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Dendritic Mechanisms of Memory Encoding in the Hippocampus
Dendritic Mechanisms of Memory Encoding in the Hippocampus
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105300
- ISBN
- 9798263301354
- DDC
- 616
- 서명/저자
- Dendritic Mechanisms of Memory Encoding in the Hippocampus
- 발행사항
- [Sl] : Columbia University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 164 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-05, Section: B.
- 주기사항
- Advisor: Losonczy, Attila;Polleux, Franck.
- 학위논문주기
- Thesis (Ph.D.)--Columbia University, 2025.
- 초록/해제
- 요약The mammalian brain learns and forms memories continuously throughout an individual's lifetime, with an astonishing capacity to acquire, retain, and retrieve relevant new information while simultaneously filtering and forgetting behaviorally irrelevant experiences. Memories are thought to be encoded during 'online' periods of awake exploration and subsequently consolidated into stable memories during 'offline' periods of sleep; otherwise, memories are forgotten. Both the rapid encoding of spatial and episodic memories and their subsequent consolidation rely critically on the CA1 region of the hippocampus. Pyramidal neurons in CA1 rapidly form spatially selective firing fields called place fields, which serve as the cellular basis for memory encoding. The primary neural basis for these memory processes is thought to be synaptic plasticity, which underlies changes in the functional connectivity of neuronal circuits in the brain. Various forms of experience-dependent synaptic modifications, particularly at excitatory glutamatergic synapses, are widely considered to be the primary substrates of memory encoding and consolidation. However, causal links have yet to be made in vivo between synaptic plasticity and memory formation due to the difficulty of monitoring and manipulating plasticity at the single-neuron resolution in awake behaving animals. To address this, we combined high-resolution in vivo single-cell labeling (Chapter 1), 3D real-time motion correction (Chapter 2), and multicompartment two-photon dendritic glutamate, calcium, and voltage imaging to examine the subcellular plasticity mechanisms supporting hippocampal-dependent memory formation (Chapter 3).
- 일반주제명
- Neurosciences
- 일반주제명
- Electrical engineering
- 키워드
- Mammalian brain
- 기타저자
- Columbia University Neurobiology and Behavior
- 기본자료저록
- Dissertations Abstracts International. 87-05B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798263301354
■035 ▼a(MiAaPQ)AAI32280682
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aGonzalez, Kevin Christian.
■24510▼aDendritic Mechanisms of Memory Encoding in the Hippocampus
■260 ▼a[Sl]▼bColumbia University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a164 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-05, Section: B.
■500 ▼aAdvisor: Losonczy, Attila;Polleux, Franck.
■5021 ▼aThesis (Ph.D.)--Columbia University, 2025.
■520 ▼aThe mammalian brain learns and forms memories continuously throughout an individual's lifetime, with an astonishing capacity to acquire, retain, and retrieve relevant new information while simultaneously filtering and forgetting behaviorally irrelevant experiences. Memories are thought to be encoded during 'online' periods of awake exploration and subsequently consolidated into stable memories during 'offline' periods of sleep; otherwise, memories are forgotten. Both the rapid encoding of spatial and episodic memories and their subsequent consolidation rely critically on the CA1 region of the hippocampus. Pyramidal neurons in CA1 rapidly form spatially selective firing fields called place fields, which serve as the cellular basis for memory encoding. The primary neural basis for these memory processes is thought to be synaptic plasticity, which underlies changes in the functional connectivity of neuronal circuits in the brain. Various forms of experience-dependent synaptic modifications, particularly at excitatory glutamatergic synapses, are widely considered to be the primary substrates of memory encoding and consolidation. However, causal links have yet to be made in vivo between synaptic plasticity and memory formation due to the difficulty of monitoring and manipulating plasticity at the single-neuron resolution in awake behaving animals. To address this, we combined high-resolution in vivo single-cell labeling (Chapter 1), 3D real-time motion correction (Chapter 2), and multicompartment two-photon dendritic glutamate, calcium, and voltage imaging to examine the subcellular plasticity mechanisms supporting hippocampal-dependent memory formation (Chapter 3).
■590 ▼aSchool code: 0054.
■650 4▼aNeurosciences
■650 4▼aElectrical engineering
■653 ▼aMammalian brain
■653 ▼aEpisodic memories
■653 ▼aNeuronal circuits
■690 ▼a0317
■690 ▼a0544
■71020▼aColumbia University▼bNeurobiology and Behavior.
■7730 ▼tDissertations Abstracts International▼g87-05B.
■790 ▼a0054
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17360074▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
