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The Structural Development of Early Memory-Related Brain Networks and Their Relationship With Episodic Memory Performance: Implications for Perinatal Brain Insults
The Structural Development of Early Memory-Related Brain Networks and Their Relationship W...
The Structural Development of Early Memory-Related Brain Networks and Their Relationship With Episodic Memory Performance: Implications for Perinatal Brain Insults

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자료유형  
 학위논문 서양
최종처리일시  
20260202103623
ISBN  
9798270250010
DDC  
136
저자명  
Stoyell, Sally M.
서명/저자  
The Structural Development of Early Memory-Related Brain Networks and Their Relationship With Episodic Memory Performance: Implications for Perinatal Brain Insults
발행사항  
[Sl] : University of Minnesota, 2025
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2025
형태사항  
120 p
주기사항  
Source: Dissertations Abstracts International, Volume: 87-06, Section: B.
주기사항  
Advisor: Thomas, Kathleen;Elison, Jed.
학위논문주기  
Thesis (Ph.D.)--University of Minnesota, 2025.
초록/해제  
요약Little is known about the brain networks that support episodic memory development in the first years of life. Literature suggests that protracted growth of the hippocampus may relate to the susceptibility of regions in memory brain networks when exposed to perinatal insults, as well as to phenomenon such as infantile amnesia. Yet the role of structural development in these memory brain networks in episodic memory is not yet fully elucidated. In this dissertation, two studies were utilized to analyze how brain development and episodic memory are interrelated and how this development might be altered when infants are born prematurely. In 835 visits from 0-4 years of age across 322 participants in the Baby Connectome Project, MRI images were processed through an open-source segmentation pipeline, "BIBSNet". Hippocampal segmentations were further subdivided into head, body, and tail subregions manually for 426 visits, which were then used to train models to automatically segment the rest of the hippocampal subregions. Generalized additive mixed models (GAMMs) were then used to measure trajectories of development across the thalamus, amygdala, and subregions of the hippocampus. Trajectories of volume growth differed across regions and even across subregions within the hippocampus, with the head of the hippocampus showing steep growth that plateaued months later than the body or tail of the hippocampus. 58 participants from the BCP returned for a school-aged follow-up, including two episodic memory tasks. In the right head of the hippocampus, residuals from the GAMM-predicted volume positively predicted later performance on an episodic memory task. Using GAMMs that accounted for total brain volume, the right thalamus residuals also predicted memory performance. Total sleep duration at the school-aged visit accounted for variance above and beyond these brain volume correlations. 56 preterm-born and 55 age-matched 5-year-old full-term participants were recruited and performed the same episodic memory tasks as the BCP follow-up participants. No deficits were found in episodic memory performance for participants born preterm. An interaction was found between gestational age and sleep disturbance scores such that sleep disturbance only correlated with episodic memory performance in participants born preterm. Altogether, these results build on prior literature that suggests both the timing of growth and relationships with aspects of episodic memory performance are region and subregion specific. The relations between sleep and memory performance provide evidence for the important role of sleep in the relationship between brain networks and early episodic memory development. These results provide important information into the brain development underlying the development of episodic memory and how early trajectories of memory development might be influenced by insults to early brain development.
일반주제명  
Developmental psychology
일반주제명  
Neurosciences
일반주제명  
Cognitive psychology
키워드  
Brain networks
키워드  
MRI images
키워드  
Infantile amnesia
키워드  
Brain development
기타저자  
University of Minnesota Developmental Psychology
기본자료저록  
Dissertations Abstracts International. 87-06B.
전자적 위치 및 접속  
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MARC

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■035    ▼a(MiAaPQ)AAI32045825
■040    ▼aMiAaPQ▼cMiAaPQ
■0820  ▼a136
■1001  ▼aStoyell,  Sally  M.
■24510▼aThe  Structural  Development  of  Early  Memory-Related  Brain  Networks  and  Their  Relationship  With  Episodic  Memory  Performance:  Implications  for  Perinatal  Brain  Insults
■260    ▼a[Sl]▼bUniversity  of  Minnesota▼c2025
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2025
■300    ▼a120  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  87-06,  Section:  B.
