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Phase Field Models of Tissue Mechanics and Cell Migration
Phase Field Models of Tissue Mechanics and Cell Migration
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202104719
- ISBN
- 9798297683945
- DDC
- 530
- 서명/저자
- Phase Field Models of Tissue Mechanics and Cell Migration
- 발행사항
- [Sl] : University of California, Santa Barbara, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 215 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-04, Section: B.
- 주기사항
- Advisor: Marchetti, M. Cristina.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Santa Barbara, 2025.
- 초록/해제
- 요약Biological tissues are living materials whose complex mechanical and rheological properties regulate many functions of life. Because tissues are made from individual cells, they pose an interesting opportunity for physics to connect tissue scale properties with single-cell scale ones. However, tissues are soft, living materials which poses a challenge for physics-based approaches. This thesis will consider a particular model for cell shape, known as the phase field model, and apply it to problems in tissue mechanics and cell migration. We first study a method for reading out rheological properties of a tissue via motion of a forced probe inside a confluent tissue. We analyze the motion of the probe as well as the deformations induced in the tissue. We find that the existence of a threshold force for the motion of the probe can be a measure of the rheological state, and study its dependence on cell properties such as motility and tension. We then move to the case of a non-confluent tissue and examine how cell motility and tension affect aggregation. We connect these results to existing active matter physics theories of motility-induced phase separation. The deformability of the cells can significantly affect their ability to aggregate and this effect can be understood in terms of the duration of simple two-body collisions. We also make developments on the modeling side by explicitly connecting two dimensional phase field models with three dimensional ones and incorporate a cell-cell friction which captures the role of cell adhesion proteins, such as E-cadherins. The intercellular friction can significantly affect the solid-liquid transition and creates spatial velocity correlations within the tissue. Finally, we propose intercellular friction as a mechanism for the emergence of local hexatic and nematic order in epithelial tissues. The correlations in defects in each of these kinds of order can be understood in terms of a simple geometric picture.
- 일반주제명
- Physics
- 일반주제명
- Biophysics
- 일반주제명
- Cellular biology
- 키워드
- Cell migration
- 키워드
- Tissue rheology
- 키워드
- Cell motility
- 기타저자
- University of California, Santa Barbara Physics
- 기본자료저록
- Dissertations Abstracts International. 87-04B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520260202104719
■006m o d
■007cr#unu||||||||
■020 ▼a9798297683945
■035 ▼a(MiAaPQ)AAI32120965
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a530
■1001 ▼aHopkins, Austin Curran.
■24510▼aPhase Field Models of Tissue Mechanics and Cell Migration
■260 ▼a[Sl]▼bUniversity of California, Santa Barbara▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a215 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-04, Section: B.
■500 ▼aAdvisor: Marchetti, M. Cristina.
■5021 ▼aThesis (Ph.D.)--University of California, Santa Barbara, 2025.
■520 ▼aBiological tissues are living materials whose complex mechanical and rheological properties regulate many functions of life. Because tissues are made from individual cells, they pose an interesting opportunity for physics to connect tissue scale properties with single-cell scale ones. However, tissues are soft, living materials which poses a challenge for physics-based approaches. This thesis will consider a particular model for cell shape, known as the phase field model, and apply it to problems in tissue mechanics and cell migration. We first study a method for reading out rheological properties of a tissue via motion of a forced probe inside a confluent tissue. We analyze the motion of the probe as well as the deformations induced in the tissue. We find that the existence of a threshold force for the motion of the probe can be a measure of the rheological state, and study its dependence on cell properties such as motility and tension. We then move to the case of a non-confluent tissue and examine how cell motility and tension affect aggregation. We connect these results to existing active matter physics theories of motility-induced phase separation. The deformability of the cells can significantly affect their ability to aggregate and this effect can be understood in terms of the duration of simple two-body collisions. We also make developments on the modeling side by explicitly connecting two dimensional phase field models with three dimensional ones and incorporate a cell-cell friction which captures the role of cell adhesion proteins, such as E-cadherins. The intercellular friction can significantly affect the solid-liquid transition and creates spatial velocity correlations within the tissue. Finally, we propose intercellular friction as a mechanism for the emergence of local hexatic and nematic order in epithelial tissues. The correlations in defects in each of these kinds of order can be understood in terms of a simple geometric picture.
■590 ▼aSchool code: 0035.
■650 4▼aPhysics
■650 4▼aBiophysics
■650 4▼aCellular biology
■653 ▼aCell migration
■653 ▼aPhase field model
■653 ▼aTissue rheology
■653 ▼aBiological tissues
■653 ▼aCell motility
■690 ▼a0605
■690 ▼a0786
■690 ▼a0379
■71020▼aUniversity of California, Santa Barbara▼bPhysics.
■7730 ▼tDissertations Abstracts International▼g87-04B.
■790 ▼a0035
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17358559▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
