서브메뉴
검색
Are There Sex-Specific Differences in Obesity Treatment Outcomes in the Pediatric Population?
Are There Sex-Specific Differences in Obesity Treatment Outcomes in the Pediatric Population?
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105120
- ISBN
- 9798293866519
- DDC
- 614
- 저자명
- Jang, Su Bin.
- 서명/저자
- Are There Sex-Specific Differences in Obesity Treatment Outcomes in the Pediatric Population?
- 발행사항
- [Sl] : University of Minnesota, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 156 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-03, Section: B.
- 주기사항
- Advisor: Ryder, Justin R.;Sherwood, Nancy E.
- 학위논문주기
- Thesis (Ph.D.)--University of Minnesota, 2025.
- 초록/해제
- 요약The rising prevalence of childhood obesity is a significant public health problem due to the increased risk of developing various comorbid conditions. Children with obesity are likely to still live with obesity in adulthood, which further increases the risk of comorbid conditions. There are several options for obesity interventions, including lifestyle modification, pharmacotherapy, and metabolic and bariatric surgery, with some interventions being very effective. With sex differences in physiological characteristics between males and females, it is possible that they respond differently to obesity interventions; however, the literature on this topic is limited. This dissertation examined sex differences in weight loss responses to lifestyle modification intervention, pharmacotherapy, and metabolic/bariatric surgery among the children and adolescent population. The following manuscripts are secondary data analyses.Manuscript 1 evaluated sex differences in response to lifestyle modification interventions. Two harmonized datasets (family-based intervention and nutrition-focused intervention) were used for the analyses. We found modest sex differences in the family-based intervention, and males lost more weight compared with females in the nutrition-focused intervention.Manuscript 2 assessed sex differences in response to obesity pharmacotherapy. Two high-quality randomized controlled trials (phentermine/topiramate and metformin) were utilized for the analyses. We found modest sex differences in response to either phentermine/topiramate or metformin. We further explored whether the pubertal stage modified the sex differences in response to each pharmacotherapy and observed that it modified the association in the metformin study.Manuscript 3 analyzed sex differences in response to metabolic and bariatric surgery. Four high-quality studies were harmonized into a single dataset. We found that males experienced greater weight loss compared to females.In summary, we found notable sex differences occur in some obesity interventions, but not in others. Understanding whether these sex differences are clinically meaningful in response to various obesity intervention types may guide obesity precision medicine.
- 일반주제명
- Public health
- 일반주제명
- Epidemiology
- 일반주제명
- Pediatrics
- 일반주제명
- Nutrition
- 키워드
- Pharmacotherapy
- 기타저자
- University of Minnesota Epidemiology
- 기본자료저록
- Dissertations Abstracts International. 87-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008260126s2025 us c eng d■001000017359449
■00520260202105120
■006m o d
■007cr#unu||||||||
■020 ▼a9798293866519
■035 ▼a(MiAaPQ)AAI32238286
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a614
■1001 ▼aJang, Su Bin.
■24510▼aAre There Sex-Specific Differences in Obesity Treatment Outcomes in the Pediatric Population?
■260 ▼a[Sl]▼bUniversity of Minnesota▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a156 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-03, Section: B.
■500 ▼aAdvisor: Ryder, Justin R.;Sherwood, Nancy E.
■5021 ▼aThesis (Ph.D.)--University of Minnesota, 2025.
■520 ▼aThe rising prevalence of childhood obesity is a significant public health problem due to the increased risk of developing various comorbid conditions. Children with obesity are likely to still live with obesity in adulthood, which further increases the risk of comorbid conditions. There are several options for obesity interventions, including lifestyle modification, pharmacotherapy, and metabolic and bariatric surgery, with some interventions being very effective. With sex differences in physiological characteristics between males and females, it is possible that they respond differently to obesity interventions; however, the literature on this topic is limited. This dissertation examined sex differences in weight loss responses to lifestyle modification intervention, pharmacotherapy, and metabolic/bariatric surgery among the children and adolescent population. The following manuscripts are secondary data analyses.Manuscript 1 evaluated sex differences in response to lifestyle modification interventions. Two harmonized datasets (family-based intervention and nutrition-focused intervention) were used for the analyses. We found modest sex differences in the family-based intervention, and males lost more weight compared with females in the nutrition-focused intervention.Manuscript 2 assessed sex differences in response to obesity pharmacotherapy. Two high-quality randomized controlled trials (phentermine/topiramate and metformin) were utilized for the analyses. We found modest sex differences in response to either phentermine/topiramate or metformin. We further explored whether the pubertal stage modified the sex differences in response to each pharmacotherapy and observed that it modified the association in the metformin study.Manuscript 3 analyzed sex differences in response to metabolic and bariatric surgery. Four high-quality studies were harmonized into a single dataset. We found that males experienced greater weight loss compared to females.In summary, we found notable sex differences occur in some obesity interventions, but not in others. Understanding whether these sex differences are clinically meaningful in response to various obesity intervention types may guide obesity precision medicine.
■590 ▼aSchool code: 0130.
■650 4▼aPublic health
■650 4▼aEpidemiology
■650 4▼aPediatrics
■650 4▼aNutrition
■653 ▼aObesity intervention
■653 ▼aPediatric obesity
■653 ▼aChildhood obesity
■653 ▼aPharmacotherapy
■690 ▼a0573
■690 ▼a0767
■690 ▼a0766
■690 ▼a0570
■71020▼aUniversity of Minnesota▼bEpidemiology.
■7730 ▼tDissertations Abstracts International▼g87-03B.
■790 ▼a0130
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359449▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
