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Elucidating Cell Intrinsic Regulators of CD8 T Cell Differentiation: KLF2 Maintains Effector CD8 Lineage Fidelity
Elucidating Cell Intrinsic Regulators of CD8 T Cell Differentiation: KLF2 Maintains Effector CD8 Lineage Fidelity
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202103029
- ISBN
- 9798286432622
- DDC
- 616.079
- 저자명
- Fagerberg, Eric.
- 서명/저자
- Elucidating Cell Intrinsic Regulators of CD8 T Cell Differentiation: KLF2 Maintains Effector CD8 Lineage Fidelity
- 발행사항
- [Sl] : Yale University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 155 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
- 주기사항
- Advisor: Joshi, Nikhil.
- 학위논문주기
- Thesis (Ph.D.)--Yale University, 2025.
- 초록/해제
- 요약CD8 T cells are an integral part of the immune system, principally responsible for the cytolytic clearance of virally infected and cancerous cells. They adapt to the nature of the immune response they are partaking in by adopting distinct cell fates through a process of highly coordinated differentiation. These fates are characterized by the activation and suppression of functional programs under the control of transcription factors and epigenetic machinery, which integrate cell extrinsic signals to drive differentiation. Here we elucidate the function of a group of transcription factors in dictating CD8 T cell differentiation in infection. We go on to characterize one specific factor of interest, KLF2, which we find has the unique role of maintaining lineage fidelity along the differentiation trajectory of effector and memory CD8 T cells. We find KLF2 not only regulates T cell trafficking as has been previously described but also contributes to cell fate decisions through the suppression of the exhaustion promoting factor TOX and enablement of effector defining factors such as TBET. Finally, we characterize a critical role for KLF2 in maintaining stem-like CD8 T cells in the context of tumors and tumor draining lymph nodes, thereby supporting the anti-tumor immune response and potentiating memory and effector function.
- 일반주제명
- Immunology
- 일반주제명
- Cellular biology
- 일반주제명
- Oncology
- 키워드
- Cancer
- 키워드
- Immunotherapy
- 키워드
- T cells
- 기타저자
- Yale University Immunobiology
- 기본자료저록
- Dissertations Abstracts International. 86-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798286432622
■035 ▼a(MiAaPQ)AAI31845696
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616.079
■1001 ▼aFagerberg, Eric.
■24510▼aElucidating Cell Intrinsic Regulators of CD8 T Cell Differentiation: KLF2 Maintains Effector CD8 Lineage Fidelity
■260 ▼a[Sl]▼bYale University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a155 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-12, Section: B.
■500 ▼aAdvisor: Joshi, Nikhil.
■5021 ▼aThesis (Ph.D.)--Yale University, 2025.
■520 ▼aCD8 T cells are an integral part of the immune system, principally responsible for the cytolytic clearance of virally infected and cancerous cells. They adapt to the nature of the immune response they are partaking in by adopting distinct cell fates through a process of highly coordinated differentiation. These fates are characterized by the activation and suppression of functional programs under the control of transcription factors and epigenetic machinery, which integrate cell extrinsic signals to drive differentiation. Here we elucidate the function of a group of transcription factors in dictating CD8 T cell differentiation in infection. We go on to characterize one specific factor of interest, KLF2, which we find has the unique role of maintaining lineage fidelity along the differentiation trajectory of effector and memory CD8 T cells. We find KLF2 not only regulates T cell trafficking as has been previously described but also contributes to cell fate decisions through the suppression of the exhaustion promoting factor TOX and enablement of effector defining factors such as TBET. Finally, we characterize a critical role for KLF2 in maintaining stem-like CD8 T cells in the context of tumors and tumor draining lymph nodes, thereby supporting the anti-tumor immune response and potentiating memory and effector function.
■590 ▼aSchool code: 0265.
■650 4▼aImmunology
■650 4▼aCellular biology
■650 4▼aOncology
■653 ▼aCancer
■653 ▼aImmunotherapy
■653 ▼aT cells
■653 ▼aEffector function
■690 ▼a0982
■690 ▼a0379
■690 ▼a0992
■71020▼aYale University▼bImmunobiology.
■7730 ▼tDissertations Abstracts International▼g86-12B.
■790 ▼a0265
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17356755▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
