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1-D Mathematical Modeling to Study the Mechanics of Pregnancy and Preeclampsia, Lymphatics, And Peripheral Artery Disease
1-D Mathematical Modeling to Study the Mechanics of Pregnancy and Preeclampsia, Lymphatics, And Peripheral Artery Disease
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105518
- ISBN
- 9798263338626
- DDC
- 611.13
- 서명/저자
- 1-D Mathematical Modeling to Study the Mechanics of Pregnancy and Preeclampsia, Lymphatics, And Peripheral Artery Disease
- 발행사항
- [Sl] : Georgia Institute of Technology, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 207 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-05, Section: B.
- 주기사항
- Advisor: Gleason, Rudolph L.
- 학위논문주기
- Thesis (Ph.D.)--Georgia Institute of Technology, 2024.
- 초록/해제
- 요약The dissertation delves into the pivotal role of mathematical modeling in unraveling complex biological systems, ranging from cellular to organ levels. Despite extensive research, certain conditions like preeclampsia (PE), lymphedema, and peripheral arterial disease (PAD) remain insufficiently explored. These disorders are intricately linked to the mechanical environment, encompassing factors such as fluid transport, solid mechanical responses, and growth and remodeling mechanisms. For instance, in PE, compromised vascular remodeling of the uterine vasculature leads to reduced blood flow to the placenta, resulting in hypertension and related complications.Hemodynamics, crucial for normal physiological function, is often studied using mathematical models. While simpler models lack the capacity to capture axial wave behavior, higher-order models like 1-D models offer a balance between complexity and computational efficiency. These models account for spatial variations along each vessel axis, providing insights into cardiovascular regions with valves or bifurcations.The dissertation aims to assess the utility of employing 1-D mathematical models to investigate biological phenomena influenced by wall phenotype, such as during pregnancy. The objective is to validate whether these models, coupled with established concepts like growth and remodeling, can analyze biological events where the vascular system significantly impacts fluid transport mechanisms. Ultimately, leveraging established mathematical frameworks and paradigms, the dissertation endeavors to provide valuable insights into the underlying mechanisms governing disease manifestations.
- 일반주제명
- Carotid arteries
- 일반주제명
- Physiology
- 일반주제명
- Vein & artery diseases
- 일반주제명
- Investigations
- 일반주제명
- Flow velocity
- 일반주제명
- Blood vessels
- 일반주제명
- Mathematical models
- 일반주제명
- Lymphedema
- 일반주제명
- Normal distribution
- 일반주제명
- Pregnancy complications
- 일반주제명
- Mechanics
- 일반주제명
- Boundary conditions
- 일반주제명
- Blood pressure
- 일반주제명
- Lymphatic system
- 일반주제명
- Coronary vessels
- 일반주제명
- Hypertension
- 일반주제명
- Hemodynamics
- 일반주제명
- Gestational age
- 일반주제명
- Fluid mechanics
- 일반주제명
- Mathematics
- 일반주제명
- Medicine
- 일반주제명
- Morphology
- 일반주제명
- Obstetrics
- 기본자료저록
- Dissertations Abstracts International. 87-05B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a611.13
■1001 ▼aSedaghati, Farbod.
■24510▼a1-D Mathematical Modeling to Study the Mechanics of Pregnancy and Preeclampsia, Lymphatics, And Peripheral Artery Disease
■260 ▼a[Sl]▼bGeorgia Institute of Technology▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a207 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-05, Section: B.
■500 ▼aAdvisor: Gleason, Rudolph L.
■5021 ▼aThesis (Ph.D.)--Georgia Institute of Technology, 2024.
■520 ▼aThe dissertation delves into the pivotal role of mathematical modeling in unraveling complex biological systems, ranging from cellular to organ levels. Despite extensive research, certain conditions like preeclampsia (PE), lymphedema, and peripheral arterial disease (PAD) remain insufficiently explored. These disorders are intricately linked to the mechanical environment, encompassing factors such as fluid transport, solid mechanical responses, and growth and remodeling mechanisms. For instance, in PE, compromised vascular remodeling of the uterine vasculature leads to reduced blood flow to the placenta, resulting in hypertension and related complications.Hemodynamics, crucial for normal physiological function, is often studied using mathematical models. While simpler models lack the capacity to capture axial wave behavior, higher-order models like 1-D models offer a balance between complexity and computational efficiency. These models account for spatial variations along each vessel axis, providing insights into cardiovascular regions with valves or bifurcations.The dissertation aims to assess the utility of employing 1-D mathematical models to investigate biological phenomena influenced by wall phenotype, such as during pregnancy. The objective is to validate whether these models, coupled with established concepts like growth and remodeling, can analyze biological events where the vascular system significantly impacts fluid transport mechanisms. Ultimately, leveraging established mathematical frameworks and paradigms, the dissertation endeavors to provide valuable insights into the underlying mechanisms governing disease manifestations.
■590 ▼aSchool code: 0078.
■650 4▼aCarotid arteries
■650 4▼aPhysiology
■650 4▼aVein & artery diseases
■650 4▼aInvestigations
■650 4▼aFlow velocity
■650 4▼aBlood vessels
■650 4▼aMathematical models
■650 4▼aLymphedema
■650 4▼aNormal distribution
■650 4▼aPregnancy complications
■650 4▼aMechanics
■650 4▼aBoundary conditions
■650 4▼aPartial differential equations
■650 4▼aBlood pressure
■650 4▼aLymphatic system
■650 4▼aCoronary vessels
■650 4▼aHypertension
■650 4▼aHemodynamics
■650 4▼aGestational age
■650 4▼aFluid mechanics
■650 4▼aMathematics
■650 4▼aMedicine
■650 4▼aMorphology
■650 4▼aObstetrics
■690 ▼a0346
■690 ▼a0719
■690 ▼a0204
■690 ▼a0405
■690 ▼a0564
■690 ▼a0287
■690 ▼a0380
■71020▼aGeorgia Institute of Technology.
■7730 ▼tDissertations Abstracts International▼g87-05B.
■790 ▼a0078
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17360394▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.


