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Quantitative Ultrasound Characterization of Cervical Remodeling Through Advances in First-Order Speckle Statistics
Quantitative Ultrasound Characterization of Cervical Remodeling Through Advances in First-Order Speckle Statistics
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105136
- ISBN
- 9798293807222
- DDC
- 616
- 서명/저자
- Quantitative Ultrasound Characterization of Cervical Remodeling Through Advances in First-Order Speckle Statistics
- 발행사항
- [Sl] : The University of Wisconsin - Madison, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 195 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-03, Section: B.
- 주기사항
- Advisor: Hall, Timothy J.;Rosado-Mendez, Ivan M.
- 학위논문주기
- Thesis (Ph.D.)--The University of Wisconsin - Madison, 2025.
- 초록/해제
- 요약Preterm birth affects one in ten pregnancies worldwide and is associated with increased risk of developmental delays, early childhood death, and adverse health outcomes throughout life. Researchers and clinicians have called for early pregnancy biomarkers of preterm delivery, especially in the uterine cervix, a crucial component in the timing of delivery. Our goal is to refine quantitative ultrasound methods to characterize the remodeling microstructure of the cervix throughout gestation. First-order speckle statistics analysis is a quantitative ultrasound technique that can be used to make inferences about acoustic scatterers smaller than the image resolution. Challenges for speckle analysis of the cervix include high, spatially heterogeneous attenuation, system-dependence, and a lack of models for elongated components of the microstructure like fibrillar collagen - a prominent acoustic scatterer responsible for maintaining cervical strength. Therefore, methods for overcoming these challenges are developed and tested to compensate received signals for the expected power loss from attenuation and diffraction, to reduce the dependence of speckle statistics estimates on device-specific focal properties, and to establish a method for interpreting speckle statistics estimates from fibrous scatterers. Finally, speckle statistics analysis was performed in an in vivo human cohort in a longitudinal study of the cervix throughout pregnancy. This work establishes methods that will be beneficial in research and clinical implementation of speckle statistics, and it represents a unique lens into the microstructural remodeling of the in vivo cervix during gestation.
- 일반주제명
- Medical imaging
- 일반주제명
- Obstetrics
- 일반주제명
- Acoustics
- 일반주제명
- Biostatistics
- 키워드
- Preterm birth
- 키워드
- Ultrasonography
- 기타저자
- The University of Wisconsin - Madison Medical Physics
- 기본자료저록
- Dissertations Abstracts International. 87-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520260202105136
■006m o d
■007cr#unu||||||||
■020 ▼a9798293807222
■035 ▼a(MiAaPQ)AAI32239807
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aChristensen, Alexandra M.
■24510▼aQuantitative Ultrasound Characterization of Cervical Remodeling Through Advances in First-Order Speckle Statistics
■260 ▼a[Sl]▼bThe University of Wisconsin - Madison▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a195 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-03, Section: B.
■500 ▼aAdvisor: Hall, Timothy J.;Rosado-Mendez, Ivan M.
■5021 ▼aThesis (Ph.D.)--The University of Wisconsin - Madison, 2025.
■520 ▼aPreterm birth affects one in ten pregnancies worldwide and is associated with increased risk of developmental delays, early childhood death, and adverse health outcomes throughout life. Researchers and clinicians have called for early pregnancy biomarkers of preterm delivery, especially in the uterine cervix, a crucial component in the timing of delivery. Our goal is to refine quantitative ultrasound methods to characterize the remodeling microstructure of the cervix throughout gestation. First-order speckle statistics analysis is a quantitative ultrasound technique that can be used to make inferences about acoustic scatterers smaller than the image resolution. Challenges for speckle analysis of the cervix include high, spatially heterogeneous attenuation, system-dependence, and a lack of models for elongated components of the microstructure like fibrillar collagen - a prominent acoustic scatterer responsible for maintaining cervical strength. Therefore, methods for overcoming these challenges are developed and tested to compensate received signals for the expected power loss from attenuation and diffraction, to reduce the dependence of speckle statistics estimates on device-specific focal properties, and to establish a method for interpreting speckle statistics estimates from fibrous scatterers. Finally, speckle statistics analysis was performed in an in vivo human cohort in a longitudinal study of the cervix throughout pregnancy. This work establishes methods that will be beneficial in research and clinical implementation of speckle statistics, and it represents a unique lens into the microstructural remodeling of the in vivo cervix during gestation.
■590 ▼aSchool code: 0262.
■650 4▼aMedical imaging
■650 4▼aObstetrics
■650 4▼aAcoustics
■650 4▼aBiostatistics
■653 ▼aCervical remodeling
■653 ▼aPreterm birth
■653 ▼aQuantitative ultrasound
■653 ▼aSpeckle statistics
■653 ▼aUltrasonography
■690 ▼a0574
■690 ▼a0380
■690 ▼a0986
■690 ▼a0308
■71020▼aThe University of Wisconsin - Madison▼bMedical Physics.
■7730 ▼tDissertations Abstracts International▼g87-03B.
■790 ▼a0262
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359546▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
