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Investigation of the Formation and Dissolution of Dental Enamel Using Murine Models
Investigation of the Formation and Dissolution of Dental Enamel Using Murine Models
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260311091505.5
- ISBN
- 9798315797449
- DDC
- 339.4
- 저자명
- Boyer, Sarah
- 서명/저자
- Investigation of the Formation and Dissolution of Dental Enamel Using Murine Models / Sarah Boyer
- 발행사항
- [Sl] : Northwestern University, 2025
- 형태사항
- 1 electronic resource (194 pages)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
- 주기사항
- Advisors: Joester, Derk Committee members: Stock, Stuart; Bedzyk, Michael; Shull, Kenneth.
- 학위논문주기
- - Ph.D. : Northwestern University, 2025.
- 초록/해제
- 요약Enamel is a multiscale complex bio composite whose composition and structure are critical to its function. It is acellular, and once the cells are lost, enamel regeneration is limited to remineralization from ions in saliva. This emphasizes the importance of having functional enamel initially and preventing the mineral loss of native enamel. Errors in enamel formation, such as amelogenesis imperfecta, or acquired defects after the enamel erupts, such as tooth decay, can lead to defective enamel that requires costly and painful treatment.Our motivation for this thesis is to better understand enamel as a material, specifically how errors in enamel formation or acquired enamel defects occur. The overarching goal of our work is to help advance management and treatment, decrease the burden of these diseases, improve quality of life, and reduce the exorbitant expenditure on dental care in the US.In this thesis, we will address several topics that examine the formation and dissolution of enamel. We first introduce enamel, amelogenesis, caries, and our motivation for this work. We then outline the development and refinement of a convolutional neural network for the semantic segmentation of caries lesions in molars from an induced caries rodent model with the additional variable of dietary fluoride. This offers a fast and unbiased method to identify lesions for further investigation through a developed pipeline. We can extract full-volume and individual lesion class statistics using volume and mineral density measurements. We developed code for the automatic extraction of averaged mineral density line profiles across the lesion to compare the structures formed over time with or without fluoride exposure. This initial work investigated fluoride's role in subsurface lesion formation. We further investigate the impact of a novel fluoride treatment on enamel that combines iron oxide and stannous fluoride.In addition to investigating tooth decay, we are also interested in the other end of biomineralization: enamel synthesis. We study the use of mutations in mouse models to understand the role of organics in amelogenesis. We examine a mutant mouse line of the second most abundant enamel matrix protein and mouse models with alleles that can be used to control mutations temporally and spatially.
- 언어주기
- English
- 일반주제명
- Materials science
- 일반주제명
- Engineering
- 일반주제명
- Dentistry
- 키워드
- Enamel
- 키워드
- Murine models
- 키워드
- Dental care
- 기타저자
- Northwestern University Materials Science and Engineering
- 기본자료저록
- Dissertations Abstracts International. 86-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008260311s2025 us eng d■001000017356942
■00520260311091505.5
■006m o d
■007cr|nu||||||||
■020 ▼a9798315797449
■040 ▼aMiAaPQD▼beng▼cMiAaPQD▼erda
■082 ▼a339.4
■1001 ▼aBoyer, Sarah▼eauthor.
■24510▼aInvestigation of the Formation and Dissolution of Dental Enamel Using Murine Models ▼cSarah Boyer
■260 ▼a[Sl]▼bNorthwestern University▼c2025
■264 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a1 electronic resource (194 pages)
■336 ▼atext▼btxt▼2rdacontent
■337 ▼acomputer▼bc▼2rdamedia
■338 ▼aonline resource▼bcr▼2rdacarrier
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-12, Section: B.
■500 ▼aAdvisors: Joester, Derk Committee members: Stock, Stuart; Bedzyk, Michael; Shull, Kenneth.
■5021 ▼bPh.D.▼cNorthwestern University▼d2025.
■520 ▼aEnamel is a multiscale complex bio composite whose composition and structure are critical to its function. It is acellular, and once the cells are lost, enamel regeneration is limited to remineralization from ions in saliva. This emphasizes the importance of having functional enamel initially and preventing the mineral loss of native enamel. Errors in enamel formation, such as amelogenesis imperfecta, or acquired defects after the enamel erupts, such as tooth decay, can lead to defective enamel that requires costly and painful treatment.Our motivation for this thesis is to better understand enamel as a material, specifically how errors in enamel formation or acquired enamel defects occur. The overarching goal of our work is to help advance management and treatment, decrease the burden of these diseases, improve quality of life, and reduce the exorbitant expenditure on dental care in the US.In this thesis, we will address several topics that examine the formation and dissolution of enamel. We first introduce enamel, amelogenesis, caries, and our motivation for this work. We then outline the development and refinement of a convolutional neural network for the semantic segmentation of caries lesions in molars from an induced caries rodent model with the additional variable of dietary fluoride. This offers a fast and unbiased method to identify lesions for further investigation through a developed pipeline. We can extract full-volume and individual lesion class statistics using volume and mineral density measurements. We developed code for the automatic extraction of averaged mineral density line profiles across the lesion to compare the structures formed over time with or without fluoride exposure. This initial work investigated fluoride's role in subsurface lesion formation. We further investigate the impact of a novel fluoride treatment on enamel that combines iron oxide and stannous fluoride.In addition to investigating tooth decay, we are also interested in the other end of biomineralization: enamel synthesis. We study the use of mutations in mouse models to understand the role of organics in amelogenesis. We examine a mutant mouse line of the second most abundant enamel matrix protein and mouse models with alleles that can be used to control mutations temporally and spatially.
■546 ▼aEnglish
■590 ▼aSchool code: 0163
■650 4▼aMaterials science
■650 4▼aEngineering
■650 4▼aDentistry
■653 ▼aEnamel
■653 ▼aMurine models
■653 ▼aDental care
■653 ▼aExorbitant expenditure
■7102 ▼aNorthwestern University▼bMaterials Science and Engineering.▼edegree granting institution.
■7201 ▼aJoester, Derk▼edegree supervisor.
■7730 ▼tDissertations Abstracts International▼g86-12B.
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17356942▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
