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A Cellular Substrate for Multiregional Communication Across Large-Scale Networks in the Non-Human Primate
A Cellular Substrate for Multiregional Communication Across Large-Scale Networks in the Non-Human Primate
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202104724
- ISBN
- 9798293889358
- DDC
- 616
- 저자명
- Sedillo, Isaac.
- 서명/저자
- A Cellular Substrate for Multiregional Communication Across Large-Scale Networks in the Non-Human Primate
- 발행사항
- [Sl] : New York University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 288 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-03, Section: B.
- 주기사항
- Advisor: Pesaran, Bijan.
- 학위논문주기
- Thesis (Ph.D.)--New York University, 2025.
- 초록/해제
- 요약Neural decoding and neuromodulation technologies hold great promise for treating mood and other brain disorders in next-generation therapies that manipulate functional brain networks. Here, we perform a novel causal network analysis to decode multiregional communication in the primate mood processing network and determine how neuromodulation, short-burst tetanic microstimulation (sbTetMS), alters multiregional network communication. The causal network analysis revealed a mechanism of network excitability that regulates when a sender stimulation site communicates with receiver sites. Decoding network excitability from neural activity at modulator sites predicted sender-receiver communication while sbTetMS neuromodulation temporarily disrupted sender-receiver communication. Additionally, we characterize several activity-based electrophysiological biomarkers in frontal-cortical-striatal areas to understand their organizational properties during reinforcement learning in this model system. These results reveal specific network mechanisms of multiregional communication and suggest a new generation of brain therapies that combine neural decoding to predict multiregional communication with neuromodulation to disrupt multiregional communication and identify functional organization.
- 일반주제명
- Neurosciences
- 일반주제명
- Cellular biology
- 일반주제명
- Physiology
- 일반주제명
- Pharmacology
- 일반주제명
- Developmental biology
- 키워드
- Cortex
- 키워드
- Primates
- 키워드
- Striatum
- 키워드
- Neuromodulation
- 키워드
- Neural decoding
- 기타저자
- New York University Center for Neural Science
- 기본자료저록
- Dissertations Abstracts International. 87-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■006m o d
■007cr#unu||||||||
■020 ▼a9798293889358
■035 ▼a(MiAaPQ)AAI32121868
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aSedillo, Isaac.
■24512▼aA Cellular Substrate for Multiregional Communication Across Large-Scale Networks in the Non-Human Primate
■260 ▼a[Sl]▼bNew York University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a288 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-03, Section: B.
■500 ▼aAdvisor: Pesaran, Bijan.
■5021 ▼aThesis (Ph.D.)--New York University, 2025.
■520 ▼aNeural decoding and neuromodulation technologies hold great promise for treating mood and other brain disorders in next-generation therapies that manipulate functional brain networks. Here, we perform a novel causal network analysis to decode multiregional communication in the primate mood processing network and determine how neuromodulation, short-burst tetanic microstimulation (sbTetMS), alters multiregional network communication. The causal network analysis revealed a mechanism of network excitability that regulates when a sender stimulation site communicates with receiver sites. Decoding network excitability from neural activity at modulator sites predicted sender-receiver communication while sbTetMS neuromodulation temporarily disrupted sender-receiver communication. Additionally, we characterize several activity-based electrophysiological biomarkers in frontal-cortical-striatal areas to understand their organizational properties during reinforcement learning in this model system. These results reveal specific network mechanisms of multiregional communication and suggest a new generation of brain therapies that combine neural decoding to predict multiregional communication with neuromodulation to disrupt multiregional communication and identify functional organization.
■590 ▼aSchool code: 0146.
■650 4▼aNeurosciences
■650 4▼aCellular biology
■650 4▼aPhysiology
■650 4▼aPharmacology
■650 4▼aDevelopmental biology
■653 ▼aMultiregional communication
■653 ▼aCortex
■653 ▼aPrimates
■653 ▼aStriatum
■653 ▼aShort-burst tetanic microstimulation
■653 ▼aNeuromodulation
■653 ▼aNeural decoding
■690 ▼a0317
■690 ▼a0379
■690 ▼a0719
■690 ▼a0419
■690 ▼a0758
■71020▼aNew York University▼bCenter for Neural Science.
■7730 ▼tDissertations Abstracts International▼g87-03B.
■790 ▼a0146
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17358597▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
