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Genetic and Evolutionary Basis of Behavioral Variability in Drosophila melanogaster
Genetic and Evolutionary Basis of Behavioral Variability in Drosophila melanogaster
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105145
- ISBN
- 9798265410122
- DDC
- 574
- 저자명
- Lall, Shraddha.
- 서명/저자
- Genetic and Evolutionary Basis of Behavioral Variability in Drosophila melanogaster
- 발행사항
- [Sl] : Harvard University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 273 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-05, Section: B.
- 주기사항
- Advisor: de Bivort, Benjamin.
- 학위논문주기
- Thesis (Ph.D.)--Harvard University, 2025.
- 초록/해제
- 요약Behavioral individuality is a ubiquitous phenomenon. Animals from genetically homogeneous populations reared in identical environments display persistent and variable behavioral phenotypes. This behavioral variability can be heritable and potentially adaptive through a bet-hedging strategy, wherein genotypes that produce a range of behavioral phenotypes enhance their long term fitness in unpredictably fluctuating environments by increasing the probability that some individuals will express traits well-suited to the current conditions. In this dissertation, I investigate the genetic and evolutionary basis of behavioral variability in Drosophila melanogaster, combining theoretical modeling with experimental approaches to test its evolvability and underlying mechanisms.In Chapter 1, I develop a computational model to examine how variability responds to artificial selection. I compare family-based and individual-based selection strategies and show that family-based selection, where variability is measured across related individuals, is more effective than individual-based selection when the trait under selection is variance-based but not when it is mean-based. I further explore how population size, genetic architecture, and selection strength shape evolutionary outcomes. In Chapter 2, I apply these insights in a 21-generation artificial selection in fruit flies experiment targeting increased variability in locomotor handedness. I observe a consistent increase in behavioral variability over selection without a shift in mean turning bias. This evolved variability is polygenic and potentially has some sex-linked basis. I also identify changes in central complex morphology and correlated tradeoffs in mating success. In Chapter 3, we shift focus to thermal preference, an ecologically relevant behavior. Using a panel of inbred lines, we show that the mean and variability of thermal preference are both heritable, and genetically independent. Genome-wide association implicates spag, a co-chaperone of Hsp90, as a regulator of thermal preference variability. In Chapter 4, we investigate the genetic basis of the offspring number-body weight tradeoff using a composite offspring index. We identify candidate genes influencing this tradeoff and demonstrate through functional experiments that specific mutations alter the balance between offspring size and number. In the concluding chapter, I outline future directions, including experimental evolution approaches for studying bet-hedging. Together, this work shows that behavioral variability is an evolvable trait shaped by genetic and neuroanatomical factors.
- 일반주제명
- Biology
- 일반주제명
- Evolution & development
- 일반주제명
- Behavioral sciences
- 일반주제명
- Genetics
- 키워드
- Behavior
- 키워드
- Bet hedging
- 키워드
- Evolution
- 키워드
- Variability
- 기타저자
- Harvard University Biology Organismic and Evolutionary
- 기본자료저록
- Dissertations Abstracts International. 87-05B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520260202105145
■006m o d
■007cr#unu||||||||
■020 ▼a9798265410122
■035 ▼a(MiAaPQ)AAI32241121
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aLall, Shraddha.
■24510▼aGenetic and Evolutionary Basis of Behavioral Variability in Drosophila melanogaster
■260 ▼a[Sl]▼bHarvard University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a273 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-05, Section: B.
■500 ▼aAdvisor: de Bivort, Benjamin.
■5021 ▼aThesis (Ph.D.)--Harvard University, 2025.
■520 ▼aBehavioral individuality is a ubiquitous phenomenon. Animals from genetically homogeneous populations reared in identical environments display persistent and variable behavioral phenotypes. This behavioral variability can be heritable and potentially adaptive through a bet-hedging strategy, wherein genotypes that produce a range of behavioral phenotypes enhance their long term fitness in unpredictably fluctuating environments by increasing the probability that some individuals will express traits well-suited to the current conditions. In this dissertation, I investigate the genetic and evolutionary basis of behavioral variability in Drosophila melanogaster, combining theoretical modeling with experimental approaches to test its evolvability and underlying mechanisms.In Chapter 1, I develop a computational model to examine how variability responds to artificial selection. I compare family-based and individual-based selection strategies and show that family-based selection, where variability is measured across related individuals, is more effective than individual-based selection when the trait under selection is variance-based but not when it is mean-based. I further explore how population size, genetic architecture, and selection strength shape evolutionary outcomes. In Chapter 2, I apply these insights in a 21-generation artificial selection in fruit flies experiment targeting increased variability in locomotor handedness. I observe a consistent increase in behavioral variability over selection without a shift in mean turning bias. This evolved variability is polygenic and potentially has some sex-linked basis. I also identify changes in central complex morphology and correlated tradeoffs in mating success. In Chapter 3, we shift focus to thermal preference, an ecologically relevant behavior. Using a panel of inbred lines, we show that the mean and variability of thermal preference are both heritable, and genetically independent. Genome-wide association implicates spag, a co-chaperone of Hsp90, as a regulator of thermal preference variability. In Chapter 4, we investigate the genetic basis of the offspring number-body weight tradeoff using a composite offspring index. We identify candidate genes influencing this tradeoff and demonstrate through functional experiments that specific mutations alter the balance between offspring size and number. In the concluding chapter, I outline future directions, including experimental evolution approaches for studying bet-hedging. Together, this work shows that behavioral variability is an evolvable trait shaped by genetic and neuroanatomical factors.
■590 ▼aSchool code: 0084.
■650 4▼aBiology
■650 4▼aEvolution & development
■650 4▼aBehavioral sciences
■650 4▼aGenetics
■653 ▼aArtificial selection
■653 ▼aBehavior
■653 ▼aBet hedging
■653 ▼aDrosophila melanogaster
■653 ▼aEvolution
■653 ▼aVariability
■690 ▼a0306
■690 ▼a0412
■690 ▼a0602
■690 ▼a0369
■71020▼aHarvard University▼bBiology, Organismic and Evolutionary.
■7730 ▼tDissertations Abstracts International▼g87-05B.
■790 ▼a0084
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359608▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
