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Salmonella Persistence in Diverse Intracellular and Physiological Contexts
Salmonella Persistence in Diverse Intracellular and Physiological Contexts
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105136
- ISBN
- 9798265408471
- DDC
- 576
- 서명/저자
- Salmonella Persistence in Diverse Intracellular and Physiological Contexts
- 발행사항
- [Sl] : Harvard University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 153 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-05, Section: B.
- 주기사항
- Advisor: Helaine, Sophie.
- 학위논문주기
- Thesis (Ph.D.)--Harvard University, 2025.
- 초록/해제
- 요약Antibiotic-recalcitrant infections, defined as the prolonged carriage of pathogenic bacteria even in the presence of antibiotics, are often caused by bacteria that are genetically susceptible to the drug. These recalcitrant bacteria fail to proliferate in the presence of antibiotics but remain viable such that they may recolonize their niche following antibiotic withdrawal. In the context of Salmonella infections, these antibiotic-recalcitrant infections are commonly caused by persisters, a non-growing, metabolically active bacterial subpopulation. Although much progress has been made in the study of persistent Salmonella, it remains unclear whether persister cells are the true source of relapsing disease, and whether other relevant intracellular persistence niches exist in addition to macrophages. In Chapter 1, I will provide a comprehensive overview of what is currently understood about antibiotic recalcitrance during Salmonella infection, including areas of active investigation. In Chapter 2, I will specifically explore the role of persister cells in infection relapse using the novel application of two methods to identify the source and nature of infection relapse. Then, in Chapter 3, I will discuss how we identified dendritic cells as an underappreciated niche for Salmonella persistence, and how the repeating O antigen moiety of lipopolysaccharide promotes persistence in both dendritic cells and macrophages by an as-yet unknown mechanism. Finally, Chapter 4 will summarize our broadened understanding of persistence and infection relapse and provide suggestions for future avenues of exploration. Through this dissertation and the work that will stem from it, we hope to gain a greater understanding of the mechanisms of infection relapse, allowing for more informed treatment decisions and a reduced incidence of recurrent disease.
- 일반주제명
- Microbiology
- 일반주제명
- Immunology
- 일반주제명
- Physiology
- 일반주제명
- Pathology
- 키워드
- Barcoding
- 키워드
- Dendritic cells
- 키워드
- Persistence
- 키워드
- Salmonella
- 키워드
- Antibiotics
- 기타저자
- Harvard University Biological and Biomedical Sciences
- 기본자료저록
- Dissertations Abstracts International. 87-05B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520260202105136
■006m o d
■007cr#unu||||||||
■020 ▼a9798265408471
■035 ▼a(MiAaPQ)AAI32239856
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a576
■1001 ▼aGiorgio, Rachel Teresa.
■24510▼aSalmonella Persistence in Diverse Intracellular and Physiological Contexts
■260 ▼a[Sl]▼bHarvard University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a153 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-05, Section: B.
■500 ▼aAdvisor: Helaine, Sophie.
■5021 ▼aThesis (Ph.D.)--Harvard University, 2025.
■520 ▼aAntibiotic-recalcitrant infections, defined as the prolonged carriage of pathogenic bacteria even in the presence of antibiotics, are often caused by bacteria that are genetically susceptible to the drug. These recalcitrant bacteria fail to proliferate in the presence of antibiotics but remain viable such that they may recolonize their niche following antibiotic withdrawal. In the context of Salmonella infections, these antibiotic-recalcitrant infections are commonly caused by persisters, a non-growing, metabolically active bacterial subpopulation. Although much progress has been made in the study of persistent Salmonella, it remains unclear whether persister cells are the true source of relapsing disease, and whether other relevant intracellular persistence niches exist in addition to macrophages. In Chapter 1, I will provide a comprehensive overview of what is currently understood about antibiotic recalcitrance during Salmonella infection, including areas of active investigation. In Chapter 2, I will specifically explore the role of persister cells in infection relapse using the novel application of two methods to identify the source and nature of infection relapse. Then, in Chapter 3, I will discuss how we identified dendritic cells as an underappreciated niche for Salmonella persistence, and how the repeating O antigen moiety of lipopolysaccharide promotes persistence in both dendritic cells and macrophages by an as-yet unknown mechanism. Finally, Chapter 4 will summarize our broadened understanding of persistence and infection relapse and provide suggestions for future avenues of exploration. Through this dissertation and the work that will stem from it, we hope to gain a greater understanding of the mechanisms of infection relapse, allowing for more informed treatment decisions and a reduced incidence of recurrent disease.
■590 ▼aSchool code: 0084.
■650 4▼aMicrobiology
■650 4▼aImmunology
■650 4▼aPhysiology
■650 4▼aPathology
■653 ▼aBarcoding
■653 ▼aDendritic cells
■653 ▼aPersistence
■653 ▼aSalmonella
■653 ▼aAntibiotics
■690 ▼a0410
■690 ▼a0982
■690 ▼a0719
■690 ▼a0571
■71020▼aHarvard University▼bBiological and Biomedical Sciences.
■7730 ▼tDissertations Abstracts International▼g87-05B.
■790 ▼a0084
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359549▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
