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Refinement of the Novel Preference Paradigm for Young Pigs
Refinement of the Novel Preference Paradigm for Young Pigs
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105704
- ISBN
- 9798263308131
- DDC
- 616
- 서명/저자
- Refinement of the Novel Preference Paradigm for Young Pigs
- 발행사항
- [Sl] : University of Illinois at Urbana-Champaign, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 245 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-05, Section: B.
- 주기사항
- Advisor: Dilger, Ryan N.
- 학위논문주기
- Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2024.
- 초록/해제
- 요약There are many reasons why human infants may rely on infant formula instead of breastmilk. Unfortunately, evidence has demonstrated discrepancies between formula-fed and breastfed infants, with breastfed infants outperforming their formula-fed peers in cognitive development. As such, formula companies are working to enhance their products with the goal of reducing that developmental gap. One of the main components of breastmilk is oligosaccharides, which have been shown to support intestinal, brain, and cognitive development. Infant formulas are typically formulated using bovine milk, which contains lower levels and different forms of oligosaccharides than breastmilk. As such, formula companies are funding research assessing the impact of oligosaccharide supplementation, especially in sialylated form. The pig as a biomedical model has grown more popular in recent years due to the similarities to humans, with the main similarities revolving around neuroanatomy and gastrointestinal physiology. The work in this dissertation set out to determine the impact of sialyllactose supplementation on intestinal, brain, and cognitive development. Additionally, updates were made to the main behavior test used to assess cognitive development in order to reduce data variability and increase paradigm sensitivity.We demonstrated that sialyllactose supplementation is safe and well-tolerated by the growing pig. This work also indicated minor behavioral, physiological, and anatomical differences due to supplementation. Additional work demonstrated that pigs are able to demonstrate recognition memory utilizing proper paradigm hardware and analysis techniques. The results from this work should inform future research of nutritional interventions and provide insight as to best-practices for elucidating cognitive differences in growing pigs.
- 일반주제명
- Neurosciences
- 일반주제명
- Animal sciences
- 일반주제명
- Medicine
- 키워드
- Biomedical model
- 키워드
- Breastmilk
- 기타저자
- University of Illinois at Urbana-Champaign Neuroscience Program
- 기본자료저록
- Dissertations Abstracts International. 87-05B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798263308131
■035 ▼a(MiAaPQ)AAI32409902
■035 ▼a(MiAaPQ)124202
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aGolden, Rebecca Kirsten.
■24510▼aRefinement of the Novel Preference Paradigm for Young Pigs
■260 ▼a[Sl]▼bUniversity of Illinois at Urbana-Champaign▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a245 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-05, Section: B.
■500 ▼aAdvisor: Dilger, Ryan N.
■5021 ▼aThesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2024.
■520 ▼aThere are many reasons why human infants may rely on infant formula instead of breastmilk. Unfortunately, evidence has demonstrated discrepancies between formula-fed and breastfed infants, with breastfed infants outperforming their formula-fed peers in cognitive development. As such, formula companies are working to enhance their products with the goal of reducing that developmental gap. One of the main components of breastmilk is oligosaccharides, which have been shown to support intestinal, brain, and cognitive development. Infant formulas are typically formulated using bovine milk, which contains lower levels and different forms of oligosaccharides than breastmilk. As such, formula companies are funding research assessing the impact of oligosaccharide supplementation, especially in sialylated form. The pig as a biomedical model has grown more popular in recent years due to the similarities to humans, with the main similarities revolving around neuroanatomy and gastrointestinal physiology. The work in this dissertation set out to determine the impact of sialyllactose supplementation on intestinal, brain, and cognitive development. Additionally, updates were made to the main behavior test used to assess cognitive development in order to reduce data variability and increase paradigm sensitivity.We demonstrated that sialyllactose supplementation is safe and well-tolerated by the growing pig. This work also indicated minor behavioral, physiological, and anatomical differences due to supplementation. Additional work demonstrated that pigs are able to demonstrate recognition memory utilizing proper paradigm hardware and analysis techniques. The results from this work should inform future research of nutritional interventions and provide insight as to best-practices for elucidating cognitive differences in growing pigs.
■590 ▼aSchool code: 0090.
■650 4▼aNeurosciences
■650 4▼aAnimal sciences
■650 4▼aMedicine
■653 ▼aBehavioral neuroscience
■653 ▼aCognitive development
■653 ▼aBiomedical model
■653 ▼aBreastmilk
■690 ▼a0317
■690 ▼a0475
■690 ▼a0564
■690 ▼a0778
■71020▼aUniversity of Illinois at Urbana-Champaign▼bNeuroscience Program.
■7730 ▼tDissertations Abstracts International▼g87-05B.
■790 ▼a0090
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17361087▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
