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Modulation Strategies for Tuning Biomimetic Hydrogel Microstructure and Mechanical Properties
Modulation Strategies for Tuning Biomimetic Hydrogel Microstructure and Mechanical Properties
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105646
- ISBN
- 9798270224936
- DDC
- 620.11
- 저자명
- Du, Yingjie.
- 서명/저자
- Modulation Strategies for Tuning Biomimetic Hydrogel Microstructure and Mechanical Properties
- 발행사항
- [Sl] : University of California, Los Angeles, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 100 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-06, Section: B.
- 주기사항
- Advisor: He, Ximin.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Los Angeles, 2025.
- 초록/해제
- 요약Hydrogels are soft, hydrophilic polymer networks with high water content, porosity, and stimuli-responsive behavior. Due to their biocompatibility and tunable chemical and mechanical properties, hydrogels have been widely adopted in biomedical applications, ranging from contact lenses to wound dressings, soft actuators, biosensors, and drug delivery systems. Their ability to respond to environmental cues such as temperature, pH, and mechanical forces makes them particularly well-suited for tissue engineering and biomedical applications. However, conventional hydrogels still lack the strength, resilience, and nonlinear stress-strain behavior that natural tissues exhibit. Furthermore, they possess an inherent toughness-hysteresis conflict, a phenomenon that limits their ability to expand into many load-bearing applications. In this dissertation, we devise methods to design hydrogels that are able to overcome these drawbacks and become more mechanically compatible with natural cells and tissues.In Chapter 1, we explore the status of hydrogels in biomedical applications regarding current advances in material design and strategies. Chapter 2 introduces existing strategies for crosslinking and modulating hydrogel microstructure and mechanical properties. In Chapter 3, we investigate how intestinal smooth muscle cells behave on scaffolds of varying stiffness and the nature of tissue response under stress. Following this, we explore novel modulation strategies to tune the mechanical properties of hydrogels, thereby overcoming the toughness-hysteresis conflict. Finally, we design an artificial muscle tissue that can be implanted into a rabbit animal model, serving as an extraocular muscle implant. Chapter 4 discusses the conclusion and future outlook on the future work for hydrogels discussed in this dissertation.
- 일반주제명
- Materials science
- 일반주제명
- Engineering
- 키워드
- Biomaterials
- 키워드
- Hydrogels
- 키워드
- Polymers
- 기타저자
- University of California, Los Angeles Materials Science and Engineering 0328
- 기본자료저록
- Dissertations Abstracts International. 87-06B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798270224936
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■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a620.11
■1001 ▼aDu, Yingjie.
■24510▼aModulation Strategies for Tuning Biomimetic Hydrogel Microstructure and Mechanical Properties
■260 ▼a[Sl]▼bUniversity of California, Los Angeles▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a100 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-06, Section: B.
■500 ▼aAdvisor: He, Ximin.
■5021 ▼aThesis (Ph.D.)--University of California, Los Angeles, 2025.
■520 ▼aHydrogels are soft, hydrophilic polymer networks with high water content, porosity, and stimuli-responsive behavior. Due to their biocompatibility and tunable chemical and mechanical properties, hydrogels have been widely adopted in biomedical applications, ranging from contact lenses to wound dressings, soft actuators, biosensors, and drug delivery systems. Their ability to respond to environmental cues such as temperature, pH, and mechanical forces makes them particularly well-suited for tissue engineering and biomedical applications. However, conventional hydrogels still lack the strength, resilience, and nonlinear stress-strain behavior that natural tissues exhibit. Furthermore, they possess an inherent toughness-hysteresis conflict, a phenomenon that limits their ability to expand into many load-bearing applications. In this dissertation, we devise methods to design hydrogels that are able to overcome these drawbacks and become more mechanically compatible with natural cells and tissues.In Chapter 1, we explore the status of hydrogels in biomedical applications regarding current advances in material design and strategies. Chapter 2 introduces existing strategies for crosslinking and modulating hydrogel microstructure and mechanical properties. In Chapter 3, we investigate how intestinal smooth muscle cells behave on scaffolds of varying stiffness and the nature of tissue response under stress. Following this, we explore novel modulation strategies to tune the mechanical properties of hydrogels, thereby overcoming the toughness-hysteresis conflict. Finally, we design an artificial muscle tissue that can be implanted into a rabbit animal model, serving as an extraocular muscle implant. Chapter 4 discusses the conclusion and future outlook on the future work for hydrogels discussed in this dissertation.
■590 ▼aSchool code: 0031.
■650 4▼aMaterials science
■650 4▼aEngineering
■653 ▼aBiomaterials
■653 ▼aHydrogels
■653 ▼aToughness-hysteresis conflict
■653 ▼aMechanical properties
■653 ▼aPolymers
■690 ▼a0794
■690 ▼a0537
■71020▼aUniversity of California, Los Angeles▼bMaterials Science and Engineering 0328.
■7730 ▼tDissertations Abstracts International▼g87-06B.
■790 ▼a0031
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17360973▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
