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Hydrazine-Mediated Carbonyl-Olefin Metathesis: Analysis of Hydrazine Structures, Ring-Closing Reactions, and Ring-Opening Reactions
Hydrazine-Mediated Carbonyl-Olefin Metathesis: Analysis of Hydrazine Structures, Ring-Closing Reactions, and Ring-Opening Reactions
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202104808
- ISBN
- 9798293822201
- DDC
- 547
- 서명/저자
- Hydrazine-Mediated Carbonyl-Olefin Metathesis: Analysis of Hydrazine Structures, Ring-Closing Reactions, and Ring-Opening Reactions
- 발행사항
- [Sl] : Cornell University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 256 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-03, Section: B.
- 주기사항
- Advisor: Lambert, Tristan.
- 학위논문주기
- Thesis (Ph.D.)--Cornell University, 2025.
- 초록/해제
- 요약For years, the Lambert group has studied and exploited the use of hydrazines for carbonyl-olefin metathesis (COM). In trying to extend the capabilities of hydrazines, challenges have been identified that need to be addressed. This dissertation takes a closer look into the COM systems in addition to changes in the hydrazine system to identify these challenges, proved insights and propose potential solutions that could facilitate further developments. Chapter 1 of this dissertation introduces methods used for COM transformations. Chapter 2 focuses on the synthesis of 2,3-dihydrobenzoxepines via hydrazine-catalyzed ring-closing COM (RCCOM). The analysis of these reactions identifies problems of both substrate and hydrazine stability. Using 20 mol% of the [2.2.1] hydrazine, the product was obtained in 55% yield.Chapter 3 focuses on the analysis of norbornene reactivity as it pertains to ring-opening metathesis polymerization (ROMP) using hydrazines. Key to this discussion was the identification of the decomposition of our hydrazine salt and its replacement. Additionally, the analysis of the reaction between hydrazine and norbornene exposes a potential obstacle for efficient catalysis moving forward. Chapter 4 investigates the ring-opening COM (ROCOM) of cyclooctenes, with an investigation into the cyclic olefins that are tolerated with hydrazines and revels problematic steps.Chapter 5 presents hydrazines that were prepared and tested with various COM reactions, discussing the findings and what conclusions can be suggested from the results.
- 일반주제명
- Organic chemistry
- 일반주제명
- Chemistry
- 일반주제명
- Inorganic chemistry
- 기타저자
- Cornell University Chemistry and Chemical Biology
- 기본자료저록
- Dissertations Abstracts International. 87-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■006m o d
■007cr#unu||||||||
■020 ▼a9798293822201
■035 ▼a(MiAaPQ)AAI32166587
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a547
■1001 ▼aDe La Rosa, Jose Miguel.▼0(orcid)0009-0003-7214-8178
■24510▼aHydrazine-Mediated Carbonyl-Olefin Metathesis: Analysis of Hydrazine Structures, Ring-Closing Reactions, and Ring-Opening Reactions
■260 ▼a[Sl]▼bCornell University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a256 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-03, Section: B.
■500 ▼aAdvisor: Lambert, Tristan.
■5021 ▼aThesis (Ph.D.)--Cornell University, 2025.
■520 ▼aFor years, the Lambert group has studied and exploited the use of hydrazines for carbonyl-olefin metathesis (COM). In trying to extend the capabilities of hydrazines, challenges have been identified that need to be addressed. This dissertation takes a closer look into the COM systems in addition to changes in the hydrazine system to identify these challenges, proved insights and propose potential solutions that could facilitate further developments. Chapter 1 of this dissertation introduces methods used for COM transformations. Chapter 2 focuses on the synthesis of 2,3-dihydrobenzoxepines via hydrazine-catalyzed ring-closing COM (RCCOM). The analysis of these reactions identifies problems of both substrate and hydrazine stability. Using 20 mol% of the [2.2.1] hydrazine, the product was obtained in 55% yield.Chapter 3 focuses on the analysis of norbornene reactivity as it pertains to ring-opening metathesis polymerization (ROMP) using hydrazines. Key to this discussion was the identification of the decomposition of our hydrazine salt and its replacement. Additionally, the analysis of the reaction between hydrazine and norbornene exposes a potential obstacle for efficient catalysis moving forward. Chapter 4 investigates the ring-opening COM (ROCOM) of cyclooctenes, with an investigation into the cyclic olefins that are tolerated with hydrazines and revels problematic steps.Chapter 5 presents hydrazines that were prepared and tested with various COM reactions, discussing the findings and what conclusions can be suggested from the results.
■590 ▼aSchool code: 0058.
■650 4▼aOrganic chemistry
■650 4▼aChemistry
■650 4▼aInorganic chemistry
■653 ▼aCarbonyl-olefin metathesis
■653 ▼aHydrazine catalyst
■690 ▼a0490
■690 ▼a0488
■690 ▼a0485
■71020▼aCornell University▼bChemistry and Chemical Biology.
■7730 ▼tDissertations Abstracts International▼g87-03B.
■790 ▼a0058
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17358912▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
