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Investigating the Roles of F-BAR Proteins CIP4 and FBP17 in Cortical Development and Neuronal Migration
Investigating the Roles of F-BAR Proteins CIP4 and FBP17 in Cortical Development and Neuronal Migration
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202104727
- ISBN
- 9798291552414
- DDC
- 616
- 서명/저자
- Investigating the Roles of F-BAR Proteins CIP4 and FBP17 in Cortical Development and Neuronal Migration
- 발행사항
- [Sl] : The University of Wisconsin - Madison, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 128 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-02, Section: B.
- 주기사항
- Advisor: Dent, Erik W.
- 학위논문주기
- Thesis (Ph.D.)--The University of Wisconsin - Madison, 2025.
- 초록/해제
- 요약Neuronal migration is a critical process in the development of the embryonic cerebral cortex, ensuring that neurons reach their proper locations to form functional circuits. Excitatory neurons migrate radially from the ventricular zone to the cortical plate through several migratory zones, changing their morphology as they progress. Migrating neurons start out in a bipolar morphology, switch to a multipolar morphology, and then must switch back to a bipolar morphology. These transitions require tightly regulated cytoskeletal remodeling and plasma membrane dynamics. Failure to coordinate these processes can result in severe cortical malformations, such as lissencephaly and periventricular heterotopia. Rho GTPases and actin-associated proteins have been implicated in regulating the morphological changes required for migration, however, the molecular coordination between membrane and cytoskeletal dynamics remains poorly understood. Members of the F-BAR protein family are emerging as key candidates in this coordination, due to their unique ability to sense and induce membrane curvature and interact with actin regulatory proteins. This dissertation investigates the roles of two F-BAR proteins, CIP4 and FBP17, in radial neuronal migration. We show that both CIP4 and FBP17 drive migration by coordinating neurite dynamics in radial migrating neurons. These results suggest that CIP4 and FBP17 function in distinct yet complementary ways to regulate the morphological transitions necessary for successful migration. Furthermore, this work supports a broader model in which F-BAR proteins act as integrators of membrane shape and cytoskeletal architecture during neuronal development. Together, these findings expand our understanding of the molecular control of neuronal migration and position F-BAR proteins as critical mediators of membrane-cytoskeletal coordination in the developing brain.
- 일반주제명
- Neurosciences
- 일반주제명
- Cellular biology
- 일반주제명
- Molecular biology
- 키워드
- Neurodevelopment
- 기타저자
- The University of Wisconsin - Madison Neuroscience
- 기본자료저록
- Dissertations Abstracts International. 87-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798291552414
■035 ▼a(MiAaPQ)AAI32122567
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aEnglish, Lauren A.
■24510▼aInvestigating the Roles of F-BAR Proteins CIP4 and FBP17 in Cortical Development and Neuronal Migration
■260 ▼a[Sl]▼bThe University of Wisconsin - Madison▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a128 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-02, Section: B.
■500 ▼aAdvisor: Dent, Erik W.
■5021 ▼aThesis (Ph.D.)--The University of Wisconsin - Madison, 2025.
■520 ▼aNeuronal migration is a critical process in the development of the embryonic cerebral cortex, ensuring that neurons reach their proper locations to form functional circuits. Excitatory neurons migrate radially from the ventricular zone to the cortical plate through several migratory zones, changing their morphology as they progress. Migrating neurons start out in a bipolar morphology, switch to a multipolar morphology, and then must switch back to a bipolar morphology. These transitions require tightly regulated cytoskeletal remodeling and plasma membrane dynamics. Failure to coordinate these processes can result in severe cortical malformations, such as lissencephaly and periventricular heterotopia. Rho GTPases and actin-associated proteins have been implicated in regulating the morphological changes required for migration, however, the molecular coordination between membrane and cytoskeletal dynamics remains poorly understood. Members of the F-BAR protein family are emerging as key candidates in this coordination, due to their unique ability to sense and induce membrane curvature and interact with actin regulatory proteins. This dissertation investigates the roles of two F-BAR proteins, CIP4 and FBP17, in radial neuronal migration. We show that both CIP4 and FBP17 drive migration by coordinating neurite dynamics in radial migrating neurons. These results suggest that CIP4 and FBP17 function in distinct yet complementary ways to regulate the morphological transitions necessary for successful migration. Furthermore, this work supports a broader model in which F-BAR proteins act as integrators of membrane shape and cytoskeletal architecture during neuronal development. Together, these findings expand our understanding of the molecular control of neuronal migration and position F-BAR proteins as critical mediators of membrane-cytoskeletal coordination in the developing brain.
■590 ▼aSchool code: 0262.
■650 4▼aNeurosciences
■650 4▼aCellular biology
■650 4▼aMolecular biology
■653 ▼aCortical development
■653 ▼aNeurodevelopment
■653 ▼aNeuronal migration
■653 ▼aEmbryonic cerebral cortex
■690 ▼a0317
■690 ▼a0379
■690 ▼a0307
■71020▼aThe University of Wisconsin - Madison▼bNeuroscience.
■7730 ▼tDissertations Abstracts International▼g87-02B.
■790 ▼a0262
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17358621▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
