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Assessing Survival Outcomes Among Pediatric In-Hospital Cardiac Arrests Surrounding Updates to the Pediatric Advanced Life Support Guidelines
Assessing Survival Outcomes Among Pediatric In-Hospital Cardiac Arrests Surrounding Update...
Assessing Survival Outcomes Among Pediatric In-Hospital Cardiac Arrests Surrounding Updates to the Pediatric Advanced Life Support Guidelines

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자료유형  
 학위논문 서양
최종처리일시  
20260202103131
ISBN  
9798293840441
DDC  
610.73
저자명  
Harvey, Jennifer.
서명/저자  
Assessing Survival Outcomes Among Pediatric In-Hospital Cardiac Arrests Surrounding Updates to the Pediatric Advanced Life Support Guidelines
발행사항  
[Sl] : The University of Utah, 2025
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2025
형태사항  
192 p
주기사항  
Source: Dissertations Abstracts International, Volume: 87-03, Section: B.
주기사항  
Advisor: Sward, Katherine A.
학위논문주기  
Thesis (Ph.D.)--The University of Utah, 2025.
초록/해제  
요약The Pediatric Advanced Life Support (PALS) guidelines, developed by the American Heart Association (AHA), have undergone multiple updates to improve resuscitation outcomes in children. Despite these updates, less than half of children who experience an in-hospital arrest survive to hospital discharge. There is limited evidence linking the guidelines to improved survival outcomes. This study sought to (a) characterize the PALS guidelines and describe significant changes to the recommendations over time, (b) determine the extent to which the GWTG-R registry data represent the scope of the PALS guidelines, and (c) evaluate the association between major PALS updates and survival outcomes in pediatric in-hospital cardiopulmonary arrest between January 2000 and December 2023.A total of 17,366 patients with cardiopulmonary arrests were included in the study. Survival to discharge improved from 29.4% (95% CI: 23.3% - 36.2%) in 2000, to a peak in 2016 of 54.9% (95% CI: 51.1% - 58.7%), then declined to 47.6% in 2023 (95% CI: 44.3% - 50.8%). Sustained ROSC showed a similar trend, peaking at 82.2% (2015-2020) before declining. Younger age and daytime weekday events were associated with better outcomes. An initial nonshockable rhythm (asystole, PEA) leads to poorer outcomes (p 0.001). Bradycardia with a pulse did not have a significant effect on outcomes (p = 0.09). Those with a COVID diagnosis had higher log odds of survival than those without a COVID diagnosis (p 0.001). There was a 7.5-second improvement in time to starting chest compressions from 2000 to 2023 (p 0.001), a 33-second improvement in time to the first epinephrine dose, an 8-second improvement in time to defibrillation, though with a great deal of variability (p = 0.96), and time to an advanced airway lengthened by 1.23 minutes (p = 0.15) since 2010.  While survival outcomes generally improved over the study period, there is evidence of a plateau since 2010 across all outcomes, making it challenging to attribute gains to PALS updates. Factors such as initial rhythm, age, and the timing of arrests remain strong outcome predictors.
일반주제명  
Nursing
일반주제명  
Bioinformatics
일반주제명  
Medicine
일반주제명  
Pediatrics
일반주제명  
Clinical psychology
키워드  
Pediatric Advanced Life Support
키워드  
American Heart Association
키워드  
Resuscitation
키워드  
Survival outcomes
키워드  
COVID diagnosis
기타저자  
The University of Utah Nursing
기본자료저록  
Dissertations Abstracts International. 87-03B.
전자적 위치 및 접속  
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MARC

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■24510▼aAssessing  Survival  Outcomes  Among  Pediatric  In-Hospital  Cardiac  Arrests  Surrounding  Updates  to  the  Pediatric  Advanced  Life  Support  Guidelines
■260    ▼a[Sl]▼bThe  University  of  Utah▼c2025
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2025
■300    ▼a192  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  87-03,  Section:  B.
■500    ▼aAdvisor:  Sward,  Katherine  A.
■5021  ▼aThesis  (Ph.D.)--The  University  of  Utah,  2025.
■520    ▼aThe  Pediatric  Advanced  Life  Support  (PALS)  guidelines,  developed  by  the  American  Heart  Association  (AHA),  have  undergone  multiple  updates  to  improve  resuscitation  outcomes  in  children.  Despite  these  updates,  less  than  half  of  children  who  experience  an  in-hospital  arrest  survive  to  hospital  discharge.  There  is  limited  evidence  linking  the  guidelines  to  improved  survival  outcomes.  This  study  sought  to  (a)  characterize  the  PALS  guidelines  and  describe  significant  changes  to  the  recommendations  over  time,  (b)  determine  the  extent  to  which  the  GWTG-R  registry  data  represent  the  scope  of  the  PALS  guidelines,  and  (c)  evaluate  the  association  between  major  PALS  updates  and  survival  outcomes  in  pediatric  in-hospital  cardiopulmonary  arrest  between  January  2000  and  December  2023.A  total  of  17,366  patients  with  cardiopulmonary  arrests  were  included  in  the  study.  Survival  to  discharge  improved  from  29.4%  (95%  CI:  23.3%  -  36.2%)  in  2000,  to  a  peak  in  2016  of  54.9%  (95%  CI:  51.1%  -  58.7%),  then  declined  to  47.6%  in  2023  (95%  CI:  44.3%  -  50.8%).  Sustained  ROSC  showed  a  similar  trend,  peaking  at  82.2%  (2015-2020)  before  declining.  Younger  age  and  daytime  weekday  events  were  associated  with  better  outcomes.  An  initial  nonshockable  rhythm  (asystole,  PEA)  leads  to  poorer  outcomes  (p    0.001).  Bradycardia  with  a  pulse  did  not  have  a  significant  effect  on  outcomes  (p  =  0.09).  Those  with  a  COVID  diagnosis  had  higher  log  odds  of  survival  than  those  without  a  COVID  diagnosis  (p    0.001).  There  was  a  7.5-second  improvement  in time  to  starting  chest  compressions  from  2000  to  2023  (p    0.001),  a  33-second  improvement  in  time  to  the  first  epinephrine  dose,  an  8-second  improvement  in  time  to  defibrillation,  though  with  a  great  deal  of  variability  (p  =  0.96),  and  time  to  an  advanced  airway  lengthened  by  1.23  minutes  (p  =  0.15)  since  2010.  While  survival  outcomes  generally  improved  over  the  study  period,  there  is  evidence  of  a  plateau  since  2010  across  all  outcomes,  making  it  challenging  to  attribute  gains  to  PALS  updates.  Factors  such  as  initial  rhythm,  age,  and  the  timing  of  arrests  remain  strong  outcome  predictors.
■590    ▼aSchool  code:  0240.
■650  4▼aNursing
■650  4▼aBioinformatics
■650  4▼aMedicine
■650  4▼aPediatrics
■650  4▼aClinical  psychology
■653    ▼aPediatric  Advanced  Life  Support
■653    ▼aAmerican  Heart  Association
■653    ▼aResuscitation
■653    ▼aSurvival  outcomes
■653    ▼aCOVID  diagnosis
■690    ▼a0569
■690    ▼a0715
■690    ▼a0564
■690    ▼a0767
■690    ▼a0622
■71020▼aThe  University  of  Utah▼bNursing.
■7730  ▼tDissertations  Abstracts  International▼g87-03B.
■790    ▼a0240
■791    ▼aPh.D.
■792    ▼a2025
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17357103▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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