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A Multi-Level Intervention Using Learning and Education (MILE) to Improve Chlorhexidine Gluconate Use and Reduce Central Line- Associated Bloodstream Infections
A Multi-Level Intervention Using Learning and Education (MILE) to Improve Chlorhexidine Gl...
A Multi-Level Intervention Using Learning and Education (MILE) to Improve Chlorhexidine Gluconate Use and Reduce Central Line- Associated Bloodstream Infections

Detailed Information

자료유형  
 학위논문 서양
최종처리일시  
20260202103056
ISBN  
9798315713951
DDC  
610.73
저자명  
Kuroki, Mika.
서명/저자  
A Multi-Level Intervention Using Learning and Education (MILE) to Improve Chlorhexidine Gluconate Use and Reduce Central Line- Associated Bloodstream Infections
발행사항  
[Sl] : The University of North Carolina at Chapel Hill, 2025
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2025
형태사항  
65 p
주기사항  
Source: Dissertations Abstracts International, Volume: 86-11, Section: B.
주기사항  
Advisor: Coombs, Lorinda.
학위논문주기  
Thesis (D.N.P.)--The University of North Carolina at Chapel Hill, 2025.
초록/해제  
요약Problem: Approximately 28,000 preventable deaths in the United States result from central line-associated bloodstream infections, contributing to over $2 billion in healthcare costs. These infections primarily develop from gram-positive organisms entering the bloodstream through central venous catheters. Current infectious disease guidelines recommend daily antiseptic chlorhexidine gluconate use to reduce infection rates in individuals requiring these catheters due to elevated morbidity and mortality risks.Purpose: At an academic Southeastern U.S. hospital on an adult inpatient Bone Marrow Transplant unit, central line-associated bloodstream infection rates (2.15/1,000 device days) were higher than the hospital-wide rate (1.28/1,000 device days). Overall documented chlorhexidine gluconate adherence on the Bone Marrow Transplant unit was lower than the hospital-wide chlorhexidine gluconate adherence rate at 53.54% compared to 63.31%. Given the increased risk in this vulnerable population, this project aimed to address the low chlorhexidine gluconate adherence and elevated central line-associated bloodstream infection rates.Methods: This 12-week quality improvement project implemented the chlorhexidine gluconate Multi-level Intervention using the Learning and Education (MILE) pilot program. The program identified barriers among nursing staff and provided staff and Bone Marrow Transplant patients with evidence-based training on chlorhexidine gluconate usage and documentation. Daily chart audits were conducted to monitor adherence.Results: Overall chlorhexidine gluconate adherence increased from 53.54% in the preintervention phase to 64.82% by the end of the implementation period. Zero central line-associated bloodstream infections were detected during the first eight weeks of the study period, while two infection events occurred during the final four weeks. Overall, the Bone Marrow Transplant unit lowered the infection rate to 0.66/1,000 device days compared to the baseline of 2.15/1,000 device days.Discussion and Further Considerations: Analysis suggests that implementing the MILE program improved chlorhexidine gluconate adherence and reduced overall central line-associated bloodstream infection rates on the Bone Marrow Transplant unit. Regarding the two infection events, a hospital shortage of IV fluids in late October 2024 due to Hurricane Helene resulted in temporary practice changes to conserve resources. This included less frequent IV changes to preserve fluids, suggesting an association between the impact of natural disasters and infection rates as planetary disasters can disrupt data collection.
일반주제명  
Nursing
일반주제명  
Oncology
일반주제명  
Cellular biology
일반주제명  
Biochemistry
키워드  
Central venous catheters
키워드  
Chlorhexidine gluconate
키워드  
Stem cell transplant
키워드  
Gram-positive organisms
기타저자  
The University of North Carolina at Chapel Hill Nursing
기본자료저록  
Dissertations Abstracts International. 86-11B.
전자적 위치 및 접속  
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MARC

