서브메뉴
검색
Surgery, Science, and the Models that Fall in Between: A Foray into Intra-Cavitary Adhesions
Surgery, Science, and the Models that Fall in Between: A Foray into Intra-Cavitary Adhesions
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260311091512.5
- ISBN
- 9798286427291
- DDC
- 572.86
- 서명/저자
- Surgery, Science, and the Models that Fall in Between: A Foray into Intra-Cavitary Adhesions / Holly Nicole Blackburn
- 발행사항
- [Sl] : Yale University, 2025
- 형태사항
- 1 electronic resource (163 pages)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
- 주기사항
- Advisors: Flavell, Richard A. Committee members: Abraham, Clara; Ahuja, Nita; Craft, Joseph E.; Rothlin, Carla V.
- 학위논문주기
- - Ph.D. : Yale University, 2025.
- 초록/해제
- 요약Physiologic fibrosis is a necessary feature of multicellular life; however, when pathologic fibrosis ensues no organ is safe from the accumulation of extracellular matrix proteins. To study fibrosis and other diseases, there is a need for improved animal models that better recapitulate the disease in humans. Here, we use surgical principles to develop, describe, and validate four novel mouse models to explore two major tissue types: fibrosis and secondary lymphoid organs. We employ these models in fibrosis to identify a vast world of mesenchymal heterogeneity. We show proof of principle for the biologic process of convergent plasticity-a phenomenon in which distinct, steady-state adult lineages transdifferentiate into a transcriptionally identical daughter population, irrespective of ontogeny. We identify a subset of cells that arise through convergent plasticity, which are necessary in the development and maintenance of thick fibrotic adhesions. Through this work, we hope there comes a respite from the vicious cycle of adhesions disruption and re-formation.
- 언어주기
- English
- 일반주제명
- Immunology
- 일반주제명
- Medicine
- 일반주제명
- Surgery
- 키워드
- Adhesions
- 키워드
- Fibrosis
- 키워드
- Lineage-tracing
- 기타저자
- Yale University Investigative Medicine
- 기본자료저록
- Dissertations Abstracts International. 86-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008260311s2025 us eng d■001000017356743
■00520260311091512.5
■006m o d
■007cr|nu||||||||
■020 ▼a9798286427291
■040 ▼aMiAaPQD▼beng▼cMiAaPQD▼erda
■082 ▼a572.86
■1001 ▼aBlackburn, Holly Nicole▼eauthor.
■24510▼aSurgery, Science, and the Models that Fall in Between: A Foray into Intra-Cavitary Adhesions ▼cHolly Nicole Blackburn
■260 ▼a[Sl]▼bYale University▼c2025
■264 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a1 electronic resource (163 pages)
■336 ▼atext▼btxt▼2rdacontent
■337 ▼acomputer▼bc▼2rdamedia
■338 ▼aonline resource▼bcr▼2rdacarrier
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-12, Section: B.
■500 ▼aAdvisors: Flavell, Richard A. Committee members: Abraham, Clara; Ahuja, Nita; Craft, Joseph E.; Rothlin, Carla V.
■5021 ▼bPh.D.▼cYale University▼d2025.
■520 ▼aPhysiologic fibrosis is a necessary feature of multicellular life; however, when pathologic fibrosis ensues no organ is safe from the accumulation of extracellular matrix proteins. To study fibrosis and other diseases, there is a need for improved animal models that better recapitulate the disease in humans. Here, we use surgical principles to develop, describe, and validate four novel mouse models to explore two major tissue types: fibrosis and secondary lymphoid organs. We employ these models in fibrosis to identify a vast world of mesenchymal heterogeneity. We show proof of principle for the biologic process of convergent plasticity-a phenomenon in which distinct, steady-state adult lineages transdifferentiate into a transcriptionally identical daughter population, irrespective of ontogeny. We identify a subset of cells that arise through convergent plasticity, which are necessary in the development and maintenance of thick fibrotic adhesions. Through this work, we hope there comes a respite from the vicious cycle of adhesions disruption and re-formation.
■546 ▼aEnglish
■590 ▼aSchool code: 0265
■650 4▼aImmunology
■650 4▼aMedicine
■650 4▼aSurgery
■653 ▼aAdhesions
■653 ▼aCellular heterogeneity
■653 ▼aFibrosis
■653 ▼aLineage-tracing
■653 ▼aSingle-cell RNA sequencing
■7102 ▼aYale University▼bInvestigative Medicine.▼edegree granting institution.
■7201 ▼aFlavell, Richard A.▼edegree supervisor.
■7730 ▼tDissertations Abstracts International▼g86-12B.
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17356743▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
