral fidelity and potential for noninvasive clinical diagnostics. Finally, for 5D hyperspectral volumetric imaging, we propose Coded Aperture Snapshot Hyperspectral Light Field Tomography (CASH-LIFT), a cascaded compressed-sensing scheme that efficiently reconstructs dynamic 5D datacubes over large spatial and spectral ranges. Together, these approaches demonstrate how co-designing optical hardware and computational algorithms can dramatically expand the dimensionality, speed, and efficiency of optical imaging-paving the way for next-generation tools in neuroscience, ophthalmology, and biomedical research.
일반주제명  
Optics
일반주제명  
Computational physics
일반주제명  
Bioengineering
일반주제명  
Medical imaging
키워드  
Computational imaging
키워드  
Microscopy
키워드  
Optical imaging
키워드  
Fundus imaging system
기타저자  
University of California, Los Angeles Electrical and Computer Engineering 0333
기본자료저록  
Dissertations Abstracts International. 87-06B.
전자적 위치 및 접속  
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MARC

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■006m          o    d                
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■020    ▼a9798270225094
■035    ▼a(MiAaPQ)AAI32400255
■040    ▼aMiAaPQ▼cMiAaPQ
■0820  ▼a535
■1001  ▼aZhao,  Ruixuan.
■24510▼aComputational  Imaging  System  for  Volumetric  and  Hyperspectral  Microscopy
■260    ▼a[Sl]▼bUniversity  of  California,  Los  Angeles▼c2025
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2025
■300    ▼a95  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  87-06,  Section:  B.
■500    ▼aAdvisor:  Emaminejad,  Sam  S.  E.
■5021  ▼aThesis  (Ph.D.)--University  of  California,  Los  Angeles,  2025.
■520    ▼aComputational  imaging  has  rapidly  advanced  with  improvements  in  optical  instrumentation  and  computational  power.  A  key  goal  of  this  field  is  to  capture  the  complete  plenoptic  function-a  seven-dimensional  representation  of  light  spanning  3D  space  (x,  y,  z),  time  (t),  wavelength  (λ),  and  angular  directions  (u,  v).  Conventional  imaging  systems,  which  record  only  2D  spatial  intensity,  overlook  most  of  this  information,  leading  to  inefficient  data  acquisition  and  limited  reconstruction  of  high-dimensional  scenes.This  dissertation  presents  a  series  of  computational  imaging  approaches  that  jointly  leverage  optical  encoding  and  computational  decoding  to  achieve  high-dimensional,  snapshot  imaging.  First,  for  high-speed  volumetric  imaging,  we  introduce  Squeezed  Light  Field  Microscopy  (SLIM)  and  Confocal  SLIM.  Using  a  customized  anamorphic  relay  to  compress  the  light  field  onto  a  reduced  camera  region  of  interest,  SLIM  achieves  kilohertz-rate  volumetric  imaging  (1,000  volumes  per  second).  This  enables  millisecond-scale  capture  of  fast  biological  dynamics  such  as  3D  blood  flow  and  neural  voltage  activity.  Second,  for  snapshot  hyperspectral  imaging,  we  integrate  a  Coded  Aperture  Snapshot  Spectral  Imaging  (CASSI)  module  into  a  fundus  imaging  system.  Experiments  on  standard  targets,  eye  phantoms,  and  in  vivo  human  retinas  validate  the  system's  spectral  fidelity  and  potential  for  noninvasive  clinical  diagnostics.  Finally,  for  5D  hyperspectral  volumetric  imaging,  we  propose  Coded  Aperture  Snapshot  Hyperspectral  Light  Field  Tomography  (CASH-LIFT),  a  cascaded  compressed-sensing  scheme  that  efficiently  reconstructs  dynamic  5D  datacubes  over  large  spatial  and  spectral  ranges.  Together,  these  approaches  demonstrate  how  co-designing  optical  hardware  and  computational  algorithms  can  dramatically  expand  the  dimensionality,  speed,  and  efficiency  of  optical  imaging-paving  the  way  for  next-generation  tools  in  neuroscience,  ophthalmology,  and  biomedical  research.
■590    ▼aSchool  code:  0031.
■650  4▼aOptics
■650  4▼aComputational  physics
■650  4▼aBioengineering
■650  4▼aMedical  imaging
■653    ▼aComputational  imaging
■653    ▼aMicroscopy
■653    ▼aOptical  imaging
■653    ▼aFundus  imaging  system
■690    ▼a0752
■690    ▼a0216
■690    ▼a0202
■690    ▼a0574
■71020▼aUniversity  of  California,  Los  Angeles▼bElectrical  and  Computer  Engineering  0333.
■7730  ▼tDissertations  Abstracts  International▼g87-06B.
■790    ▼a0031
■791    ▼aPh.D.
■792    ▼a2025
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17360969▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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