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Through the Recurrent Neural Network Looking Glass: Structure-Function Relationships in Cortical Circuits for Predictive Coding
Through the Recurrent Neural Network Looking Glass: Structure-Function Relationships in Co...
Through the Recurrent Neural Network Looking Glass: Structure-Function Relationships in Cortical Circuits for Predictive Coding

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자료유형  
 학위논문 서양
최종처리일시  
20260202105531
ISBN  
9798263344221
DDC  
006
저자명  
Balwani, Aishwarya.
서명/저자  
Through the Recurrent Neural Network Looking Glass: Structure-Function Relationships in Cortical Circuits for Predictive Coding
발행사항  
[Sl] : Georgia Institute of Technology, 2025
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2025
형태사항  
190 p
주기사항  
Source: Dissertations Abstracts International, Volume: 87-05, Section: B.
주기사항  
Advisor: Choi, Hannah;Rozell, Christopher.
학위논문주기  
Thesis (Ph.D.)--Georgia Institute of Technology, 2025.
초록/해제  
요약The elucidation of structure-function relationships in neural circuits forms the cornerstone of theoretical and computational neuroscience. It lays the foundation for our understanding of information representation and processing in the brain, influencing normative theories of neural dynamics, cognition, and behaviour. It also sheds light on the mechanistic properties of these circuits, thereby guiding research in systems neuroscience, artificial intelligence, and machine learning. However, despite decades of neuroscientific inquiry and technological advancements, our grasp on how neural architecture shapes its computations remains incomplete. This limitation is particularly evident in our understanding of the cortex, where its intricate laminar structure is arranged into the recurring neuroanatomical motif known as the canonical cortical microcircuit. While we have extensive knowledge of the structural scaffolding itself, we lack a comprehensive understanding of how this architecture supports its sophisticated information processing. Specifically, the precise mechanisms by which the canonical microcircuit and its inter-areal connections facilitate predictive coding, a theoretical framework positing that the cortex implements hierarchical, predictive computations for efficient perception and inference, remains elusive.Unfortunately, in-vivo efforts to experimentally test the underlying mechanisms of predictive coding still face enormous challenges. Furthermore, even as recent experimental advances have begun to yield interesting multi-regional neuronal recordings, our ability to reliably interpret these datasets at scale remains limited. In-silico approaches, therefore, present an encouraging avenue to address these shortcomings. Specifically, recurrent neural networks (RNNs) offer a powerful framework to investigate hypotheses about hierarchical predictive coding that are currently challenging to test in-vivo, owing to their ability to effectively exploit temporal dependencies typical of natural stimuli, learn distributed representations, and model complex, multi-regional neuronal dynamics.Hence, this thesis employs RNNs as models of cortical circuits, illustrating how they can be leveraged to study the inherent architectural biases of the canonical cortical microcircuit and their functional implications, in light of the predictive coding hypothesis. Specifically, it i) Establishes a computational framework using RNNs and representational analyses to study the effects of biologically-motivated inter-areal laminar connections on the computational roles of different neuronal populations in the microcircuit across hierarchically-related areas, ii) Demonstrates how feedback connections combined with time-delays provide an inductive bias for differentiating expected and unexpected inputs, and iii) Studies the effects of including a predictive coding-based training strategy on the representational geometry of neuronal populations receiving inter-areal feedback. Furthermore, this dissertation also develops tools that address limitations concerning the anatomical fidelity of conventional RNN architecture and training, thereby improving their overall biological plausibility and potential for modelling real neural circuits. More concretely, the key contributions include mathematically-grounded methods with performance guarantees for i) Training RNNs that respect Dale's law, and ii) Pruning RNN weights to enforce highly sparse, structured connectivity patterns amongst different neuronal populations. Finally, applying these methods to analyze multi-regional interactions in 2-photon calcium imaging data from mice performing a predictive visual task corroborates experimental evidence in support of the predictive coding hypothesis, showing the utility of the proposed methods and overall approach.The contributions of this thesis therefore provide a robust, computational framework for modelling and interpreting complex, multi-regional neuronal data, ultimately paving the way for deeper insights into how the structural properties of cortical circuits support sophisticated information processing and intelligent behavior.
일반주제명  
Deep learning
일반주제명  
Back propagation
일반주제명  
Neural networks
일반주제명  
Neurosciences
일반주제명  
Information processing
기타저자  
Georgia Institute of Technology.
기본자료저록  
Dissertations Abstracts International. 87-05B.
전자적 위치 및 접속  
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■1001  ▼aBalwani,  Aishwarya.
■24510▼aThrough  the  Recurrent  Neural  Network  Looking  Glass:  Structure-Function  Relationships  in  Cortical  Circuits  for  Predictive  Coding
■260    ▼a[Sl]▼bGeorgia  Institute  of  Technology▼c2025
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2025
■300    ▼a190  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  87-05,  Section:  B.
■500    ▼aAdvisor:  Choi,  Hannah;Rozell,  Christopher.
■5021  ▼aThesis  (Ph.D.)--Georgia  Institute  of  Technology,  2025.
