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Advancing Pharmaceutical Chemistry: Innovative Approaches in Photoredox Catalysis and Late-Stage Functionalization
Advancing Pharmaceutical Chemistry: Innovative Approaches in Photoredox Catalysis and Late-Stage Functionalization
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105219
- ISBN
- 9798291566008
- DDC
- 540
- 서명/저자
- Advancing Pharmaceutical Chemistry: Innovative Approaches in Photoredox Catalysis and Late-Stage Functionalization
- 발행사항
- [Sl] : University of Michigan, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 433 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-02, Section: B.
- 주기사항
- Advisor: Soellner, Matt.
- 학위논문주기
- Thesis (Ph.D.)--University of Michigan, 2025.
- 초록/해제
- 요약This dissertation encompasses three distinct projects spanning from early-stage methodology in photoredox catalysis to late-stage functionalization, complex-molecule synthesis, and biological testing. Chapter 2 presents a novel methodology to synthesize 2-azanorbornane scaffolds via visible-light photoredox catalysis. This approach provides a versatile platform constructing saturated, nitrogen heterocycles, which have seen a significant rise in importance over the years. Moreover, photochemical methodologies enable unique and challenging bond formations in a mild manner, expanding the toolkit for modern synthetic chemistry. In Chapter 3, I describe our efforts toward the late-stage chlorination of kinase inhibitors and their subsequent biological evaluation. We demonstrated that regioselective chlorination of kinase inhibitors can influence the selectivity and binding affinity of these compounds in varying ways. The goal of this project was to investigate how the incorporation of chlorine affects selectivity, thereby informing future design strategies. Chapter 4 focuses on a modular, two-step process for synthesizing pyrazolopyrimidines. This project provides a flexible platform to enable iterative compound design and rapid library generation. This methodology facilitates efficient exploration of new chemical space and biological impacts. Collectively, these studies have clear and innovative applications in both the discovery and process chemistry realms. I envision that these projects will not only serve as the groundwork for future methodologies and syntheses but also inspire advancements in the design of novel molecules.
- 일반주제명
- Chemistry
- 일반주제명
- Pharmaceutical sciences
- 일반주제명
- Biochemistry
- 일반주제명
- Organic chemistry
- 키워드
- 2-Azanorbornane
- 기타저자
- University of Michigan Chemistry
- 기본자료저록
- Dissertations Abstracts International. 87-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■007cr#unu||||||||
■020 ▼a9798291566008
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■035 ▼a(MiAaPQ)umichrackham006494
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a540
■1001 ▼aTharp, Annika Elyse.
■24510▼aAdvancing Pharmaceutical Chemistry: Innovative Approaches in Photoredox Catalysis and Late-Stage Functionalization
■260 ▼a[Sl]▼bUniversity of Michigan▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a433 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-02, Section: B.
■500 ▼aAdvisor: Soellner, Matt.
■5021 ▼aThesis (Ph.D.)--University of Michigan, 2025.
■520 ▼aThis dissertation encompasses three distinct projects spanning from early-stage methodology in photoredox catalysis to late-stage functionalization, complex-molecule synthesis, and biological testing. Chapter 2 presents a novel methodology to synthesize 2-azanorbornane scaffolds via visible-light photoredox catalysis. This approach provides a versatile platform constructing saturated, nitrogen heterocycles, which have seen a significant rise in importance over the years. Moreover, photochemical methodologies enable unique and challenging bond formations in a mild manner, expanding the toolkit for modern synthetic chemistry. In Chapter 3, I describe our efforts toward the late-stage chlorination of kinase inhibitors and their subsequent biological evaluation. We demonstrated that regioselective chlorination of kinase inhibitors can influence the selectivity and binding affinity of these compounds in varying ways. The goal of this project was to investigate how the incorporation of chlorine affects selectivity, thereby informing future design strategies. Chapter 4 focuses on a modular, two-step process for synthesizing pyrazolopyrimidines. This project provides a flexible platform to enable iterative compound design and rapid library generation. This methodology facilitates efficient exploration of new chemical space and biological impacts. Collectively, these studies have clear and innovative applications in both the discovery and process chemistry realms. I envision that these projects will not only serve as the groundwork for future methodologies and syntheses but also inspire advancements in the design of novel molecules.
■590 ▼aSchool code: 0127.
■650 4▼aChemistry
■650 4▼aPharmaceutical sciences
■650 4▼aBiochemistry
■650 4▼aOrganic chemistry
■653 ▼aPhotoredox catalysis
■653 ▼aKinase inhibitors
■653 ▼a2-Azanorbornane
■653 ▼aLate-stage functionalization
■690 ▼a0485
■690 ▼a0487
■690 ▼a0490
■690 ▼a0572
■71020▼aUniversity of Michigan▼bChemistry.
■7730 ▼tDissertations Abstracts International▼g87-02B.
■790 ▼a0127
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359817▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
