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Functional and Structural Study of Alphavirus Receptors
Functional and Structural Study of Alphavirus Receptors
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105143
- ISBN
- 9798265410184
- DDC
- 576.6
- 저자명
- Li, Wanyu.
- 서명/저자
- Functional and Structural Study of Alphavirus Receptors
- 발행사항
- [Sl] : Harvard University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 290 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-05, Section: B.
- 주기사항
- Advisor: Abraham, Jonathan.
- 학위논문주기
- Thesis (Ph.D.)--Harvard University, 2025.
- 초록/해제
- 요약Alphaviruses are single-stranded, positive sense RNA viruses that can cause epidemic polyarthritis or encephalitis in humans and animals. Encephalitic alphaviruses include eastern equine encephalitis virus (EEEV), western equine encephalitis virus (WEEV), and Venezuelan equine encephalitis virus (VEEV). While EEEV and VEEV currently cause regionally contained outbreaks, their emergence into epidemics could be devastating. WEEV historically caused explosive epidemics of viral encephalitis in North America, but has since rapidly declined with the last case documented in the 1990s, a poorly understood process termed "submergence". Alphaviruses enter host cells through attachment to specific protein receptors on the cell surface, a critical step targeted by antibodies and entry-blocking therapeutics. Here, we combine functional assays with in vitro, in vivo models and cryogenic electron microscopy (cryo-EM) to characterize the interaction of EEEV with its previously identified receptor, and of WEEV with newly identified receptors in this study. Our results provide insight into the ability of EEEV and WEEV to invade the central nervous system, and the molecular basis for the submergence of WEEV as a human and veterinary pathogen in North America, with implications for outbreak preparedness and the development of antiviral therapeutics.
- 일반주제명
- Virology
- 일반주제명
- Microbiology
- 일반주제명
- Pathology
- 키워드
- Arbovirus
- 키워드
- Virus evolution
- 기타저자
- Harvard University Virology
- 기본자료저록
- Dissertations Abstracts International. 87-05B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798265410184
■035 ▼a(MiAaPQ)AAI32240916
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a576.6
■1001 ▼aLi, Wanyu.
■24510▼aFunctional and Structural Study of Alphavirus Receptors
■260 ▼a[Sl]▼bHarvard University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a290 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-05, Section: B.
■500 ▼aAdvisor: Abraham, Jonathan.
■5021 ▼aThesis (Ph.D.)--Harvard University, 2025.
■520 ▼aAlphaviruses are single-stranded, positive sense RNA viruses that can cause epidemic polyarthritis or encephalitis in humans and animals. Encephalitic alphaviruses include eastern equine encephalitis virus (EEEV), western equine encephalitis virus (WEEV), and Venezuelan equine encephalitis virus (VEEV). While EEEV and VEEV currently cause regionally contained outbreaks, their emergence into epidemics could be devastating. WEEV historically caused explosive epidemics of viral encephalitis in North America, but has since rapidly declined with the last case documented in the 1990s, a poorly understood process termed "submergence". Alphaviruses enter host cells through attachment to specific protein receptors on the cell surface, a critical step targeted by antibodies and entry-blocking therapeutics. Here, we combine functional assays with in vitro, in vivo models and cryogenic electron microscopy (cryo-EM) to characterize the interaction of EEEV with its previously identified receptor, and of WEEV with newly identified receptors in this study. Our results provide insight into the ability of EEEV and WEEV to invade the central nervous system, and the molecular basis for the submergence of WEEV as a human and veterinary pathogen in North America, with implications for outbreak preparedness and the development of antiviral therapeutics.
■590 ▼aSchool code: 0084.
■650 4▼aVirology
■650 4▼aMicrobiology
■650 4▼aPathology
■653 ▼aArbovirus
■653 ▼aAlphavirus receptors
■653 ▼aVirus evolution
■653 ▼aVirus-host interaction
■690 ▼a0720
■690 ▼a0410
■690 ▼a0571
■71020▼aHarvard University▼bVirology.
■7730 ▼tDissertations Abstracts International▼g87-05B.
■790 ▼a0084
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359592▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
