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Active Transport in Complex Media: Bacterial Transport, Mucus Mechanics, and Drug Delivery
Active Transport in Complex Media: Bacterial Transport, Mucus Mechanics, and Drug Delivery
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105303
- ISBN
- 9798273301771
- DDC
- 574.191
- 저자명
- Prabhune, A. G.
- 서명/저자
- Active Transport in Complex Media: Bacterial Transport, Mucus Mechanics, and Drug Delivery
- 발행사항
- [Sl] : University of Colorado at Boulder, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 113 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-07, Section: B.
- 주기사항
- Advisor: Figueroa-Morales, Nuris.
- 학위논문주기
- Thesis (Ph.D.)--University of Colorado at Boulder, 2025.
- 초록/해제
- 요약In this dissertation, we investigate how fluid complexity and geometric confinement shape active transport, using two model systems: nematic liquid crystals and mucus. First, we examine bacterial locomotion in biocompatible liquid crystals. We identify two mechanisms by which Bacillus subtilis reverses its swimming direction (flagellar buckling and alternating bundle rotation) revealing how anisotropy constrains bacterial motility. We then characterize the rheology of natural cow lung mucus, quantifying shear-induced alignment of mucin fibers and measuring viscoelastic parameters using stress relaxation and creep tests. These results provide insight into how mucus microstructure reorganizes under physiologically relevant stresses. Building on this framework, we use bacteriophage-based nanoparticles ("nanophages") decorated with hyaluronic acid to enhance drug delivery through mucus. We show that these particles maintain mobility while remaining bound to mucus and that therapeutic nanophages retain biological activity. Finally, we investigate bacterial accumulation in microchannels, demonstrating that geometric confinement drives preferential localization and developing a simple model to explain this behavior. Together, these studies highlight how physical properties of complex environments regulate bacterial transport and inform the design of therapeutic delivery strategies across mucosal barriers.
- 일반주제명
- Biophysics
- 일반주제명
- Pharmaceutical sciences
- 일반주제명
- Biochemistry
- 키워드
- Fluid complexity
- 키워드
- Drug delivery
- 키워드
- Microchannels
- 키워드
- Mucus
- 기타저자
- University of Colorado at Boulder Physics
- 기본자료저록
- Dissertations Abstracts International. 87-07B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798273301771
■035 ▼a(MiAaPQ)AAI32282192
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574.191
■1001 ▼aPrabhune, A. G.
■24510▼aActive Transport in Complex Media: Bacterial Transport, Mucus Mechanics, and Drug Delivery
■260 ▼a[Sl]▼bUniversity of Colorado at Boulder▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a113 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-07, Section: B.
■500 ▼aAdvisor: Figueroa-Morales, Nuris.
■5021 ▼aThesis (Ph.D.)--University of Colorado at Boulder, 2025.
■520 ▼aIn this dissertation, we investigate how fluid complexity and geometric confinement shape active transport, using two model systems: nematic liquid crystals and mucus. First, we examine bacterial locomotion in biocompatible liquid crystals. We identify two mechanisms by which Bacillus subtilis reverses its swimming direction (flagellar buckling and alternating bundle rotation) revealing how anisotropy constrains bacterial motility. We then characterize the rheology of natural cow lung mucus, quantifying shear-induced alignment of mucin fibers and measuring viscoelastic parameters using stress relaxation and creep tests. These results provide insight into how mucus microstructure reorganizes under physiologically relevant stresses. Building on this framework, we use bacteriophage-based nanoparticles ("nanophages") decorated with hyaluronic acid to enhance drug delivery through mucus. We show that these particles maintain mobility while remaining bound to mucus and that therapeutic nanophages retain biological activity. Finally, we investigate bacterial accumulation in microchannels, demonstrating that geometric confinement drives preferential localization and developing a simple model to explain this behavior. Together, these studies highlight how physical properties of complex environments regulate bacterial transport and inform the design of therapeutic delivery strategies across mucosal barriers.
■590 ▼aSchool code: 0051.
■650 4▼aBiophysics
■650 4▼aPharmaceutical sciences
■650 4▼aBiochemistry
■653 ▼aBacterial locomotion
■653 ▼aFluid complexity
■653 ▼aDrug delivery
■653 ▼aMicrochannels
■653 ▼aMucus
■690 ▼a0786
■690 ▼a0487
■690 ▼a0572
■71020▼aUniversity of Colorado at Boulder▼bPhysics.
■7730 ▼tDissertations Abstracts International▼g87-07B.
■790 ▼a0051
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17360096▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
