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Assessing Survival Outcomes Among Pediatric In-Hospital Cardiac Arrests Surrounding Updates to the Pediatric Advanced Life Support Guidelines
Assessing Survival Outcomes Among Pediatric In-Hospital Cardiac Arrests Surrounding Updates to the Pediatric Advanced Life Support Guidelines
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202103131
- ISBN
- 9798293840441
- DDC
- 610.73
- 서명/저자
- Assessing Survival Outcomes Among Pediatric In-Hospital Cardiac Arrests Surrounding Updates to the Pediatric Advanced Life Support Guidelines
- 발행사항
- [Sl] : The University of Utah, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 192 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-03, Section: B.
- 주기사항
- Advisor: Sward, Katherine A.
- 학위논문주기
- Thesis (Ph.D.)--The University of Utah, 2025.
- 초록/해제
- 요약The Pediatric Advanced Life Support (PALS) guidelines, developed by the American Heart Association (AHA), have undergone multiple updates to improve resuscitation outcomes in children. Despite these updates, less than half of children who experience an in-hospital arrest survive to hospital discharge. There is limited evidence linking the guidelines to improved survival outcomes. This study sought to (a) characterize the PALS guidelines and describe significant changes to the recommendations over time, (b) determine the extent to which the GWTG-R registry data represent the scope of the PALS guidelines, and (c) evaluate the association between major PALS updates and survival outcomes in pediatric in-hospital cardiopulmonary arrest between January 2000 and December 2023.A total of 17,366 patients with cardiopulmonary arrests were included in the study. Survival to discharge improved from 29.4% (95% CI: 23.3% - 36.2%) in 2000, to a peak in 2016 of 54.9% (95% CI: 51.1% - 58.7%), then declined to 47.6% in 2023 (95% CI: 44.3% - 50.8%). Sustained ROSC showed a similar trend, peaking at 82.2% (2015-2020) before declining. Younger age and daytime weekday events were associated with better outcomes. An initial nonshockable rhythm (asystole, PEA) leads to poorer outcomes (p 0.001). Bradycardia with a pulse did not have a significant effect on outcomes (p = 0.09). Those with a COVID diagnosis had higher log odds of survival than those without a COVID diagnosis (p 0.001). There was a 7.5-second improvement in time to starting chest compressions from 2000 to 2023 (p 0.001), a 33-second improvement in time to the first epinephrine dose, an 8-second improvement in time to defibrillation, though with a great deal of variability (p = 0.96), and time to an advanced airway lengthened by 1.23 minutes (p = 0.15) since 2010. While survival outcomes generally improved over the study period, there is evidence of a plateau since 2010 across all outcomes, making it challenging to attribute gains to PALS updates. Factors such as initial rhythm, age, and the timing of arrests remain strong outcome predictors.
- 일반주제명
- Nursing
- 일반주제명
- Bioinformatics
- 일반주제명
- Medicine
- 일반주제명
- Pediatrics
- 일반주제명
- Clinical psychology
- 키워드
- Resuscitation
- 키워드
- COVID diagnosis
- 기타저자
- The University of Utah Nursing
- 기본자료저록
- Dissertations Abstracts International. 87-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798293840441
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■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a610.73
■1001 ▼aHarvey, Jennifer.
■24510▼aAssessing Survival Outcomes Among Pediatric In-Hospital Cardiac Arrests Surrounding Updates to the Pediatric Advanced Life Support Guidelines
■260 ▼a[Sl]▼bThe University of Utah▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a192 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-03, Section: B.
■500 ▼aAdvisor: Sward, Katherine A.
■5021 ▼aThesis (Ph.D.)--The University of Utah, 2025.
■520 ▼aThe Pediatric Advanced Life Support (PALS) guidelines, developed by the American Heart Association (AHA), have undergone multiple updates to improve resuscitation outcomes in children. Despite these updates, less than half of children who experience an in-hospital arrest survive to hospital discharge. There is limited evidence linking the guidelines to improved survival outcomes. This study sought to (a) characterize the PALS guidelines and describe significant changes to the recommendations over time, (b) determine the extent to which the GWTG-R registry data represent the scope of the PALS guidelines, and (c) evaluate the association between major PALS updates and survival outcomes in pediatric in-hospital cardiopulmonary arrest between January 2000 and December 2023.A total of 17,366 patients with cardiopulmonary arrests were included in the study. Survival to discharge improved from 29.4% (95% CI: 23.3% - 36.2%) in 2000, to a peak in 2016 of 54.9% (95% CI: 51.1% - 58.7%), then declined to 47.6% in 2023 (95% CI: 44.3% - 50.8%). Sustained ROSC showed a similar trend, peaking at 82.2% (2015-2020) before declining. Younger age and daytime weekday events were associated with better outcomes. An initial nonshockable rhythm (asystole, PEA) leads to poorer outcomes (p 0.001). Bradycardia with a pulse did not have a significant effect on outcomes (p = 0.09). Those with a COVID diagnosis had higher log odds of survival than those without a COVID diagnosis (p 0.001). There was a 7.5-second improvement in time to starting chest compressions from 2000 to 2023 (p 0.001), a 33-second improvement in time to the first epinephrine dose, an 8-second improvement in time to defibrillation, though with a great deal of variability (p = 0.96), and time to an advanced airway lengthened by 1.23 minutes (p = 0.15) since 2010. While survival outcomes generally improved over the study period, there is evidence of a plateau since 2010 across all outcomes, making it challenging to attribute gains to PALS updates. Factors such as initial rhythm, age, and the timing of arrests remain strong outcome predictors.
■590 ▼aSchool code: 0240.
■650 4▼aNursing
■650 4▼aBioinformatics
■650 4▼aMedicine
■650 4▼aPediatrics
■650 4▼aClinical psychology
■653 ▼aPediatric Advanced Life Support
■653 ▼aAmerican Heart Association
■653 ▼aResuscitation
■653 ▼aSurvival outcomes
■653 ▼aCOVID diagnosis
■690 ▼a0569
■690 ▼a0715
■690 ▼a0564
■690 ▼a0767
■690 ▼a0622
■71020▼aThe University of Utah▼bNursing.
■7730 ▼tDissertations Abstracts International▼g87-03B.
■790 ▼a0240
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17357103▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.


