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Predicting Phase Behaviors of Biomolecular Condensates Using Minimal Models
Predicting Phase Behaviors of Biomolecular Condensates Using Minimal Models
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202103521
- ISBN
- 9798280747357
- DDC
- 574.191
- 저자명
- Li, Tianhao.
- 서명/저자
- Predicting Phase Behaviors of Biomolecular Condensates Using Minimal Models
- 발행사항
- [Sl] : Princeton University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 182 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
- 주기사항
- Advisor: Jacobs, William M.
- 학위논문주기
- Thesis (Ph.D.)--Princeton University, 2025.
- 초록/해제
- 요약Biomolecular condensates are membraneless compartments within living cells that play crucial roles in organizing cellular processes. Understanding their formation, function, and regulation has significant implications for elucidating biological processes and developing treatments for neurodegenerative diseases such as Alzheimer's. These condensates are widely believed to form through liquid-liquid phase separation (LLPS), driven by attractive molecular interactions. Predicting the phase behavior of biomolecular systems from these interactions remains a major challenge due to their inherent complexity. To address this, we introduced minimal models that capture essential features of biomolecular interactions. We developed simulation techniques and theoretical approaches to analyze these models. Our findings provide insights into the physical principles that govern phase separation, with potential applicability across a broad range of biomolecular systems.
- 일반주제명
- Biophysics
- 일반주제명
- Thermodynamics
- 일반주제명
- Physical chemistry
- 일반주제명
- Energy
- 일반주제명
- Biochemistry
- 키워드
- Free energy
- 키워드
- Phase separation
- 기타저자
- Princeton University Chemistry
- 기본자료저록
- Dissertations Abstracts International. 86-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■040 ▼aMiAaPQ▼cMiAaPQ
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■1001 ▼aLi, Tianhao.▼0(orcid)0009-0003-6129-0320
■24510▼aPredicting Phase Behaviors of Biomolecular Condensates Using Minimal Models
■260 ▼a[Sl]▼bPrinceton University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a182 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-12, Section: B.
■500 ▼aAdvisor: Jacobs, William M.
■5021 ▼aThesis (Ph.D.)--Princeton University, 2025.
■520 ▼aBiomolecular condensates are membraneless compartments within living cells that play crucial roles in organizing cellular processes. Understanding their formation, function, and regulation has significant implications for elucidating biological processes and developing treatments for neurodegenerative diseases such as Alzheimer's. These condensates are widely believed to form through liquid-liquid phase separation (LLPS), driven by attractive molecular interactions. Predicting the phase behavior of biomolecular systems from these interactions remains a major challenge due to their inherent complexity. To address this, we introduced minimal models that capture essential features of biomolecular interactions. We developed simulation techniques and theoretical approaches to analyze these models. Our findings provide insights into the physical principles that govern phase separation, with potential applicability across a broad range of biomolecular systems.
■590 ▼aSchool code: 0181.
■650 4▼aBiophysics
■650 4▼aThermodynamics
■650 4▼aPhysical chemistry
■650 4▼aEnergy
■650 4▼aBiochemistry
■653 ▼aBiomolecular condensates
■653 ▼aFree energy
■653 ▼aPhase separation
■653 ▼aLiquid-liquid phase separation
■653 ▼aBiomolecular interactions
■690 ▼a0786
■690 ▼a0348
■690 ▼a0494
■690 ▼a0487
■690 ▼a0791
■71020▼aPrinceton University▼bChemistry.
■7730 ▼tDissertations Abstracts International▼g86-12B.
■790 ▼a0181
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17357505▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
