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Refinement of the Novel Preference Paradigm for Young Pigs
Refinement of the Novel Preference Paradigm for Young Pigs
Refinement of the Novel Preference Paradigm for Young Pigs

Detailed Information

자료유형  
 학위논문 서양
최종처리일시  
20260202105704
ISBN  
9798263308131
DDC  
616
저자명  
Golden, Rebecca Kirsten.
서명/저자  
Refinement of the Novel Preference Paradigm for Young Pigs
발행사항  
[Sl] : University of Illinois at Urbana-Champaign, 2024
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2024
형태사항  
245 p
주기사항  
Source: Dissertations Abstracts International, Volume: 87-05, Section: B.
주기사항  
Advisor: Dilger, Ryan N.
학위논문주기  
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2024.
초록/해제  
요약There are many reasons why human infants may rely on infant formula instead of breastmilk. Unfortunately, evidence has demonstrated discrepancies between formula-fed and breastfed infants, with breastfed infants outperforming their formula-fed peers in cognitive development. As such, formula companies are working to enhance their products with the goal of reducing that developmental gap. One of the main components of breastmilk is oligosaccharides, which have been shown to support intestinal, brain, and cognitive development. Infant formulas are typically formulated using bovine milk, which contains lower levels and different forms of oligosaccharides than breastmilk. As such, formula companies are funding research assessing the impact of oligosaccharide supplementation, especially in sialylated form. The pig as a biomedical model has grown more popular in recent years due to the similarities to humans, with the main similarities revolving around neuroanatomy and gastrointestinal physiology. The work in this dissertation set out to determine the impact of sialyllactose supplementation on intestinal, brain, and cognitive development. Additionally, updates were made to the main behavior test used to assess cognitive development in order to reduce data variability and increase paradigm sensitivity.We demonstrated that sialyllactose supplementation is safe and well-tolerated by the growing pig. This work also indicated minor behavioral, physiological, and anatomical differences due to supplementation. Additional work demonstrated that pigs are able to demonstrate recognition memory utilizing proper paradigm hardware and analysis techniques. The results from this work should inform future research of nutritional interventions and provide insight as to best-practices for elucidating cognitive differences in growing pigs.
일반주제명  
Neurosciences
일반주제명  
Animal sciences
일반주제명  
Medicine
키워드  
Behavioral neuroscience
키워드  
Cognitive development
키워드  
Biomedical model
키워드  
Breastmilk
기타저자  
University of Illinois at Urbana-Champaign Neuroscience Program
기본자료저록  
Dissertations Abstracts International. 87-05B.
전자적 위치 및 접속  
로그인 후 원문을 볼 수 있습니다.

MARC

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■1001  ▼aGolden,  Rebecca  Kirsten.
■24510▼aRefinement  of  the  Novel  Preference  Paradigm  for  Young  Pigs
■260    ▼a[Sl]▼bUniversity  of  Illinois  at  Urbana-Champaign▼c2024
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2024
■300    ▼a245  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  87-05,  Section:  B.
■500    ▼aAdvisor:  Dilger,  Ryan  N.
■5021  ▼aThesis  (Ph.D.)--University  of  Illinois  at  Urbana-Champaign,  2024.
■520    ▼aThere  are  many  reasons  why  human  infants  may  rely  on  infant  formula  instead  of  breastmilk.  Unfortunately,  evidence  has  demonstrated  discrepancies  between  formula-fed  and  breastfed  infants,  with  breastfed  infants  outperforming  their  formula-fed  peers  in  cognitive  development.  As  such,  formula  companies  are  working  to  enhance  their  products  with  the  goal  of  reducing  that  developmental  gap.  One  of  the  main  components  of  breastmilk  is  oligosaccharides,  which  have  been  shown  to  support  intestinal,  brain,  and  cognitive  development.  Infant  formulas  are  typically  formulated  using  bovine  milk,  which  contains  lower  levels  and  different  forms  of  oligosaccharides  than  breastmilk.  As  such,  formula  companies  are  funding  research  assessing  the  impact  of  oligosaccharide  supplementation,  especially  in  sialylated  form.  The  pig  as  a  biomedical  model  has  grown  more  popular  in  recent  years  due  to  the  similarities  to  humans,  with  the  main  similarities  revolving  around  neuroanatomy  and  gastrointestinal  physiology.  The  work  in  this  dissertation  set  out  to  determine  the  impact  of  sialyllactose  supplementation  on  intestinal,  brain,  and  cognitive  development.  Additionally,  updates  were  made  to  the  main  behavior  test  used  to  assess  cognitive  development  in  order  to  reduce  data  variability  and  increase  paradigm  sensitivity.We  demonstrated  that  sialyllactose  supplementation  is  safe  and  well-tolerated  by  the  growing  pig.  This  work  also  indicated  minor  behavioral,  physiological,  and  anatomical  differences  due  to  supplementation.  Additional  work  demonstrated  that  pigs  are  able  to  demonstrate  recognition  memory  utilizing  proper  paradigm  hardware  and  analysis  techniques.  The  results  from  this  work  should  inform  future  research  of  nutritional  interventions  and  provide  insight  as  to  best-practices  for  elucidating  cognitive  differences  in  growing  pigs.
■590    ▼aSchool  code:  0090.
■650  4▼aNeurosciences
■650  4▼aAnimal  sciences
■650  4▼aMedicine
■653    ▼aBehavioral  neuroscience
■653    ▼aCognitive  development
■653    ▼aBiomedical  model
■653    ▼aBreastmilk
■690    ▼a0317
■690    ▼a0475
■690    ▼a0564
■690    ▼a0778
■71020▼aUniversity  of  Illinois  at  Urbana-Champaign▼bNeuroscience  Program.
■7730  ▼tDissertations  Abstracts  International▼g87-05B.
■790    ▼a0090
■791    ▼aPh.D.
■792    ▼a2024
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17361087▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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