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Health-Related Social Needs and Cancer Burden in Persons Living With Human Immunodeficiency Virus
Health-Related Social Needs and Cancer Burden in Persons Living With Human Immunodeficienc...
Health-Related Social Needs and Cancer Burden in Persons Living With Human Immunodeficiency Virus

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자료유형  
 학위논문 서양
최종처리일시  
20260202104729
ISBN  
9798315778394
DDC  
614.4
저자명  
Zhou, Guangjin.
서명/저자  
Health-Related Social Needs and Cancer Burden in Persons Living With Human Immunodeficiency Virus
발행사항  
[Sl] : Case Western Reserve University, 2024
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2024
형태사항  
165 p
주기사항  
Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
주기사항  
Advisor: Koroukian, Siran M.;Spilsbury, James.
학위논문주기  
Thesis (Ph.D.)--Case Western Reserve University, 2024.
초록/해제  
요약Objective: To assess the impact of health-related social needs (HRSN) on hospital readmission and cancer prevalence in persons living with HIV (PLWH). Study population and methods: For the HRSN work, I utilized four-year (2016-2019) longitudinal State Inpatient Databases (SID) from Florida and Maryland. The study encompassed 43,229 HIV patients in Florida and 12,396 in Maryland. For the cancer burden work, I used one-year nationwide Medicaid enrollment files. Cancer burden in men and women living with HIV were examined separately. The sample of men included 82,495 with HIV and 7,302,523 without HIV, and that of women included 72,508 with HIV and 17,353,963 without HIV. The traditional statistical and data mining approaches were used to analyze data. Results: Key findings include: (1) A significantly high prevalence of social needs was associated with increased PLWH hospital readmission, and these needs emerged as critical elements in predicting hospital readmission. (2) The spectrum of cancer burden differed by gender, but anal cancer and non-Hodgkin's lymphoma (NHL) were consistently among the most prevalent cancer types in both men and women. (3) Among men living with HIV, the prevalence of non-AIDS defining cancers was about twice that of men without HIV, with anal cancer and non-Hodgkin's lymphoma having the highest prevalence. (4) Among women living with HIV, cervical cancer, Kaposi's sarcoma, anal cancer, and Hodgkin's and non-Hodgkin's lymphoma remained highly prevalent. (5) Age had a more robust modification effect in younger HIV patients compared to the non-HIV population of same age range. Implications: This study both identified the pivotal role of health-related social needs in hospital readmission and elucidated cancer disparities in PLWH. It is imperative for healthcare providers and policymakers to acknowledge social factors as critical in reducing hospital readmissions for HIV patients. Recognizing cancer disparities is essential for developing targeted interventions and improving healthcare outcomes for both men and women living with HIV. Initiating HPV vaccination for anal and cervical cancer should target adolescents and young adults among HIV patients. Additionally, cancer prevention and screening should prioritize high-risk minority PLWH from an early age.
일반주제명  
Epidemiology
일반주제명  
Health sciences
일반주제명  
Immunology
키워드  
Health-related social needs
키워드  
State Inpatient Databases
키워드  
Human Immunodeficiency Virus
기타저자  
Case Western Reserve University Clinical Research
기본자료저록  
Dissertations Abstracts International. 86-12B.
전자적 위치 및 접속  
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MARC

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■1001  ▼aZhou,  Guangjin.
■24510▼aHealth-Related  Social  Needs  and  Cancer  Burden  in  Persons  Living  With  Human  Immunodeficiency  Virus
■260    ▼a[Sl]▼bCase  Western  Reserve  University▼c2024
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2024
■300    ▼a165  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  86-12,  Section:  B.
■500    ▼aAdvisor:  Koroukian,  Siran  M.;Spilsbury,  James.
■5021  ▼aThesis  (Ph.D.)--Case  Western  Reserve  University,  2024.
■520    ▼aObjective:  To  assess  the  impact  of  health-related  social  needs  (HRSN)  on  hospital  readmission  and  cancer  prevalence  in  persons  living  with  HIV  (PLWH).  Study  population  and  methods:  For  the  HRSN  work,  I  utilized  four-year  (2016-2019)  longitudinal  State  Inpatient  Databases  (SID)  from  Florida  and  Maryland.  The  study  encompassed  43,229  HIV  patients  in  Florida  and  12,396  in  Maryland.  For  the  cancer  burden  work,  I  used  one-year  nationwide  Medicaid  enrollment  files.  Cancer  burden  in  men  and  women  living  with  HIV  were  examined  separately.  The  sample  of  men  included  82,495  with  HIV  and  7,302,523  without  HIV,  and  that  of  women  included  72,508  with  HIV  and  17,353,963  without  HIV.  The  traditional  statistical  and  data  mining  approaches  were  used  to  analyze  data.  Results:  Key  findings  include:  (1)  A  significantly  high  prevalence  of  social  needs  was  associated  with  increased  PLWH  hospital  readmission,  and  these  needs  emerged  as  critical  elements  in  predicting  hospital  readmission.  (2)  The  spectrum  of  cancer  burden  differed  by  gender,  but  anal  cancer  and  non-Hodgkin's  lymphoma  (NHL)  were  consistently  among  the  most  prevalent  cancer  types  in  both  men  and  women.  (3)  Among  men  living  with  HIV,  the  prevalence  of  non-AIDS  defining  cancers  was  about  twice  that  of  men  without  HIV,  with  anal  cancer  and  non-Hodgkin's  lymphoma  having  the  highest  prevalence.  (4)  Among  women  living  with  HIV,  cervical  cancer,  Kaposi's  sarcoma,  anal  cancer,  and  Hodgkin's  and  non-Hodgkin's  lymphoma  remained  highly  prevalent.  (5)  Age  had  a  more  robust  modification  effect  in  younger  HIV  patients  compared  to  the  non-HIV  population  of  same  age  range.  Implications:  This  study  both  identified  the  pivotal  role  of  health-related  social  needs  in  hospital  readmission  and  elucidated  cancer  disparities  in  PLWH.  It  is  imperative  for  healthcare  providers  and  policymakers  to  acknowledge  social  factors  as  critical  in  reducing  hospital  readmissions  for  HIV  patients.  Recognizing  cancer  disparities  is  essential  for  developing  targeted  interventions  and  improving  healthcare  outcomes  for  both  men  and  women  living  with  HIV.  Initiating  HPV  vaccination  for  anal  and  cervical  cancer  should  target  adolescents  and  young  adults  among  HIV  patients.  Additionally,  cancer  prevention  and  screening  should  prioritize  high-risk  minority  PLWH  from  an  early  age.
■590    ▼aSchool  code:  0042.
■650  4▼aEpidemiology
■650  4▼aHealth  sciences
■650  4▼aImmunology
■653    ▼aHealth-related  social  needs
■653    ▼aState  Inpatient  Databases
■653    ▼aHuman  Immunodeficiency  Virus
■690    ▼a0766
■690    ▼a0566
■690    ▼a0982
■690    ▼a0769
■71020▼aCase  Western  Reserve  University▼bClinical  Research.
■7730  ▼tDissertations  Abstracts  International▼g86-12B.
■790    ▼a0042
■791    ▼aPh.D.
■792    ▼a2024
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17358636▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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