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Cell-Surface RNA-Binding Proteins
Cell-Surface RNA-Binding Proteins
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202103541
- ISBN
- 9798280714106
- DDC
- 574
- 저자명
- Perr, Jonathan.
- 서명/저자
- Cell-Surface RNA-Binding Proteins
- 발행사항
- [Sl] : Harvard University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 98 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
- 주기사항
- Advisor: Flynn, Ryan A.
- 학위논문주기
- Thesis (Ph.D.)--Harvard University, 2025.
- 초록/해제
- 요약The composition and organization of the cell surface determine how cells interact with their environment. Traditionally, glycosylated transmembrane proteins were thought to be the major constituents of the external surface of the plasma membrane. Here, we provide evidence that a group of RNA-binding proteins (RBPs) is present on the surface of living cells. These cell-surface RBPs (csRBPs) precisely organize into well-defined nanoclusters enriched for multiple RBPs and glycoRNAs, and their clustering can be disrupted by extracellular RNase addition. These glycoRNA-csRBP clusters further serve as sites of cell-surface interaction for the cell-penetrating peptide trans-activator of transcription (TAT). Removal of RNA from the cell surface, or loss of RNA-binding activity by TAT, causes defects in TAT cell internalization. Together, we provide evidence of an expanded view of the cell surface by positioning glycoRNA-csRBP clusters as a regulator of communication between cells and the extracellular environment.
- 일반주제명
- Molecular biology
- 일반주제명
- Cellular biology
- 일반주제명
- Biology
- 일반주제명
- Genetics
- 키워드
- Cell surface
- 키워드
- Glycorna
- 기타저자
- Harvard University Biology Molecular and Cellular
- 기본자료저록
- Dissertations Abstracts International. 86-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798280714106
■035 ▼a(MiAaPQ)AAI32040937
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aPerr, Jonathan.▼0(orcid)0000-0002-0014-2565
■24510▼aCell-Surface RNA-Binding Proteins
■260 ▼a[Sl]▼bHarvard University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a98 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-12, Section: B.
■500 ▼aAdvisor: Flynn, Ryan A.
■5021 ▼aThesis (Ph.D.)--Harvard University, 2025.
■520 ▼aThe composition and organization of the cell surface determine how cells interact with their environment. Traditionally, glycosylated transmembrane proteins were thought to be the major constituents of the external surface of the plasma membrane. Here, we provide evidence that a group of RNA-binding proteins (RBPs) is present on the surface of living cells. These cell-surface RBPs (csRBPs) precisely organize into well-defined nanoclusters enriched for multiple RBPs and glycoRNAs, and their clustering can be disrupted by extracellular RNase addition. These glycoRNA-csRBP clusters further serve as sites of cell-surface interaction for the cell-penetrating peptide trans-activator of transcription (TAT). Removal of RNA from the cell surface, or loss of RNA-binding activity by TAT, causes defects in TAT cell internalization. Together, we provide evidence of an expanded view of the cell surface by positioning glycoRNA-csRBP clusters as a regulator of communication between cells and the extracellular environment.
■590 ▼aSchool code: 0084.
■650 4▼aMolecular biology
■650 4▼aCellular biology
■650 4▼aBiology
■650 4▼aGenetics
■653 ▼aCell surface
■653 ▼aCell-penetrating peptide
■653 ▼aGlycorna
■653 ▼aRNA-binding protein
■653 ▼aTrans-activator of transcription
■690 ▼a0307
■690 ▼a0379
■690 ▼a0306
■690 ▼a0369
■71020▼aHarvard University▼bBiology, Molecular and Cellular.
■7730 ▼tDissertations Abstracts International▼g86-12B.
■790 ▼a0084
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17357649▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
