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Early Caregiving Adversity and Internalizing Symptoms in Middle Childhood to Adolescence: Gut Microbiome and Inflammatory Mechanisms
Early Caregiving Adversity and Internalizing Symptoms in Middle Childhood to Adolescence: Gut Microbiome and Inflammatory Mechanisms
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202104640
- ISBN
- 9798280748385
- DDC
- 150
- 서명/저자
- Early Caregiving Adversity and Internalizing Symptoms in Middle Childhood to Adolescence: Gut Microbiome and Inflammatory Mechanisms
- 발행사항
- [Sl] : University of California, Los Angeles, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 179 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
- 주기사항
- Advisor: Callaghan, Bridget.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Los Angeles, 2025.
- 초록/해제
- 요약Caregiving-related early life adversity (crEA) is associated with increased risk for internalizing psychopathology (e.g., anxiety and depression symptoms) across the lifespan. While much research has focused on the brain as a mechanism underlying crEA impacts on internalizing symptoms, two peripheral biological systems - the gut microbiome and immune system - may also play important roles. However, further research is needed to understand their relations to crEA and contributions to internalizing symptoms in middle childhood to adolescence, a heightened risk period for internalizing symptom onset. Across three studies, this dissertation examined the independent and joint associations between the gut microbiome and immune system with internalizing symptoms and crEA in a longitudinal cohort with varied exposure to crEA. Studies integrated measures of gut microbiome and immune system function with specific biological and developmental relevance for this age group, multimethod analyses including hypothesis testing and multivariate machine learning approaches, and multi-informant assessments of internalizing symptoms and fatigue, a transdiagnostic symptom domain that may be particularly relevant to the gut-microbiome-immune axis. Study 1 found that crEA was associated with lower potential for a microbiome functional pathway that produces acetate in boys, and that higher potential for another acetate-producing pathway (not tied to crEA) was related to more self-reported internalizing and fatigue symptoms at the subsequent time point. Study 2 found no associations with crEA, but showed that inflammatory gene expression was positively associated with concurrent self-reported fatigue symptoms and caregiver-reported fatigue symptoms for older children. Lastly, Study 3 derived two "inflammatory-microbiome" signatures, or collections of microbiome pathways that covaried most strongly with inflammatory gene expression. One of the signatures was associated with higher caregiver-reported and self-reported internalizing and fatigue symptoms. Taken together, the studies highlight the need to further examine potential moderators (e.g., diet, current stress, brain function, biological sex) in the associations between crEA and peripheral biology. They also demonstrate consistent links between nodes of the gut-microbiome-immune axis and symptoms, suggesting the gut microbiome and inflammatory biology play important roles in childhood health and generating potential future directions for novel interventions.
- 일반주제명
- Psychology
- 일반주제명
- Psychobiology
- 일반주제명
- Mental health
- 키워드
- Children
- 키워드
- Inflammation
- 키워드
- Microbiome
- 기타저자
- University of California, Los Angeles Psychology 0780
- 기본자료저록
- Dissertations Abstracts International. 86-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a150
■1001 ▼aNoonan Querdasi, Francesca Ruth.
■24510▼aEarly Caregiving Adversity and Internalizing Symptoms in Middle Childhood to Adolescence: Gut Microbiome and Inflammatory Mechanisms
■260 ▼a[Sl]▼bUniversity of California, Los Angeles▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a179 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-12, Section: B.
■500 ▼aAdvisor: Callaghan, Bridget.
■5021 ▼aThesis (Ph.D.)--University of California, Los Angeles, 2025.
■520 ▼aCaregiving-related early life adversity (crEA) is associated with increased risk for internalizing psychopathology (e.g., anxiety and depression symptoms) across the lifespan. While much research has focused on the brain as a mechanism underlying crEA impacts on internalizing symptoms, two peripheral biological systems - the gut microbiome and immune system - may also play important roles. However, further research is needed to understand their relations to crEA and contributions to internalizing symptoms in middle childhood to adolescence, a heightened risk period for internalizing symptom onset. Across three studies, this dissertation examined the independent and joint associations between the gut microbiome and immune system with internalizing symptoms and crEA in a longitudinal cohort with varied exposure to crEA. Studies integrated measures of gut microbiome and immune system function with specific biological and developmental relevance for this age group, multimethod analyses including hypothesis testing and multivariate machine learning approaches, and multi-informant assessments of internalizing symptoms and fatigue, a transdiagnostic symptom domain that may be particularly relevant to the gut-microbiome-immune axis. Study 1 found that crEA was associated with lower potential for a microbiome functional pathway that produces acetate in boys, and that higher potential for another acetate-producing pathway (not tied to crEA) was related to more self-reported internalizing and fatigue symptoms at the subsequent time point. Study 2 found no associations with crEA, but showed that inflammatory gene expression was positively associated with concurrent self-reported fatigue symptoms and caregiver-reported fatigue symptoms for older children. Lastly, Study 3 derived two "inflammatory-microbiome" signatures, or collections of microbiome pathways that covaried most strongly with inflammatory gene expression. One of the signatures was associated with higher caregiver-reported and self-reported internalizing and fatigue symptoms. Taken together, the studies highlight the need to further examine potential moderators (e.g., diet, current stress, brain function, biological sex) in the associations between crEA and peripheral biology. They also demonstrate consistent links between nodes of the gut-microbiome-immune axis and symptoms, suggesting the gut microbiome and inflammatory biology play important roles in childhood health and generating potential future directions for novel interventions.
■590 ▼aSchool code: 0031.
■650 4▼aPsychology
■650 4▼aPsychobiology
■650 4▼aMental health
■653 ▼aChildren
■653 ▼aEarly life adversity
■653 ▼aInflammation
■653 ▼aMicrobiome
■653 ▼aDepression symptoms
■690 ▼a0621
■690 ▼a0349
■690 ▼a0347
■71020▼aUniversity of California, Los Angeles▼bPsychology 0780.
■7730 ▼tDissertations Abstracts International▼g86-12B.
■790 ▼a0031
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17358302▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