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■1001  ▼aKuroki,  Mika.
■24512▼aA  Multi-Level  Intervention  Using  Learning  and  Education  (MILE)  to  Improve  Chlorhexidine  Gluconate  Use  and  Reduce  Central  Line-  Associated  Bloodstream  Infections
■260    ▼a[Sl]▼bThe  University  of  North  Carolina  at  Chapel  Hill▼c2025
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2025
■300    ▼a65  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  86-11,  Section:  B.
■500    ▼aAdvisor:  Coombs,  Lorinda.
■5021  ▼aThesis  (D.N.P.)--The  University  of  North  Carolina  at  Chapel  Hill,  2025.
■520    ▼aProblem:  Approximately  28,000  preventable  deaths  in  the  United  States  result  from  central  line-associated  bloodstream  infections,  contributing  to  over  $2  billion  in  healthcare  costs.  These  infections  primarily  develop  from  gram-positive  organisms  entering  the  bloodstream  through  central  venous  catheters.  Current  infectious  disease  guidelines  recommend  daily  antiseptic  chlorhexidine  gluconate  use  to  reduce  infection  rates  in  individuals  requiring  these  catheters  due  to  elevated  morbidity  and  mortality  risks.Purpose:  At  an  academic  Southeastern  U.S.  hospital  on  an  adult  inpatient  Bone  Marrow  Transplant  unit,  central  line-associated  bloodstream  infection  rates  (2.15/1,000  device  days)  were  higher  than  the  hospital-wide  rate  (1.28/1,000  device  days).  Overall  documented  chlorhexidine  gluconate  adherence  on  the  Bone  Marrow  Transplant  unit  was  lower  than  the  hospital-wide  chlorhexidine  gluconate  adherence  rate  at  53.54%  compared  to  63.31%.  Given  the  increased  risk  in  this  vulnerable  population,  this  project  aimed  to  address  the  low  chlorhexidine  gluconate  adherence  and  elevated  central  line-associated  bloodstream  infection  rates.Methods:  This  12-week  quality  improvement  project  implemented  the  chlorhexidine  gluconate  Multi-level  Intervention  using  the  Learning  and  Education  (MILE)  pilot  program.  The  program  identified  barriers  among  nursing  staff  and  provided  staff  and  Bone  Marrow  Transplant  patients with  evidence-based  training  on  chlorhexidine  gluconate  usage  and  documentation.  Daily  chart  audits  were  conducted  to  monitor  adherence.Results:  Overall  chlorhexidine  gluconate  adherence  increased  from  53.54%  in  the  preintervention  phase  to  64.82%  by  the  end  of  the  implementation  period.  Zero  central  line-associated  bloodstream  infections  were  detected  during  the  first  eight  weeks  of  the  study  period,  while  two  infection  events  occurred  during  the  final  four  weeks.  Overall,  the  Bone  Marrow  Transplant  unit  lowered  the  infection  rate  to  0.66/1,000  device  days  compared  to  the  baseline  of  2.15/1,000  device  days.Discussion  and  Further  Considerations:  Analysis  suggests  that  implementing  the  MILE  program  improved  chlorhexidine  gluconate  adherence  and  reduced  overall  central  line-associated  bloodstream  infection  rates  on  the  Bone  Marrow  Transplant  unit.  Regarding  the  two  infection  events,  a  hospital  shortage  of  IV  fluids  in  late  October  2024  due  to  Hurricane  Helene  resulted  in  temporary  practice  changes  to  conserve  resources.  This  included  less  frequent  IV  changes  to  preserve  fluids,  suggesting  an  association  between  the  impact  of  natural  disasters  and  infection  rates  as  planetary  disasters  can  disrupt  data  collection.
■590    ▼aSchool  code:  0153.
■650  4▼aNursing
■650  4▼aOncology
■650  4▼aCellular  biology
■650  4▼aBiochemistry
■653    ▼aCentral  venous  catheters
■653    ▼aChlorhexidine  gluconate
■653    ▼aStem  cell  transplant
■653    ▼aGram-positive  organisms
■690    ▼a0569
■690    ▼a0992
■690    ▼a0379
■690    ▼a0487
■71020▼aThe  University  of  North  Carolina  at  Chapel  Hill▼bNursing.
■7730  ▼tDissertations  Abstracts  International▼g86-11B.
■790    ▼a0153
■791    ▼aD.N.P.
■792    ▼a2025
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17356887▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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