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Beyond the Back in Chronic Low Back Pain: Investigating Gut Microbiome and Plasma Cytokine Associations With Pain and Disability
Beyond the Back in Chronic Low Back Pain: Investigating Gut Microbiome and Plasma Cytokine Associations With Pain and Disability
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202103544
- ISBN
- 9798315703792
- DDC
- 614
- 서명/저자
- Beyond the Back in Chronic Low Back Pain: Investigating Gut Microbiome and Plasma Cytokine Associations With Pain and Disability
- 발행사항
- [Sl] : University of Pittsburgh, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 367 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-11, Section: B.
- 주기사항
- Advisor: Sowa, Gwendolyn;Piva, Sara R.
- 학위논문주기
- Thesis (Ph.D.)--University of Pittsburgh, 2025.
- 초록/해제
- 요약Chronic low back pain (CLBP) is a pervasive and debilitating condition influenced by complex biological, psychosocial, and environmental factors. Despite its global impact, the biological underpinnings of CLBP remain insufficiently understood, limiting the effectiveness of current treatment strategies. This dissertation investigates the role of systemic inflammation, assessed through circulating cytokines and the gut microbiome (GM), in the experience and clinical progression of CLBP. Through three complementary studies, this work examines the cross-sectional and longitudinal relationships between inflammatory biomarkers, pain, and disability in individuals with CLBP, aiming to inform more individualized rehabilitation strategies.The first study examines associations between GM composition and patient-reported pain and disability in a cross-sectional cohort of 867 individuals with CLBP. The results provide novel evidence linking gut microbiota composition to pain and disability, emphasizing the relevance of specific bacterial genera over global diversity indices. The second study examines systemic inflammation by measuring plasma cytokines in 936 individuals with CLBP. It reveals that both pro-inflammatory and anti-inflammatory cytokines are associated with pain and disability, with IL-6, IL-1ra, TNF-α, and IL-10 emerging as key markers. These findings suggest that distinct yet overlapping immune mechanisms are associated with CLBP.The third study examines whether GM and cytokine profiles collected upon enrollment are linked to changes in pain and disability over six months in individuals undergoing musculoskeletal health interventions. Some microbial taxa (e.g., Coprococcus) showed modest associations with outcomes, but diversity metrics and cytokines had weak or no associations. Two GM clusters emerged (Prevotella-dominant vs. Bacteroides-enriched); while pain changes were not observed between the two groups, the Prevotella-dominant group showed greater improvement in disability. Overall, these biomarkers offered limited predictive value for clinical outcomes in the limited 6- month time window considered.Overall, the three studies explore the inflammatory landscape in CLBP and its relationship to clinical outcomes. While meaningful associations were observed, the findings also underscore the complexity and heterogeneity of CLBP. Future research should consider more dynamic and multidimensional approaches, including repeated biomarker assessments over time and integrated multi-omics models. Such strategies may better capture the temporal and mechanistic nuances of inflammation in CLBP and help advance the development of personalized, biology-informed interventions.
- 일반주제명
- Health sciences
- 일반주제명
- Physical therapy
- 일반주제명
- Immunology
- 키워드
- Gut microbiome
- 키워드
- Plasma cytokines
- 기타저자
- University of Pittsburgh Health and Rehabilitation Sciences
- 기본자료저록
- Dissertations Abstracts International. 86-11B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■1001 ▼aTonelli Enrico, Valerio.▼0(orcid)0000-0003-1925-2446
■24510▼aBeyond the Back in Chronic Low Back Pain: Investigating Gut Microbiome and Plasma Cytokine Associations With Pain and Disability
■260 ▼a[Sl]▼bUniversity of Pittsburgh▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a367 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-11, Section: B.
■500 ▼aAdvisor: Sowa, Gwendolyn;Piva, Sara R.
■5021 ▼aThesis (Ph.D.)--University of Pittsburgh, 2025.
■520 ▼aChronic low back pain (CLBP) is a pervasive and debilitating condition influenced by complex biological, psychosocial, and environmental factors. Despite its global impact, the biological underpinnings of CLBP remain insufficiently understood, limiting the effectiveness of current treatment strategies. This dissertation investigates the role of systemic inflammation, assessed through circulating cytokines and the gut microbiome (GM), in the experience and clinical progression of CLBP. Through three complementary studies, this work examines the cross-sectional and longitudinal relationships between inflammatory biomarkers, pain, and disability in individuals with CLBP, aiming to inform more individualized rehabilitation strategies.The first study examines associations between GM composition and patient-reported pain and disability in a cross-sectional cohort of 867 individuals with CLBP. The results provide novel evidence linking gut microbiota composition to pain and disability, emphasizing the relevance of specific bacterial genera over global diversity indices. The second study examines systemic inflammation by measuring plasma cytokines in 936 individuals with CLBP. It reveals that both pro-inflammatory and anti-inflammatory cytokines are associated with pain and disability, with IL-6, IL-1ra, TNF-α, and IL-10 emerging as key markers. These findings suggest that distinct yet overlapping immune mechanisms are associated with CLBP.The third study examines whether GM and cytokine profiles collected upon enrollment are linked to changes in pain and disability over six months in individuals undergoing musculoskeletal health interventions. Some microbial taxa (e.g., Coprococcus) showed modest associations with outcomes, but diversity metrics and cytokines had weak or no associations. Two GM clusters emerged (Prevotella-dominant vs. Bacteroides-enriched); while pain changes were not observed between the two groups, the Prevotella-dominant group showed greater improvement in disability. Overall, these biomarkers offered limited predictive value for clinical outcomes in the limited 6- month time window considered.Overall, the three studies explore the inflammatory landscape in CLBP and its relationship to clinical outcomes. While meaningful associations were observed, the findings also underscore the complexity and heterogeneity of CLBP. Future research should consider more dynamic and multidimensional approaches, including repeated biomarker assessments over time and integrated multi-omics models. Such strategies may better capture the temporal and mechanistic nuances of inflammation in CLBP and help advance the development of personalized, biology-informed interventions.
■590 ▼aSchool code: 0178.
■650 4▼aHealth sciences
■650 4▼aPhysical therapy
■650 4▼aImmunology
■653 ▼aChronic low back pain
■653 ▼aGut microbiome
■653 ▼aPlasma cytokines
■653 ▼aSystemic inflammation
■653 ▼aImmune mechanisms
■690 ▼a0566
■690 ▼a0982
■690 ▼a0382
■71020▼aUniversity of Pittsburgh▼bHealth and Rehabilitation Sciences.
■7730 ▼tDissertations Abstracts International▼g86-11B.
■790 ▼a0178
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17357672▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
