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Nonapoptotic Role of EGL-1 in Exopher Production and Neuronal Health in Caenorhabditis elegans
Nonapoptotic Role of EGL-1 in Exopher Production and Neuronal Health in Caenorhabditis elegans
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260311091515.5
- ISBN
- 9798270229573
- DDC
- 571
- 저자명
- Wu, Zheng
- 서명/저자
- Nonapoptotic Role of EGL-1 in Exopher Production and Neuronal Health in <em>Caenorhabditis elegans</em> / Zheng Wu
- 발행사항
- [Sl] : The University of Texas at Austin, 2025
- 형태사항
- 1 electronic resource (85 pages)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-06, Section: B.
- 주기사항
- Advisors: Pierce, Jonathan T. Committee members: Atkinson, Nigel; Eberhart, Johann; Brumback, Audrey.
- 학위논문주기
- - Ph.D. : The University of Texas at Austin, 2025.
- 초록/해제
- 요약While traditionally studied for their pro-apoptotic functions in activating the caspase, research suggests BH3-only proteins also have other roles such as mitochondria dynamics regulation. Here, we find that EGL-1, the BH3-only protein in the nematode Caenorhabditis elegans, promotes the cell-autonomous production of exophers in adult neurons. Exophers are large, micron-scale vesicles that are ejected from the cell and contain cellular components such as mitochondria. EGL-1 facilitates exopher production potentially through regulation of mitochondrial dynamics. Moreover, an endogenous, low level of EGL-1 expression appears to benefit dendritic health. Our findings provide insights into the role of neuronal BH3-only protein in mitochondrial dynamics, downstream exopher production, and ultimately neuronal health.
- 언어주기
- English
- 일반주제명
- Neurosciences
- 일반주제명
- Physiology
- 일반주제명
- Cellular biology
- 키워드
- Neuronal health
- 키워드
- Exophers
- 기타저자
- The University of Texas at Austin Cellular and Molecular Biology
- 기본자료저록
- Dissertations Abstracts International. 87-06B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798270229573
■040 ▼aMiAaPQD▼beng▼cMiAaPQD▼erda
■082 ▼a571
■1001 ▼aWu, Zheng▼eauthor.
■24510▼aNonapoptotic Role of EGL-1 in Exopher Production and Neuronal Health in emCaenorhabditis elegans/em ▼cZheng Wu
■260 ▼a[Sl]▼bThe University of Texas at Austin▼c2025
■264 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a1 electronic resource (85 pages)
■336 ▼atext▼btxt▼2rdacontent
■337 ▼acomputer▼bc▼2rdamedia
■338 ▼aonline resource▼bcr▼2rdacarrier
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-06, Section: B.
■500 ▼aAdvisors: Pierce, Jonathan T. Committee members: Atkinson, Nigel; Eberhart, Johann; Brumback, Audrey.
■5021 ▼bPh.D.▼cThe University of Texas at Austin▼d2025.
■520 ▼aWhile traditionally studied for their pro-apoptotic functions in activating the caspase, research suggests BH3-only proteins also have other roles such as mitochondria dynamics regulation. Here, we find that EGL-1, the BH3-only protein in the nematode Caenorhabditis elegans, promotes the cell-autonomous production of exophers in adult neurons. Exophers are large, micron-scale vesicles that are ejected from the cell and contain cellular components such as mitochondria. EGL-1 facilitates exopher production potentially through regulation of mitochondrial dynamics. Moreover, an endogenous, low level of EGL-1 expression appears to benefit dendritic health. Our findings provide insights into the role of neuronal BH3-only protein in mitochondrial dynamics, downstream exopher production, and ultimately neuronal health.
■546 ▼aEnglish
■590 ▼aSchool code: 0227
■650 4▼aNeurosciences
■650 4▼aPhysiology
■650 4▼aCellular biology
■653 ▼aCaenorhabditis elegans
■653 ▼aNeuronal health
■653 ▼aCellular components
■653 ▼aExophers
■7102 ▼aThe University of Texas at Austin▼bCellular and Molecular Biology.▼edegree granting institution.
■7201 ▼aPierce, Jonathan T. ▼edegree supervisor.
■7730 ▼tDissertations Abstracts International▼g87-06B.
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17361150▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
