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Engineering Affinity-Based Sensing Systems for Continuous Biomolecular Monitoring
Engineering Affinity-Based Sensing Systems for Continuous Biomolecular Monitoring
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105312
- ISBN
- 9798270228286
- DDC
- 543
- 서명/저자
- Engineering Affinity-Based Sensing Systems for Continuous Biomolecular Monitoring
- 발행사항
- [Sl] : Northwestern University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 190 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-06, Section: B.
- 주기사항
- Advisor: Kelley, Shana O.
- 학위논문주기
- Thesis (Ph.D.)--Northwestern University, 2025.
- 초록/해제
- 요약Continuous biomolecular monitoring remains among the most captivating and elusive goals of modern analytical science, with the potential to revolutionize both the understanding and treatment of human disease. However, despite decades of innovation in analyte recognition, sensor transduction, and material interfacing, glucose remains the only molecular target that can be continuously and reliably monitored in vivo. While glucose detection was perfected owing largely to its compatibility with enzymatic sensing, the reliance of other analytes on affinity-based recognition elements has introduced a host of challenges related to receptor reversibility, stability, and sensitivity. The development of molecular pendulum sensing offers a reagent less, electrochemical method for direct protein quantification that begins to address several of these limitations, though important challenges remain. In this thesis, the expansion and refinement of molecular pendulum-based sensing is explored with a particular focus on identifying design principles that enable continuous biomolecular analysis. A combination of electrochemical experimentation, biomolecular engineering, and computational analysis was used to investigate how factors such as pendulum probe composition, geometry, and environment can be harnessed to enhance sensitivity, improve sensor lifetime, and expand molecular recognition to new classes of targets. In addition, affinity-based recognition elements were explored for their compatibility, whether natural or engineered, with continuous biomolecular monitoring applications. Through these efforts, important relationships between molecular design, binding kinetics, redox behavior, and electrochemical modulation were uncovered, establishing a more generalizable framework for improved affinity-based sensing.
- 일반주제명
- Analytical chemistry
- 일반주제명
- Chemistry
- 일반주제명
- Biochemistry
- 일반주제명
- Chemical engineering
- 키워드
- Biosensing
- 키워드
- Electrochemistry
- 키워드
- Biosensors
- 기타저자
- Northwestern University Chemistry
- 기본자료저록
- Dissertations Abstracts International. 87-06B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520260202105312
■006m o d
■007cr#unu||||||||
■020 ▼a9798270228286
■035 ▼a(MiAaPQ)AAI32285062
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a543
■1001 ▼aFlynn, Connor Daniel.
■24510▼aEngineering Affinity-Based Sensing Systems for Continuous Biomolecular Monitoring
■260 ▼a[Sl]▼bNorthwestern University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a190 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-06, Section: B.
■500 ▼aAdvisor: Kelley, Shana O.
■5021 ▼aThesis (Ph.D.)--Northwestern University, 2025.
■520 ▼aContinuous biomolecular monitoring remains among the most captivating and elusive goals of modern analytical science, with the potential to revolutionize both the understanding and treatment of human disease. However, despite decades of innovation in analyte recognition, sensor transduction, and material interfacing, glucose remains the only molecular target that can be continuously and reliably monitored in vivo. While glucose detection was perfected owing largely to its compatibility with enzymatic sensing, the reliance of other analytes on affinity-based recognition elements has introduced a host of challenges related to receptor reversibility, stability, and sensitivity. The development of molecular pendulum sensing offers a reagent less, electrochemical method for direct protein quantification that begins to address several of these limitations, though important challenges remain. In this thesis, the expansion and refinement of molecular pendulum-based sensing is explored with a particular focus on identifying design principles that enable continuous biomolecular analysis. A combination of electrochemical experimentation, biomolecular engineering, and computational analysis was used to investigate how factors such as pendulum probe composition, geometry, and environment can be harnessed to enhance sensitivity, improve sensor lifetime, and expand molecular recognition to new classes of targets. In addition, affinity-based recognition elements were explored for their compatibility, whether natural or engineered, with continuous biomolecular monitoring applications. Through these efforts, important relationships between molecular design, binding kinetics, redox behavior, and electrochemical modulation were uncovered, establishing a more generalizable framework for improved affinity-based sensing.
■590 ▼aSchool code: 0163.
■650 4▼aAnalytical chemistry
■650 4▼aChemistry
■650 4▼aBiochemistry
■650 4▼aChemical engineering
■653 ▼aBiosensing
■653 ▼aContinuous monitoring
■653 ▼aElectrochemistry
■653 ▼aBiomolecular engineering
■653 ▼aBiosensors
■690 ▼a0486
■690 ▼a0487
■690 ▼a0542
■690 ▼a0485
■71020▼aNorthwestern University▼bChemistry.
■7730 ▼tDissertations Abstracts International▼g87-06B.
■790 ▼a0163
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17360157▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
