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Investigating Cochlear Responses Using a Physiologically Based Model
Investigating Cochlear Responses Using a Physiologically Based Model
Investigating Cochlear Responses Using a Physiologically Based Model

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자료유형  
 학위논문 서양
최종처리일시  
20260202105526
ISBN  
9798263344016
DDC  
500
저자명  
Samaras, Georgios.
서명/저자  
Investigating Cochlear Responses Using a Physiologically Based Model
발행사항  
[Sl] : Georgia Institute of Technology, 2025
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2025
형태사항  
123 p
주기사항  
Source: Dissertations Abstracts International, Volume: 87-05, Section: B.
주기사항  
Advisor: Meaud, Julien.
학위논문주기  
Thesis (Ph.D.)--Georgia Institute of Technology, 2025.
초록/해제  
요약The mammalian cochlea bestows humans and other mammals with remarkable hearing ability over a wide range of frequencies and stimulus levels. This is achieved in part through an active feedback mechanism, termed the cochlear amplifier, which boosts the cochlear response to low-level stimuli. Cutting edge experiments over the last few decades have probed mechanical and electrical responses inside the cochlea with unprecedented detail. These studies have shown that the organ of Corti, which is a strip of cellular and structural components in the cochlea that mediates sound transduction to nerve signals, exhibits complex relative motions rather than rigid body motion as previously thought. In turn, these new findings have challenged traditional theories about how the cochlear amplifier, which is facilitated by outer hair cells in the organ of Corti, functions. In this dissertation, a computational model of the mammalian cochlea is implemented with a reformulated structural model of the organ of Corti that improves the feasibility of changes to model assumptions. The model is used to show that compliance of some structural elements of the organ of Corti leads to complex motion between organ of Corti structures. Furthermore, the Deiters' cells in the organ of Corti are made much more compliant than the basilar membrane, based on new evidence. The influence of this more realistic compliance on power transfer to cochlear traveling waves is evaluated. The results of this study challenge the traditional theory of how outer hair cells amplify cochlear responses, which is that they apply a force directly on the basilar membrane through rigid Deiters' cells, and a new theory of how they may do so is presented. By expanding model assumptions based on experimental evidence, and characterizing power delivery of the cochlear amplifier, the research in this thesis expands understanding of cochlear mechanics.
일반주제명  
Kinematics
일반주제명  
Tomography
일반주제명  
Fluid-structure interaction
일반주제명  
Mechanics
일반주제명  
Eardrum
일반주제명  
Electricity generation
일반주제명  
Hearing protection
일반주제명  
Electric power
일반주제명  
Audiology
일반주제명  
Fluid mechanics
일반주제명  
Medical imaging
기타저자  
Georgia Institute of Technology.
기본자료저록  
Dissertations Abstracts International. 87-05B.
전자적 위치 및 접속  
로그인 후 원문을 볼 수 있습니다.

MARC

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■0820  ▼a500
■1001  ▼aSamaras,  Georgios.
■24510▼aInvestigating  Cochlear  Responses  Using  a  Physiologically  Based  Model
■260    ▼a[Sl]▼bGeorgia  Institute  of  Technology▼c2025
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2025
■300    ▼a123  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  87-05,  Section:  B.
■500    ▼aAdvisor:  Meaud,  Julien.
■5021  ▼aThesis  (Ph.D.)--Georgia  Institute  of  Technology,  2025.
■520    ▼aThe  mammalian  cochlea  bestows  humans  and  other  mammals  with  remarkable  hearing  ability  over  a  wide  range  of  frequencies  and  stimulus  levels.  This  is  achieved  in  part  through  an  active  feedback  mechanism,  termed  the  cochlear  amplifier,  which  boosts  the  cochlear  response  to  low-level  stimuli.  Cutting  edge  experiments  over  the  last  few  decades  have  probed  mechanical  and  electrical  responses  inside  the  cochlea  with  unprecedented  detail.  These  studies  have  shown  that  the  organ  of  Corti,  which  is  a  strip  of  cellular  and  structural  components  in  the  cochlea  that  mediates  sound  transduction  to  nerve  signals,  exhibits  complex  relative  motions  rather  than  rigid  body  motion  as  previously  thought.  In  turn,  these  new  findings  have  challenged  traditional  theories  about  how  the  cochlear  amplifier,  which  is  facilitated  by  outer  hair  cells  in  the  organ  of  Corti,  functions.  In  this  dissertation,  a  computational  model  of  the  mammalian  cochlea  is  implemented  with  a  reformulated  structural  model  of  the  organ  of  Corti  that  improves  the  feasibility  of  changes  to  model  assumptions.  The  model  is  used  to  show  that  compliance  of  some  structural  elements  of  the  organ  of  Corti  leads  to  complex  motion  between  organ  of  Corti  structures.  Furthermore,  the  Deiters'  cells  in  the  organ  of  Corti  are  made  much  more  compliant  than  the  basilar  membrane,  based  on  new  evidence.  The  influence  of  this  more  realistic  compliance  on  power  transfer  to  cochlear  traveling  waves  is  evaluated.  The  results  of  this  study  challenge  the  traditional  theory  of  how  outer  hair  cells  amplify  cochlear  responses,  which  is  that  they  apply  a  force  directly  on  the  basilar  membrane  through  rigid  Deiters'  cells,  and  a  new  theory  of  how  they  may  do  so  is  presented.  By  expanding  model  assumptions  based  on  experimental  evidence,  and  characterizing  power  delivery  of  the  cochlear  amplifier,  the  research  in  this  thesis  expands  understanding  of  cochlear  mechanics.
■590    ▼aSchool  code:  0078.
■650  4▼aKinematics
■650  4▼aTomography
■650  4▼aFluid-structure  interaction
■650  4▼aMechanics
■650  4▼aEardrum
■650  4▼aElectricity  generation
■650  4▼aHearing  protection
■650  4▼aElectric  power
■650  4▼aAudiology
■650  4▼aFluid  mechanics
■650  4▼aMedical  imaging
■690    ▼a0346
■690    ▼a0300
■690    ▼a0204
■690    ▼a0574
■71020▼aGeorgia  Institute  of  Technology.
■7730  ▼tDissertations  Abstracts  International▼g87-05B.
■790    ▼a0078
■791    ▼aPh.D.
■792    ▼a2025
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17360436▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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