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Longitudinal Effects of Weight and Physical Activity on Alzheimer's Disease in Down Syndrome
Longitudinal Effects of Weight and Physical Activity on Alzheimer's Disease in Down Syndrome
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105119
- ISBN
- 9798291559444
- DDC
- 618.97
- 서명/저자
- Longitudinal Effects of Weight and Physical Activity on Alzheimers Disease in Down Syndrome
- 발행사항
- [Sl] : The University of Wisconsin - Madison, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 146 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-02, Section: B.
- 주기사항
- Includes supplementary digital materials.
- 주기사항
- Advisor: Hartley, Sigan L.
- 학위논문주기
- Thesis (Ph.D.)--The University of Wisconsin - Madison, 2025.
- 초록/해제
- 요약Despite lifespan increases among individuals with Down syndrome (DS), nearly all will develop Alzheimer's disease (AD). Yet, the timing and mechanisms through which AD risk and protective factors emerge, and the extent to which modifiable lifestyle factors may protect against decline, remain poorly understood. This dissertation investigates the biological and lifestyle correlates of AD progression in adults with DS, with a focus on body mass index (BMI), systemic inflammation, and physical activity.Paper 1 examined longitudinal changes in BMI in relation to AD pathology and cognition. Findings indicated that adults with DS begin to experience BMI decline in their early 40s, with greater decline predicted by early amyloid beta (Aβ) burden and associated with memory decline and increased dementia symptoms. Paper 2 explored associations between obesity, age, Aβ, and systemic inflammation. Results revealed distinct, but overlapping inflammatory markers linked to obesity and aging, whereas Aβ was not robustly associated with systemic inflammation, highlighting the need for neuroinflammatory markers (i.e., YKL40, GFAP) in this population. Paper 3 evaluated whether moderate-to-vigorous physical activity (MVPA) conferred resistance to Aβ burden or resilience to cognitive decline. MVPA did not reduce amyloid accumulation but moderated its impact on cognition (i.e., there was a resilience pathway), such that adults with higher activity levels experienced less cognitive decline despite similar pathology.Together, these studies suggest that BMI decline may be an early indicator of AD in DS, that systemic inflammation is associated with obesity and age, and that physical activity supports cognitive resilience in the face of AD pathology. Findings underscore the importance of monitoring physical health indicators and promoting active lifestyles to improve outcomes for adults with DS as they age.
- 일반주제명
- Aging
- 일반주제명
- Disability studies
- 일반주제명
- Social research
- 일반주제명
- Pathology
- 키워드
- Down syndrome
- 키워드
- Inflammation
- 키워드
- Lifestyle
- 키워드
- Weight
- 기타저자
- The University of Wisconsin - Madison Human Ecology
- 기본자료저록
- Dissertations Abstracts International. 87-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■006m o d
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■020 ▼a9798291559444
■035 ▼a(MiAaPQ)AAI32238205
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a618.97
■1001 ▼aFleming-Batayneh, Victoria L.
■24510▼aLongitudinal Effects of Weight and Physical Activity on Alzheimer's Disease in Down Syndrome
■260 ▼a[Sl]▼bThe University of Wisconsin - Madison▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a146 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-02, Section: B.
■500 ▼aIncludes supplementary digital materials.
■500 ▼aAdvisor: Hartley, Sigan L.
■5021 ▼aThesis (Ph.D.)--The University of Wisconsin - Madison, 2025.
■520 ▼aDespite lifespan increases among individuals with Down syndrome (DS), nearly all will develop Alzheimer's disease (AD). Yet, the timing and mechanisms through which AD risk and protective factors emerge, and the extent to which modifiable lifestyle factors may protect against decline, remain poorly understood. This dissertation investigates the biological and lifestyle correlates of AD progression in adults with DS, with a focus on body mass index (BMI), systemic inflammation, and physical activity.Paper 1 examined longitudinal changes in BMI in relation to AD pathology and cognition. Findings indicated that adults with DS begin to experience BMI decline in their early 40s, with greater decline predicted by early amyloid beta (Aβ) burden and associated with memory decline and increased dementia symptoms. Paper 2 explored associations between obesity, age, Aβ, and systemic inflammation. Results revealed distinct, but overlapping inflammatory markers linked to obesity and aging, whereas Aβ was not robustly associated with systemic inflammation, highlighting the need for neuroinflammatory markers (i.e., YKL40, GFAP) in this population. Paper 3 evaluated whether moderate-to-vigorous physical activity (MVPA) conferred resistance to Aβ burden or resilience to cognitive decline. MVPA did not reduce amyloid accumulation but moderated its impact on cognition (i.e., there was a resilience pathway), such that adults with higher activity levels experienced less cognitive decline despite similar pathology.Together, these studies suggest that BMI decline may be an early indicator of AD in DS, that systemic inflammation is associated with obesity and age, and that physical activity supports cognitive resilience in the face of AD pathology. Findings underscore the importance of monitoring physical health indicators and promoting active lifestyles to improve outcomes for adults with DS as they age.
■590 ▼aSchool code: 0262.
■650 4▼aAging
■650 4▼aDisability studies
■650 4▼aSocial research
■650 4▼aPathology
■653 ▼aAlzheimer's disease
■653 ▼aDown syndrome
■653 ▼aInflammation
■653 ▼aLifestyle
■653 ▼aPhysical activity
■653 ▼aWeight
■690 ▼a0493
■690 ▼a0201
■690 ▼a0344
■690 ▼a0571
■71020▼aThe University of Wisconsin - Madison▼bHuman Ecology.
■7730 ▼tDissertations Abstracts International▼g87-02B.
■790 ▼a0262
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359444▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
