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Enteric Neurons Utilize Mechanoreceptor Piezo1 to Sense Force and Regulate Intestinal Motility and Inflammation
Enteric Neurons Utilize Mechanoreceptor Piezo1 to Sense Force and Regulate Intestinal Motility and Inflammation
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202103535
- ISBN
- 9798280718425
- DDC
- 616
- 저자명
- Rose, Lillian.
- 서명/저자
- Enteric Neurons Utilize Mechanoreceptor Piezo1 to Sense Force and Regulate Intestinal Motility and Inflammation
- 발행사항
- [Sl] : Harvard University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 94 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
- 주기사항
- Advisor: Jackson, Ruaidhri.
- 학위논문주기
- Thesis (Ph.D.)--Harvard University, 2025.
- 초록/해제
- 요약The enteric nervous system (ENS) controls many gastrointestinal (GI) functions including motility which occurs via peristalsis- the rhythmic wave-like contractions that transit food boluses through the intestines, creating a plethora of mechanical stimuli. However, whether the enteric neurons that control this process can sense these self-generated mechanical stimuli is unknown. During digestive dysfunction in inflammatory bowel disease (IBD) there are major alterations in motility and pressure in the intestines which are concurrent with inflammation. As enteric neurons control motility which creates abundant mechanical stimuli, and since mechanical stimuli as well as enteric neurons can modulate inflammation, I wanted to investigate the role of mechanosensation in enteric neurons. I hypothesized that enteric neuronal sensation of mechanical force is required for regulating tissue homeostasis and inflammation. Herein, I establish that the mechanosensor Piezo1 is functionally expressed in cholinergic enteric neurons. Piezo1-deficiency reduces neuronal activity and slows peristalsis. Further, I uncover that Piezo1-dependent enteric cholinergic responses prevent aberrant inflammation during colitis. Finally, I discover that enteric neurons release canonical cholinergic neurotransmitter acetylcholine in response to mechanical stimuli which can mediate both motility and immune response. This work is the first to determine how the ENS senses and responds to mechanical force.
- 일반주제명
- Neurosciences
- 일반주제명
- Health sciences
- 키워드
- Enteric neurons
- 키워드
- Mechanosensation
- 키워드
- Piezo
- 기타저자
- Harvard University Neuroscience
- 기본자료저록
- Dissertations Abstracts International. 86-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798280718425
■035 ▼a(MiAaPQ)AAI32040370
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aRose, Lillian.▼0(orcid)0000-0002-0597-3421
■24510▼aEnteric Neurons Utilize Mechanoreceptor Piezo1 to Sense Force and Regulate Intestinal Motility and Inflammation
■260 ▼a[Sl]▼bHarvard University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a94 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-12, Section: B.
■500 ▼aAdvisor: Jackson, Ruaidhri.
■5021 ▼aThesis (Ph.D.)--Harvard University, 2025.
■520 ▼aThe enteric nervous system (ENS) controls many gastrointestinal (GI) functions including motility which occurs via peristalsis- the rhythmic wave-like contractions that transit food boluses through the intestines, creating a plethora of mechanical stimuli. However, whether the enteric neurons that control this process can sense these self-generated mechanical stimuli is unknown. During digestive dysfunction in inflammatory bowel disease (IBD) there are major alterations in motility and pressure in the intestines which are concurrent with inflammation. As enteric neurons control motility which creates abundant mechanical stimuli, and since mechanical stimuli as well as enteric neurons can modulate inflammation, I wanted to investigate the role of mechanosensation in enteric neurons. I hypothesized that enteric neuronal sensation of mechanical force is required for regulating tissue homeostasis and inflammation. Herein, I establish that the mechanosensor Piezo1 is functionally expressed in cholinergic enteric neurons. Piezo1-deficiency reduces neuronal activity and slows peristalsis. Further, I uncover that Piezo1-dependent enteric cholinergic responses prevent aberrant inflammation during colitis. Finally, I discover that enteric neurons release canonical cholinergic neurotransmitter acetylcholine in response to mechanical stimuli which can mediate both motility and immune response. This work is the first to determine how the ENS senses and responds to mechanical force.
■590 ▼aSchool code: 0084.
■650 4▼aNeurosciences
■650 4▼aHealth sciences
■653 ▼aEnteric nervous system
■653 ▼aEnteric neurons
■653 ▼aInflammatory bowel disease
■653 ▼aMechanosensation
■653 ▼aPiezo
■690 ▼a0317
■690 ▼a0566
■71020▼aHarvard University▼bNeuroscience.
■7730 ▼tDissertations Abstracts International▼g86-12B.
■790 ▼a0084
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17357601▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