■500    ▼aAdvisor:  Thomas,  Kathleen;Elison,  Jed.
■5021  ▼aThesis  (Ph.D.)--University  of  Minnesota,  2025.
■520    ▼aLittle  is  known  about  the  brain  networks  that  support  episodic  memory  development  in  the  first  years  of  life.  Literature  suggests  that  protracted  growth  of  the  hippocampus  may  relate  to  the  susceptibility  of  regions  in  memory  brain  networks  when  exposed  to  perinatal  insults,  as  well  as  to  phenomenon  such  as  infantile  amnesia.  Yet  the  role  of  structural  development  in  these  memory  brain  networks  in  episodic  memory  is  not  yet  fully  elucidated.  In  this  dissertation,  two  studies  were  utilized  to  analyze  how  brain  development  and  episodic  memory  are  interrelated  and  how  this  development  might  be  altered  when  infants  are  born  prematurely.  In  835  visits  from  0-4  years  of  age  across  322  participants  in  the  Baby  Connectome  Project,  MRI  images  were  processed  through  an  open-source  segmentation  pipeline,  "BIBSNet".  Hippocampal  segmentations  were  further  subdivided  into  head,  body,  and  tail  subregions  manually  for  426  visits,  which  were  then  used  to  train  models  to  automatically  segment  the  rest  of  the  hippocampal  subregions.  Generalized  additive  mixed  models  (GAMMs)  were  then  used  to  measure  trajectories  of  development  across  the  thalamus,  amygdala,  and  subregions  of  the  hippocampus.  Trajectories  of  volume  growth  differed  across  regions  and  even  across  subregions  within  the  hippocampus,  with  the  head  of  the  hippocampus  showing  steep  growth  that  plateaued  months  later  than  the  body  or  tail  of  the  hippocampus.  58  participants  from  the  BCP  returned  for  a  school-aged  follow-up,  including  two  episodic  memory  tasks.  In  the  right  head  of  the  hippocampus,  residuals  from  the  GAMM-predicted  volume  positively  predicted  later  performance  on  an  episodic  memory  task.  Using  GAMMs  that  accounted  for  total  brain  volume,  the  right  thalamus  residuals  also  predicted  memory  performance.  Total  sleep  duration  at  the  school-aged  visit  accounted  for  variance  above  and  beyond  these  brain  volume  correlations.  56  preterm-born  and  55  age-matched  5-year-old  full-term  participants  were  recruited  and  performed  the  same  episodic  memory  tasks  as  the  BCP  follow-up  participants.  No  deficits  were  found  in  episodic  memory  performance  for  participants  born  preterm.  An  interaction  was  found  between  gestational  age  and  sleep  disturbance  scores  such  that  sleep  disturbance  only  correlated  with  episodic  memory  performance  in  participants  born  preterm.  Altogether,  these  results  build  on  prior  literature  that  suggests  both  the  timing  of  growth  and  relationships  with  aspects  of  episodic  memory  performance  are  region  and  subregion  specific.  The  relations  between  sleep  and  memory  performance  provide  evidence  for  the  important  role  of  sleep  in  the  relationship  between  brain  networks  and  early  episodic  memory  development.  These  results  provide  important  information  into  the  brain  development  underlying  the  development  of  episodic  memory  and  how  early  trajectories  of  memory  development  might  be  influenced  by  insults  to  early  brain  development.
■590    ▼aSchool  code:  0130.
■650  4▼aDevelopmental  psychology
■650  4▼aNeurosciences
■650  4▼aCognitive  psychology
■653    ▼aBrain  networks
■653    ▼aMRI  images
■653    ▼aInfantile  amnesia
■653    ▼aBrain  development
■690    ▼a0620
■690    ▼a0317
■690    ▼a0633
■71020▼aUniversity  of  Minnesota▼bDevelopmental  Psychology.
■7730  ▼tDissertations  Abstracts  International▼g87-06B.
■790    ▼a0130
■791    ▼aPh.D.
■792    ▼a2025
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17357955▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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