■520    ▼aThe  elucidation  of  structure-function  relationships  in  neural  circuits  forms  the  cornerstone  of  theoretical  and  computational  neuroscience.  It  lays  the  foundation  for  our  understanding  of  information  representation  and  processing  in  the  brain,  influencing  normative  theories  of  neural  dynamics,  cognition,  and  behaviour.  It  also  sheds  light  on  the  mechanistic  properties  of  these  circuits,  thereby  guiding  research  in  systems  neuroscience,  artificial  intelligence,  and  machine  learning.  However,  despite  decades  of  neuroscientific  inquiry  and  technological  advancements,  our  grasp  on  how  neural  architecture  shapes  its  computations  remains  incomplete.  This  limitation  is  particularly  evident  in  our  understanding  of  the  cortex,  where  its  intricate  laminar  structure  is  arranged  into  the  recurring  neuroanatomical  motif  known  as  the  canonical  cortical  microcircuit.  While  we  have  extensive  knowledge  of  the  structural  scaffolding  itself,  we  lack  a  comprehensive  understanding  of  how  this  architecture  supports  its  sophisticated  information  processing.  Specifically,  the  precise  mechanisms  by  which  the  canonical  microcircuit  and  its  inter-areal  connections  facilitate  predictive  coding,  a  theoretical  framework  positing  that  the  cortex  implements  hierarchical,  predictive  computations  for  efficient  perception  and  inference,  remains  elusive.Unfortunately,  in-vivo  efforts  to  experimentally  test  the  underlying  mechanisms  of  predictive  coding  still  face  enormous  challenges.  Furthermore,  even  as  recent  experimental  advances  have  begun  to  yield  interesting  multi-regional  neuronal  recordings,  our  ability  to  reliably  interpret  these  datasets  at  scale  remains  limited.  In-silico  approaches,  therefore,  present  an  encouraging  avenue  to  address  these  shortcomings.  Specifically,  recurrent  neural  networks  (RNNs)  offer  a  powerful  framework  to  investigate  hypotheses  about  hierarchical  predictive  coding  that  are  currently  challenging  to  test  in-vivo,  owing  to  their  ability  to  effectively  exploit  temporal  dependencies  typical  of  natural  stimuli,  learn  distributed  representations,  and  model  complex,  multi-regional  neuronal  dynamics.Hence,  this  thesis  employs  RNNs  as  models  of  cortical  circuits,  illustrating  how  they  can  be  leveraged  to  study  the  inherent  architectural  biases  of  the  canonical  cortical  microcircuit  and  their  functional  implications,  in  light  of  the  predictive  coding  hypothesis.  Specifically,  it  i)  Establishes  a  computational  framework  using  RNNs  and  representational  analyses  to  study  the  effects  of  biologically-motivated  inter-areal  laminar  connections  on  the  computational  roles  of  different  neuronal  populations  in  the  microcircuit  across  hierarchically-related  areas,  ii)  Demonstrates  how  feedback  connections  combined  with  time-delays  provide  an  inductive  bias  for  differentiating  expected  and  unexpected  inputs,  and  iii)  Studies  the  effects  of  including  a  predictive  coding-based  training  strategy  on  the  representational  geometry  of  neuronal  populations  receiving  inter-areal  feedback.  Furthermore,  this  dissertation  also  develops  tools  that  address  limitations  concerning  the  anatomical  fidelity  of  conventional  RNN  architecture  and  training,  thereby  improving  their  overall  biological  plausibility  and  potential  for  modelling  real  neural  circuits.  More  concretely,  the  key  contributions  include  mathematically-grounded  methods  with  performance  guarantees  for  i)  Training  RNNs  that  respect  Dale's  law,  and  ii)  Pruning  RNN  weights  to  enforce  highly  sparse,  structured  connectivity  patterns  amongst  different  neuronal  populations.  Finally,  applying  these  methods  to  analyze  multi-regional  interactions  in  2-photon  calcium  imaging  data  from  mice  performing  a  predictive  visual  task  corroborates  experimental  evidence  in  support  of  the  predictive  coding  hypothesis,  showing  the  utility  of  the  proposed  methods  and  overall  approach.The  contributions  of  this  thesis  therefore  provide  a  robust,  computational  framework  for  modelling  and  interpreting  complex,  multi-regional  neuronal  data,  ultimately  paving  the  way  for  deeper  insights  into  how  the  structural  properties  of  cortical  circuits  support  sophisticated  information  processing  and  intelligent  behavior.
■590    ▼aSchool  code:  0078.
■650  4▼aDeep  learning
■650  4▼aBack  propagation
■650  4▼aNeural  networks
■650  4▼aNeurosciences
■650  4▼aInformation  processing
■690    ▼a0800
■690    ▼a0317
■71020▼aGeorgia  Institute  of  Technology.
■7730  ▼tDissertations  Abstracts  International▼g87-05B.
■790    ▼a0078
■791    ▼aPh.D.
■792    ▼a2025
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17360467▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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