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Development of Technologies to Enable Clinical 7T Body MRI
Development of Technologies to Enable Clinical 7T Body MRI
Development of Technologies to Enable Clinical 7T Body MRI

Detailed Information

자료유형  
 학위논문 서양
최종처리일시  
20260202105258
ISBN  
9798263320188
DDC  
616
저자명  
Haluptzok, Tobey Daniel.
서명/저자  
Development of Technologies to Enable Clinical 7T Body MRI
발행사항  
[Sl] : University of Minnesota, 2025
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2025
형태사항  
143 p
주기사항  
Source: Dissertations Abstracts International, Volume: 87-05, Section: B.
주기사항  
Advisor: Metzger, Gregory J.
학위논문주기  
Thesis (Ph.D.)--University of Minnesota, 2025.
초록/해제  
요약Magnetic resonance imaging (MRI) has become an indispensable tool in both clinical and foundational research settings. As time has progressed the bounds of the main magnetic field have continued to be expanded, both lower and higher, with the current highest field strength used for body imaging sitting at 10.5 Tesla (T). However, FDA approval for clinical MRI is currently limited to 7T with only head and knee imaging being approved. This is because 7T body imaging has multiple challenges that must be addressed before clinical approval can be given. The first and foremost challenging aspect of 7T body imaging is electromagnetic (EM) field inhomogeneity. At 7T, the Larmor frequency of protons is around 297MHz which translates to an in-vivo wavelength of ≈ 11cm. Since the dimension of the human torso is multiple times larger than this, EM interference patterns are prevalent and require careful management. The first issue related to these interference patterns is spatially varying B1+ which results in variable excitation profiles; leading to images with variable contrast and signal dropout. The second challenge resulting from the short in-vivo wavelength is constructive E-field interference which can lead to high local specific absorption rate (SAR10g). The third challenge that comes with 7T imaging is the absence of remote transmit arrays. At lower fields, the transmit coils are placed behind the bore cover of the MRI machine and typically use a birdcage geometry. However, at 7T these birdcage coils have been found to be suboptimal. Instead, 7T MRI systems typically utilize local transceiver elements that both generate the transmit B1+ field to create the MR signal and measure the MR signal from the sample. In response to these challenges, this thesis aims to develop technologies that enable clinical 7T body imaging. One of the technologies developed for this thesis was a 32-channel shielded loop-dipole body array which was validated for in-vivo use in multiple anatomies. A second technology developed for this thesis is a new radio frequency (RF) shimming method which enables large field of view (FOV) turbo-spin echo (TSE) imaging with lower scan times. In addition, an analysis of local coil placement, which introduced new coil performance metrics, was conducted to inform the design of next generation body imaging arrays for 7T MRI. Lastly, a database consisting of whole-body, fat-water reconstructed human body models was acquired and processed into segmented models which lays the groundwork for subpopulation and patient specific SAR monitoring for applications at 7T and above.
일반주제명  
Medical imaging
일반주제명  
Biomedical engineering
일반주제명  
Electromagnetics
키워드  
Body imaging
키워드  
Magnetic resonance imaging
키워드  
Radio frequency coils
키워드  
Ultrahigh fields
기타저자  
University of Minnesota Biomedical Engineering
기본자료저록  
Dissertations Abstracts International. 87-05B.
전자적 위치 및 접속  
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MARC

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■1001  ▼aHaluptzok,  Tobey  Daniel.
■24510▼aDevelopment  of  Technologies  to  Enable  Clinical  7T  Body  MRI
■260    ▼a[Sl]▼bUniversity  of  Minnesota▼c2025
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2025
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■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  87-05,  Section:  B.
■500    ▼aAdvisor:  Metzger,  Gregory  J.
■5021  ▼aThesis  (Ph.D.)--University  of  Minnesota,  2025.
■520    ▼aMagnetic  resonance  imaging  (MRI)  has  become  an  indispensable  tool  in  both  clinical  and  foundational  research  settings.  As  time  has  progressed  the  bounds  of  the  main  magnetic  field  have  continued  to  be  expanded,  both  lower  and  higher,  with  the  current  highest  field  strength  used  for  body  imaging  sitting  at  10.5  Tesla  (T).  However,  FDA  approval  for  clinical  MRI  is  currently  limited  to  7T  with  only  head  and  knee  imaging  being  approved.  This  is  because  7T  body  imaging  has  multiple  challenges  that  must  be  addressed  before  clinical  approval  can  be  given.  The  first  and  foremost  challenging  aspect  of  7T  body  imaging  is  electromagnetic  (EM)  field  inhomogeneity.  At  7T,  the  Larmor  frequency  of  protons  is  around  297MHz  which  translates  to  an  in-vivo  wavelength  of  ≈  11cm.  Since  the  dimension  of  the  human  torso  is  multiple  times  larger  than  this,  EM  interference  patterns  are  prevalent  and  require  careful  management.  The  first  issue  related  to  these  interference  patterns  is  spatially  varying  B1+  which  results  in  variable  excitation  profiles;  leading  to  images  with  variable  contrast  and  signal  dropout.  The  second  challenge  resulting  from  the  short  in-vivo  wavelength  is  constructive  E-field  interference  which  can  lead  to  high  local  specific  absorption  rate  (SAR10g).  The  third  challenge  that  comes  with  7T  imaging  is  the  absence  of  remote  transmit  arrays.  At  lower  fields,  the  transmit  coils  are  placed  behind  the  bore  cover  of  the  MRI  machine  and  typically  use  a  birdcage  geometry.  However,  at  7T  these  birdcage  coils  have  been  found  to  be  suboptimal.  Instead,  7T  MRI  systems  typically  utilize  local  transceiver  elements  that  both  generate  the  transmit  B1+  field  to  create  the  MR  signal  and  measure  the  MR  signal  from  the  sample.  In  response  to  these  challenges,  this  thesis  aims  to  develop  technologies  that  enable  clinical  7T  body  imaging.  One  of  the  technologies  developed  for  this  thesis  was  a  32-channel  shielded  loop-dipole  body  array  which  was  validated  for  in-vivo  use  in  multiple  anatomies.  A  second  technology  developed  for  this  thesis  is  a  new  radio  frequency  (RF)  shimming  method  which  enables  large  field  of  view  (FOV)  turbo-spin  echo  (TSE)  imaging  with  lower  scan  times.  In  addition,  an  analysis  of  local  coil  placement,  which  introduced  new  coil  performance  metrics,  was  conducted  to  inform  the  design  of  next  generation  body  imaging  arrays  for  7T  MRI.  Lastly,  a  database  consisting  of  whole-body,  fat-water  reconstructed  human  body  models  was  acquired  and  processed  into  segmented  models  which  lays  the  groundwork  for  subpopulation  and  patient  specific  SAR  monitoring  for  applications  at  7T  and  above.
■590    ▼aSchool  code:  0130.
■650  4▼aMedical  imaging
■650  4▼aBiomedical  engineering
■650  4▼aElectromagnetics
■653    ▼aBody  imaging
■653    ▼aMagnetic  resonance  imaging
■653    ▼aRadio  frequency  coils
■653    ▼aUltrahigh  fields
■690    ▼a0574
■690    ▼a0541
■690    ▼a0607
■71020▼aUniversity  of  Minnesota▼bBiomedical  Engineering.
■7730  ▼tDissertations  Abstracts  International▼g87-05B.
■790    ▼a0130
■791    ▼aPh.D.
■792    ▼a2025
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17360059▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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