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Circumventing Premetalated Reagents: Transition Metal-Catalyzed C-C Bond Forming Reactions and Synthetic Applications
Circumventing Premetalated Reagents: Transition Metal-Catalyzed C-C Bond Forming Reactions and Synthetic Applications
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260311091542.5
- ISBN
- 9798270232252
- DDC
- 540
- 서명/저자
- Circumventing Premetalated Reagents: Transition Metal-Catalyzed C-C Bond Forming Reactions and Synthetic Applications / Jonathan Zak Shezaf
- 발행사항
- [Sl] : The University of Texas at Austin, 2025
- 형태사항
- 1 electronic resource (1426 pages)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-06, Section: B.
- 주기사항
- Advisors: Krische, Michael J. Committee members: Kaoud, Tamer; Hull, Kami L.; Callmann, Cassandra.
- 학위논문주기
- - Ph.D. : The University of Texas at Austin, 2025.
- 초록/해제
- 요약Carbon-carbon bond-forming reactions are key in the construction of natural products and industrially relevant chemicals. However, many C-C bond-forming reactions require stoichiometric metallic or pre-metalated reagents, which may be hazardous or toxic. Described herein, are the development of methodologies, which circumvent the need for such reagents, primarily mediated by ruthenium-catalyzed hydrogen auto-transfer in carbonyl addition chemistry. Many of these transformations exploit the reducing capability of alcohols to generate organometallic nucleophiles from π-unsaturated feedstock chemicals resulting in products of C-C coupling. For asymmetric reactions, the role of iodide in defining stereogenicity-at-ruthenium and therefrom enhanced enantioselectivities, has been elucidated. Furthermore, using these tenants of hydrogen-auto transfer the development of methods towards the C-H alkylation of nitrogen-containing heteroarenes and palladium-catalyzed cross electrophile couplings is also described.
- 언어주기
- English
- 일반주제명
- Chemistry
- 일반주제명
- Materials science
- 일반주제명
- Chemical engineering
- 키워드
- Chemicals
- 기타저자
- The University of Texas at Austin Chemistry
- 기본자료저록
- Dissertations Abstracts International. 87-06B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798270232252
■040 ▼aMiAaPQD▼beng▼cMiAaPQD▼erda
■082 ▼a540
■1001 ▼aShezaf, Jonathan Zak▼eauthor.
■24510▼aCircumventing Premetalated Reagents: Transition Metal-Catalyzed C-C Bond Forming Reactions and Synthetic Applications ▼cJonathan Zak Shezaf
■260 ▼a[Sl]▼bThe University of Texas at Austin▼c2025
■264 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a1 electronic resource (1426 pages)
■336 ▼atext▼btxt▼2rdacontent
■337 ▼acomputer▼bc▼2rdamedia
■338 ▼aonline resource▼bcr▼2rdacarrier
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-06, Section: B.
■500 ▼aAdvisors: Krische, Michael J. Committee members: Kaoud, Tamer; Hull, Kami L.; Callmann, Cassandra.
■5021 ▼bPh.D.▼cThe University of Texas at Austin▼d2025.
■520 ▼aCarbon-carbon bond-forming reactions are key in the construction of natural products and industrially relevant chemicals. However, many C-C bond-forming reactions require stoichiometric metallic or pre-metalated reagents, which may be hazardous or toxic. Described herein, are the development of methodologies, which circumvent the need for such reagents, primarily mediated by ruthenium-catalyzed hydrogen auto-transfer in carbonyl addition chemistry. Many of these transformations exploit the reducing capability of alcohols to generate organometallic nucleophiles from π-unsaturated feedstock chemicals resulting in products of C-C coupling. For asymmetric reactions, the role of iodide in defining stereogenicity-at-ruthenium and therefrom enhanced enantioselectivities, has been elucidated. Furthermore, using these tenants of hydrogen-auto transfer the development of methods towards the C-H alkylation of nitrogen-containing heteroarenes and palladium-catalyzed cross electrophile couplings is also described.
■546 ▼aEnglish
■590 ▼aSchool code: 0227
■650 4▼aChemistry
■650 4▼aMaterials science
■650 4▼aChemical engineering
■653 ▼aOrganometallic nucleophiles
■653 ▼aElectrophile couplings
■653 ▼aRuthenium-catalyzed hydrogen
■653 ▼aChemicals
■7102 ▼aThe University of Texas at Austin▼bChemistry.▼edegree granting institution.
■7201 ▼aKrische, Michael J.▼edegree supervisor.
■7730 ▼tDissertations Abstracts International▼g87-06B.
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17361222▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
