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Minimally-Invasive Dentistry via Dual-Function Novel Bioactive Low-Shrinkage-Stress Flowable Nanocomposite
Minimally-Invasive Dentistry via Dual-Function Novel Bioactive Low-Shrinkage-Stress Flowable Nanocomposite
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260209102832
- ISBN
- 9798315743538
- DDC
- 617.6
- 서명/저자
- Minimally-Invasive Dentistry via Dual-Function Novel Bioactive Low-Shrinkage-Stress Flowable Nanocomposite
- 발행사항
- [Sl] : University of Maryland, Baltimore, 2023
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2023
- 형태사항
- 132 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-11, Section: B.
- 주기사항
- Advisor: Xu, Huakun.
- 학위논문주기
- Thesis (Ph.D.)--University of Maryland, Baltimore, 2023.
- 초록/해제
- 요약The objectives of the in vitro studies were to develop a novel low-shrinkage-stress flowable nanocomposite with antibacterial properties through the incorporation of dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP) or calcium fluoride CaF2, and investigate the mechanical and oral biofilm properties, to be used in minimally-invasive techniques. Methods: The light-cured low-shrinkage-stress flowable resin was formulated by mixing urethane dimethacrylate (UDMA) and triethylene glycol divinylbenzyl ether (TEG-DVBE) at a 1:1 mass ratio. Different mass fractions of glass, and either 3-5% DMAHDM, 20%NACP, 20% CaF2 or two of the additives were incorporated. Paste flowability, mechanical properties and surface roughness were evaluated. The antibacterial response of DMAHDM resin was assessed by using biofilms of human saliva-derived microcosm model. Virtuoso flowable composite was used as a control. Results: (45% resin+5% DMAHDM+20% NACP+30% glass) and (47% resin+3% DMAHDM+20% nCaF2+30% glass) formulas yielded the needed outcomes. It had flow rate within the range of ISO requirement. The mechanical strength test results were similar to the commercial control (p 0.05). The surface roughness values of the novel composites (0.079 짹 0.01) 쨉m similar to commercial composite (0.09 짹 0.02) 쨉m (p 0.05). S.mutans and salivary microcosm biofilm colony forming unit values were reduced by 5-6 logs (p 0.05). Biofilm metabolic activity tests were also substantially reduced, compared to control composite (p 0.05).Significance: The novel bioactive flowable nanocomposite achieved strong antibacterial activities without compromising the mechanical properties. It is promising to be used as pit and fissure sealants, and as fillings in conservative cavities to inhibit recurrent caries and increase restoration longevity.
- 일반주제명
- Dentistry
- 일반주제명
- Materials science
- 일반주제명
- Nanoscience
- 일반주제명
- Mechanical engineering
- 키워드
- Antibacterial
- 키워드
- Biofilm
- 키워드
- Dental materials
- 키워드
- Nanoparticles
- 키워드
- Restoration
- 기타저자
- University of Maryland, Baltimore Biomedical Sciences-Dental School
- 기본자료저록
- Dissertations Abstracts International. 86-11B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008260203s2023 us c eng d■001000017365827
■00520260209102832
■006m o d
■007cr#unu||||||||
■020 ▼a9798315743538
■035 ▼a(MiAaPQ)AAI30568352
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a617.6
■1001 ▼aAlbeshir, Ebtehal Ghasan.
■24510▼aMinimally-Invasive Dentistry via Dual-Function Novel Bioactive Low-Shrinkage-Stress Flowable Nanocomposite
■260 ▼a[Sl]▼bUniversity of Maryland, Baltimore▼c2023
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2023
■300 ▼a132 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-11, Section: B.
■500 ▼aAdvisor: Xu, Huakun.
■5021 ▼aThesis (Ph.D.)--University of Maryland, Baltimore, 2023.
■520 ▼aThe objectives of the in vitro studies were to develop a novel low-shrinkage-stress flowable nanocomposite with antibacterial properties through the incorporation of dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP) or calcium fluoride CaF2, and investigate the mechanical and oral biofilm properties, to be used in minimally-invasive techniques. Methods: The light-cured low-shrinkage-stress flowable resin was formulated by mixing urethane dimethacrylate (UDMA) and triethylene glycol divinylbenzyl ether (TEG-DVBE) at a 1:1 mass ratio. Different mass fractions of glass, and either 3-5% DMAHDM, 20%NACP, 20% CaF2 or two of the additives were incorporated. Paste flowability, mechanical properties and surface roughness were evaluated. The antibacterial response of DMAHDM resin was assessed by using biofilms of human saliva-derived microcosm model. Virtuoso flowable composite was used as a control. Results: (45% resin+5% DMAHDM+20% NACP+30% glass) and (47% resin+3% DMAHDM+20% nCaF2+30% glass) formulas yielded the needed outcomes. It had flow rate within the range of ISO requirement. The mechanical strength test results were similar to the commercial control (p 0.05). The surface roughness values of the novel composites (0.079 짹 0.01) 쨉m similar to commercial composite (0.09 짹 0.02) 쨉m (p 0.05). S.mutans and salivary microcosm biofilm colony forming unit values were reduced by 5-6 logs (p 0.05). Biofilm metabolic activity tests were also substantially reduced, compared to control composite (p 0.05).Significance: The novel bioactive flowable nanocomposite achieved strong antibacterial activities without compromising the mechanical properties. It is promising to be used as pit and fissure sealants, and as fillings in conservative cavities to inhibit recurrent caries and increase restoration longevity.
■590 ▼aSchool code: 0373.
■650 4▼aDentistry
■650 4▼aMaterials science
■650 4▼aNanoscience
■650 4▼aMechanical engineering
■653 ▼aAntibacterial
■653 ▼aBiofilm
■653 ▼aDental materials
■653 ▼aLow shrinkage stress
■653 ▼aNanoparticles
■653 ▼aRestoration
■690 ▼a0567
■690 ▼a0565
■690 ▼a0794
■690 ▼a0548
■71020▼aUniversity of Maryland, Baltimore▼bBiomedical Sciences-Dental School.
■7730 ▼tDissertations Abstracts International▼g86-11B.
■790 ▼a0373
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17365827▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
