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The Structural Development of Early Memory-Related Brain Networks and Their Relationship With Episodic Memory Performance: Implications for Perinatal Brain Insults
The Structural Development of Early Memory-Related Brain Networks and Their Relationship With Episodic Memory Performance: Implications for Perinatal Brain Insults
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202103623
- ISBN
- 9798270250010
- DDC
- 136
- 서명/저자
- The Structural Development of Early Memory-Related Brain Networks and Their Relationship With Episodic Memory Performance: Implications for Perinatal Brain Insults
- 발행사항
- [Sl] : University of Minnesota, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 120 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-06, Section: B.
- 주기사항
- Advisor: Thomas, Kathleen;Elison, Jed.
- 학위논문주기
- Thesis (Ph.D.)--University of Minnesota, 2025.
- 초록/해제
- 요약Little is known about the brain networks that support episodic memory development in the first years of life. Literature suggests that protracted growth of the hippocampus may relate to the susceptibility of regions in memory brain networks when exposed to perinatal insults, as well as to phenomenon such as infantile amnesia. Yet the role of structural development in these memory brain networks in episodic memory is not yet fully elucidated. In this dissertation, two studies were utilized to analyze how brain development and episodic memory are interrelated and how this development might be altered when infants are born prematurely. In 835 visits from 0-4 years of age across 322 participants in the Baby Connectome Project, MRI images were processed through an open-source segmentation pipeline, "BIBSNet". Hippocampal segmentations were further subdivided into head, body, and tail subregions manually for 426 visits, which were then used to train models to automatically segment the rest of the hippocampal subregions. Generalized additive mixed models (GAMMs) were then used to measure trajectories of development across the thalamus, amygdala, and subregions of the hippocampus. Trajectories of volume growth differed across regions and even across subregions within the hippocampus, with the head of the hippocampus showing steep growth that plateaued months later than the body or tail of the hippocampus. 58 participants from the BCP returned for a school-aged follow-up, including two episodic memory tasks. In the right head of the hippocampus, residuals from the GAMM-predicted volume positively predicted later performance on an episodic memory task. Using GAMMs that accounted for total brain volume, the right thalamus residuals also predicted memory performance. Total sleep duration at the school-aged visit accounted for variance above and beyond these brain volume correlations. 56 preterm-born and 55 age-matched 5-year-old full-term participants were recruited and performed the same episodic memory tasks as the BCP follow-up participants. No deficits were found in episodic memory performance for participants born preterm. An interaction was found between gestational age and sleep disturbance scores such that sleep disturbance only correlated with episodic memory performance in participants born preterm. Altogether, these results build on prior literature that suggests both the timing of growth and relationships with aspects of episodic memory performance are region and subregion specific. The relations between sleep and memory performance provide evidence for the important role of sleep in the relationship between brain networks and early episodic memory development. These results provide important information into the brain development underlying the development of episodic memory and how early trajectories of memory development might be influenced by insults to early brain development.
- 일반주제명
- Developmental psychology
- 일반주제명
- Neurosciences
- 일반주제명
- Cognitive psychology
- 키워드
- Brain networks
- 키워드
- MRI images
- 기타저자
- University of Minnesota Developmental Psychology
- 기본자료저록
- Dissertations Abstracts International. 87-06B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■1001 ▼aStoyell, Sally M.
■24510▼aThe Structural Development of Early Memory-Related Brain Networks and Their Relationship With Episodic Memory Performance: Implications for Perinatal Brain Insults
■260 ▼a[Sl]▼bUniversity of Minnesota▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a120 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-06, Section: B.
■500 ▼aAdvisor: Thomas, Kathleen;Elison, Jed.
■5021 ▼aThesis (Ph.D.)--University of Minnesota, 2025.
■520 ▼aLittle is known about the brain networks that support episodic memory development in the first years of life. Literature suggests that protracted growth of the hippocampus may relate to the susceptibility of regions in memory brain networks when exposed to perinatal insults, as well as to phenomenon such as infantile amnesia. Yet the role of structural development in these memory brain networks in episodic memory is not yet fully elucidated. In this dissertation, two studies were utilized to analyze how brain development and episodic memory are interrelated and how this development might be altered when infants are born prematurely. In 835 visits from 0-4 years of age across 322 participants in the Baby Connectome Project, MRI images were processed through an open-source segmentation pipeline, "BIBSNet". Hippocampal segmentations were further subdivided into head, body, and tail subregions manually for 426 visits, which were then used to train models to automatically segment the rest of the hippocampal subregions. Generalized additive mixed models (GAMMs) were then used to measure trajectories of development across the thalamus, amygdala, and subregions of the hippocampus. Trajectories of volume growth differed across regions and even across subregions within the hippocampus, with the head of the hippocampus showing steep growth that plateaued months later than the body or tail of the hippocampus. 58 participants from the BCP returned for a school-aged follow-up, including two episodic memory tasks. In the right head of the hippocampus, residuals from the GAMM-predicted volume positively predicted later performance on an episodic memory task. Using GAMMs that accounted for total brain volume, the right thalamus residuals also predicted memory performance. Total sleep duration at the school-aged visit accounted for variance above and beyond these brain volume correlations. 56 preterm-born and 55 age-matched 5-year-old full-term participants were recruited and performed the same episodic memory tasks as the BCP follow-up participants. No deficits were found in episodic memory performance for participants born preterm. An interaction was found between gestational age and sleep disturbance scores such that sleep disturbance only correlated with episodic memory performance in participants born preterm. Altogether, these results build on prior literature that suggests both the timing of growth and relationships with aspects of episodic memory performance are region and subregion specific. The relations between sleep and memory performance provide evidence for the important role of sleep in the relationship between brain networks and early episodic memory development. These results provide important information into the brain development underlying the development of episodic memory and how early trajectories of memory development might be influenced by insults to early brain development.
■590 ▼aSchool code: 0130.
■650 4▼aDevelopmental psychology
■650 4▼aNeurosciences
■650 4▼aCognitive psychology
■653 ▼aBrain networks
■653 ▼aMRI images
■653 ▼aInfantile amnesia
■653 ▼aBrain development
■690 ▼a0620
■690 ▼a0317
■690 ▼a0633
■71020▼aUniversity of Minnesota▼bDevelopmental Psychology.
■7730 ▼tDissertations Abstracts International▼g87-06B.
■790 ▼a0130
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17357955▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.


