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Mechanisms Linking Pre-mRNA Splicing to Longevity in C. elegans
Mechanisms Linking Pre-mRNA Splicing to Longevity in C. elegans
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202103205
- ISBN
- 9798280712959
- DDC
- 574
- 서명/저자
- Mechanisms Linking Pre-mRNA Splicing to Longevity in C. elegans
- 발행사항
- [Sl] : Harvard University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 191 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
- 주기사항
- Advisor: Mair, William B.
- 학위논문주기
- Thesis (Ph.D.)--Harvard University, 2025.
- 초록/해제
- 요약Geroscience aims to target the fundamental biology of aging to address the increasing prevalence of age-related diseases. However, a comprehensive understanding of molecular mechanisms underlying longevity interventions and inter-individual variability remains elusive. Prior work in C. elegans determined a critical role of splicing factors SFA-1 and REPO-1 as pathway-specific modulators of longevity, and postulated lipid metabolism, particularly through POD-2, as a downstream effector mechanism. My PhD thesis characterized pre-mRNA splicing and lipidomic changes associated with REPO-1 loss, and determined that POD-2 phenocopies REPO-1 in the regulation of lipid deposits and lifespan extension by dietary restriction, reduced TORC1 and mutant ETC. This work also defined the spatial and temporal effects of REPO-1 loss. These data elucidate molecular mechanisms of responses to longevity interventions. Additionally, my dissertation work demonstrated that differences in Oleic acid concentration underly variation in lifespan expectancy using the ret-1 splicing reporter. This work exemplifies the utility of multi-staged assessment of lifespan variation, thereby significantly contributing to the advancement of precision Geroscience. Altogether, my dissertation substantiates the role of pre-mRNA splicing in both the regulation of response to longevity interventions and the prediction of lifespan expectancy.
- 일반주제명
- Molecular biology
- 일반주제명
- Biology
- 일반주제명
- Biochemistry
- 일반주제명
- Genetics
- 키워드
- Heterogeneity
- 키워드
- Longevity
- 키워드
- Splicing factors
- 기타저자
- Harvard University Biological Sciences in Public Health
- 기본자료저록
- Dissertations Abstracts International. 86-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798280712959
■035 ▼a(MiAaPQ)AAI31999813
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aPerez Matos, Maria Camila.▼0(orcid)0000-0002-2841-9810
■24510▼aMechanisms Linking Pre-mRNA Splicing to Longevity in C. elegans
■260 ▼a[Sl]▼bHarvard University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a191 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-12, Section: B.
■500 ▼aAdvisor: Mair, William B.
■5021 ▼aThesis (Ph.D.)--Harvard University, 2025.
■520 ▼aGeroscience aims to target the fundamental biology of aging to address the increasing prevalence of age-related diseases. However, a comprehensive understanding of molecular mechanisms underlying longevity interventions and inter-individual variability remains elusive. Prior work in C. elegans determined a critical role of splicing factors SFA-1 and REPO-1 as pathway-specific modulators of longevity, and postulated lipid metabolism, particularly through POD-2, as a downstream effector mechanism. My PhD thesis characterized pre-mRNA splicing and lipidomic changes associated with REPO-1 loss, and determined that POD-2 phenocopies REPO-1 in the regulation of lipid deposits and lifespan extension by dietary restriction, reduced TORC1 and mutant ETC. This work also defined the spatial and temporal effects of REPO-1 loss. These data elucidate molecular mechanisms of responses to longevity interventions. Additionally, my dissertation work demonstrated that differences in Oleic acid concentration underly variation in lifespan expectancy using the ret-1 splicing reporter. This work exemplifies the utility of multi-staged assessment of lifespan variation, thereby significantly contributing to the advancement of precision Geroscience. Altogether, my dissertation substantiates the role of pre-mRNA splicing in both the regulation of response to longevity interventions and the prediction of lifespan expectancy.
■590 ▼aSchool code: 0084.
■650 4▼aMolecular biology
■650 4▼aBiology
■650 4▼aBiochemistry
■650 4▼aGenetics
■653 ▼aHeterogeneity
■653 ▼aLongevity
■653 ▼aPre-mRNA splicing
■653 ▼aSplicing factors
■690 ▼a0307
■690 ▼a0487
■690 ▼a0306
■690 ▼a0369
■71020▼aHarvard University▼bBiological Sciences in Public Health.
■7730 ▼tDissertations Abstracts International▼g86-12B.
■790 ▼a0084
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17357305▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
