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Programmable Self-Assembly of Multiphasic Liquids and Solids
Programmable Self-Assembly of Multiphasic Liquids and Solids
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202103514
- ISBN
- 9798280747661
- DDC
- 574.191
- 저자명
- Chen, Fan.
- 서명/저자
- Programmable Self-Assembly of Multiphasic Liquids and Solids
- 발행사항
- [Sl] : Princeton University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 131 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
- 주기사항
- Advisor: Jacobs, William M.
- 학위논문주기
- Thesis (Ph.D.)--Princeton University, 2025.
- 초록/해제
- 요약In nature, molecules spontaneously self-assemble into functional materials, driving much of the complexity observed in soft matter systems. While near-equilibrium assembly processes are governed largely by thermodynamics, kinetic effects become increasingly important in out-of-equilibrium settings. Although prior work has probed the interplay of thermodynamics and kinetics in few-component systems, much remains unknown about these processes in complex multicomponent systems.This thesis explores two contrasting aspects of multicomponent self-assembly. First, it investigates near-equilibrium liquid-liquid phase separation (LLPS), which leads to the formation of immiscible molecular condensates within cells. To understand how such multiphase coexistence can emerge from limited chemical specificity, an inverse design framework is introduced for computing the minimum required interaction specificity to assemble target condensates. An accompanying algorithm further demonstrates how complex, artificial multiphase systems can be engineered from simple chemical building blocks. These theoretical results are validated by designing heteropolymer sequences that produce multiple coexisting condensates with prescribed compositions.In the second part, the thesis addresses out-of-equilibrium assembly in multicomponent polymorphic systems. By examining a reversible growth process, this work reveals a first-order dynamical phase transition as a new failure mode for assembly of multicomponent polymorphic materials, in which dynamical coexistence occurs between ordered and disordered assembly. The results underscore the necessity of considering both thermodynamics and kinetics to advance the design of complex, multifunctional materials. Taken together, these studies offer complementary perspectives on self-assembly and deepen our understanding of how rich phase behavior and morphological diversity can emerge in multicomponent systems.
- 일반주제명
- Biophysics
- 일반주제명
- Physical chemistry
- 일반주제명
- Materials science
- 일반주제명
- Thermodynamics
- 일반주제명
- Polymer chemistry
- 키워드
- Self-assembly
- 키워드
- Equilibrium
- 기타저자
- Princeton University Electrical and Computer Engineering
- 기본자료저록
- Dissertations Abstracts International. 86-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■006m o d
■007cr#unu||||||||
■020 ▼a9798280747661
■035 ▼a(MiAaPQ)AAI32037959
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574.191
■1001 ▼aChen, Fan.▼0(orcid)0000000341193059
■24510▼aProgrammable Self-Assembly of Multiphasic Liquids and Solids
■260 ▼a[Sl]▼bPrinceton University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a131 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-12, Section: B.
■500 ▼aAdvisor: Jacobs, William M.
■5021 ▼aThesis (Ph.D.)--Princeton University, 2025.
■520 ▼aIn nature, molecules spontaneously self-assemble into functional materials, driving much of the complexity observed in soft matter systems. While near-equilibrium assembly processes are governed largely by thermodynamics, kinetic effects become increasingly important in out-of-equilibrium settings. Although prior work has probed the interplay of thermodynamics and kinetics in few-component systems, much remains unknown about these processes in complex multicomponent systems.This thesis explores two contrasting aspects of multicomponent self-assembly. First, it investigates near-equilibrium liquid-liquid phase separation (LLPS), which leads to the formation of immiscible molecular condensates within cells. To understand how such multiphase coexistence can emerge from limited chemical specificity, an inverse design framework is introduced for computing the minimum required interaction specificity to assemble target condensates. An accompanying algorithm further demonstrates how complex, artificial multiphase systems can be engineered from simple chemical building blocks. These theoretical results are validated by designing heteropolymer sequences that produce multiple coexisting condensates with prescribed compositions.In the second part, the thesis addresses out-of-equilibrium assembly in multicomponent polymorphic systems. By examining a reversible growth process, this work reveals a first-order dynamical phase transition as a new failure mode for assembly of multicomponent polymorphic materials, in which dynamical coexistence occurs between ordered and disordered assembly. The results underscore the necessity of considering both thermodynamics and kinetics to advance the design of complex, multifunctional materials. Taken together, these studies offer complementary perspectives on self-assembly and deepen our understanding of how rich phase behavior and morphological diversity can emerge in multicomponent systems.
■590 ▼aSchool code: 0181.
■650 4▼aBiophysics
■650 4▼aPhysical chemistry
■650 4▼aMaterials science
■650 4▼aThermodynamics
■650 4▼aPolymer chemistry
■653 ▼aMulticomponent systems
■653 ▼aLiquid-liquid phase separation
■653 ▼aSelf-assembly
■653 ▼aEquilibrium
■653 ▼aPolymorphic systems
■690 ▼a0786
■690 ▼a0494
■690 ▼a0794
■690 ▼a0348
■690 ▼a0495
■71020▼aPrinceton University▼bElectrical and Computer Engineering.
■7730 ▼tDissertations Abstracts International▼g86-12B.
■790 ▼a0181
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17357452▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
