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The Role of Interleukin-10 in Sex Differences in Pain and Long-Term Suppression of Pain
The Role of Interleukin-10 in Sex Differences in Pain and Long-Term Suppression of Pain
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105301
- ISBN
- 9798263301408
- DDC
- 616.079
- 저자명
- Sim, Jaewon.
- 서명/저자
- The Role of Interleukin-10 in Sex Differences in Pain and Long-Term Suppression of Pain
- 발행사항
- [Sl] : Michigan State University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 150 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-05, Section: B.
- 주기사항
- Advisor: Laumet, Geoffroy.
- 학위논문주기
- Thesis (Ph.D.)--Michigan State University, 2025.
- 초록/해제
- 요약Chronic pain is a prevalent disorder that compromises quality of life and imposes a burden on society. Increasing evidence indicates that the immune system can cause, worsen, prolong, or, conversely, resolve pain. In particular, interleukin (IL)-10 is a potent anti-inflammatory cytokine produced by immune cells including monocytes, macrophages, T cells, and B cells. Although IL-10 has been implicated in pain inhibition in both animals and humans, its pain-resolving mechanisms or cellular sources under pain conditions remain to be further elucidated. In my Ph.D. dissertation, I investigated the role of IL-10 in 1) sex differences in pain resolution in an inflammatory pain model and 2) long-term pain suppression in chemotherapy-induced neuropathic pain. 1) During skin inflammation, IL-10 in the inflamed skin resolves pain by signaling through IL-10R1+ sensory nerves innervating the skin. IL-10 is primarily produced by infiltrating monocytes, and IL-10+ monocytes serve as potent drivers of pain resolution. These cells are more abundant in males than females, which contributes to sex differences in pain resolution. The male predominance of IL-10+ monocytes is regulated by sex hormones, particularly androgen signaling, which promotes IL-10 production in monocytes. Altogether, androgen signaling enables the greater abundance of IL-10+ monocytes in males resulting in faster pain resolution compared with females. 2) In chemotherapy-induced neuropathic pain model, I found that pain is being actively suppressed by IL-10 during ostensible pain recovery. IL-10 is continuously produced from spinal meningeal resident macrophages. Especially, IL-10R signaling in DRG sensory neurons is crucial to maintain IL-10-driven pain suppression. I further identified that long-term pain suppression is driven by upregulation of δOR in DRG neurons, driven by IL-10. Collectively, my result shows that IL-10 upregulated δOR in DRG to maintain remission of pain. Overall, these dissertation studies advance our understanding of IL-10-mediated crosstalk between immune cells and pain-sensing neurons, providing new insights into promising therapeutic strategies for the treatment of chronic pain.
- 일반주제명
- Immunology
- 일반주제명
- Neurosciences
- 일반주제명
- Cellular biology
- 일반주제명
- Molecular biology
- 키워드
- Interleukin
- 키워드
- Monocytes
- 키워드
- Chronic pain
- 키워드
- Testosterone
- 기타저자
- Michigan State University Cell and Molecular Biology - Doctor of Philosophy
- 기본자료저록
- Dissertations Abstracts International. 87-05B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520260202105301
■006m o d
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■020 ▼a9798263301408
■035 ▼a(MiAaPQ)AAI32281562
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616.079
■1001 ▼aSim, Jaewon.▼0(orcid)0009-0007-4560-3525
■24510▼aThe Role of Interleukin-10 in Sex Differences in Pain and Long-Term Suppression of Pain
■260 ▼a[Sl]▼bMichigan State University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a150 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-05, Section: B.
■500 ▼aAdvisor: Laumet, Geoffroy.
■5021 ▼aThesis (Ph.D.)--Michigan State University, 2025.
■520 ▼aChronic pain is a prevalent disorder that compromises quality of life and imposes a burden on society. Increasing evidence indicates that the immune system can cause, worsen, prolong, or, conversely, resolve pain. In particular, interleukin (IL)-10 is a potent anti-inflammatory cytokine produced by immune cells including monocytes, macrophages, T cells, and B cells. Although IL-10 has been implicated in pain inhibition in both animals and humans, its pain-resolving mechanisms or cellular sources under pain conditions remain to be further elucidated. In my Ph.D. dissertation, I investigated the role of IL-10 in 1) sex differences in pain resolution in an inflammatory pain model and 2) long-term pain suppression in chemotherapy-induced neuropathic pain. 1) During skin inflammation, IL-10 in the inflamed skin resolves pain by signaling through IL-10R1+ sensory nerves innervating the skin. IL-10 is primarily produced by infiltrating monocytes, and IL-10+ monocytes serve as potent drivers of pain resolution. These cells are more abundant in males than females, which contributes to sex differences in pain resolution. The male predominance of IL-10+ monocytes is regulated by sex hormones, particularly androgen signaling, which promotes IL-10 production in monocytes. Altogether, androgen signaling enables the greater abundance of IL-10+ monocytes in males resulting in faster pain resolution compared with females. 2) In chemotherapy-induced neuropathic pain model, I found that pain is being actively suppressed by IL-10 during ostensible pain recovery. IL-10 is continuously produced from spinal meningeal resident macrophages. Especially, IL-10R signaling in DRG sensory neurons is crucial to maintain IL-10-driven pain suppression. I further identified that long-term pain suppression is driven by upregulation of δOR in DRG neurons, driven by IL-10. Collectively, my result shows that IL-10 upregulated δOR in DRG to maintain remission of pain. Overall, these dissertation studies advance our understanding of IL-10-mediated crosstalk between immune cells and pain-sensing neurons, providing new insights into promising therapeutic strategies for the treatment of chronic pain.
■590 ▼aSchool code: 0128.
■650 4▼aImmunology
■650 4▼aNeurosciences
■650 4▼aCellular biology
■650 4▼aMolecular biology
■653 ▼aInterleukin
■653 ▼aMonocytes
■653 ▼aChronic pain
■653 ▼aTestosterone
■690 ▼a0982
■690 ▼a0317
■690 ▼a0379
■690 ▼a0307
■71020▼aMichigan State University▼bCell and Molecular Biology - Doctor of Philosophy.
■7730 ▼tDissertations Abstracts International▼g87-05B.
■790 ▼a0128
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17360083▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
