서브메뉴
검색
Neural Mechanisms for Flexible vs Rigid Navigational Decisions
Neural Mechanisms for Flexible vs Rigid Navigational Decisions
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105149
- ISBN
- 9798293823741
- DDC
- 371
- 저자명
- Grgurich, Ryan.
- 서명/저자
- Neural Mechanisms for Flexible vs Rigid Navigational Decisions
- 발행사항
- [Sl] : University of California, Los Angeles, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 151 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-03, Section: B.
- 주기사항
- Advisor: Blair, Hugh T.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Los Angeles, 2025.
- 초록/해제
- 요약Spatial navigation depends on the brain's ability to integrate internally computed self-motion cues with external landmarks to form flexible representations of space. Classical theories of the cognitive map and subsequent lesion studies have established a dissociation between hippocampal-dependent place learning and striatal response strategies, but most paradigms allow both path integration and landmark-based navigation to operate in tandem when studying these strategies. The present study introduces a novel behavioral framework that dissociates these systems, enabling direct assessment of whether path integration alone can support flexible spatial learning. By destabilizing the relationship between self-motion cues and external landmarks through continuous visual frame rotation (VC condition), we show that rats fail to form stable allocentric maps necessary for rapid reversal and novel route acquisition. In contrast, under a stable path integration (PI) condition, with or without a consistent landmark anchor, animals exhibited robust reversal performance and rapid novel route learning, demonstrating that path integration provides the scaffold essential for flexible adaptation. Chemogenetic inhibition of the anterior cingulate cortex (ACC) did not impair PI-supported reversal or novel route performance, suggesting that hippocampal computations can sustain flexible navigation when a coherent metric framework is preserved. These findings isolate the path integration system and show it is necessary for flexible spatial learning.
- 일반주제명
- Behavioral psychology
- 일반주제명
- Neurosciences
- 일반주제명
- Psychology
- 키워드
- Cognitive maps
- 키워드
- Hippocampus
- 키워드
- Path integration
- 기타저자
- University of California, Los Angeles Psychology 0780
- 기본자료저록
- Dissertations Abstracts International. 87-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008260126s2025 us c eng d■001000017359629
■00520260202105149
■006m o d
■007cr#unu||||||||
■020 ▼a9798293823741
■035 ▼a(MiAaPQ)AAI32241618
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a371
■1001 ▼aGrgurich, Ryan.
■24510▼aNeural Mechanisms for Flexible vs Rigid Navigational Decisions
■260 ▼a[Sl]▼bUniversity of California, Los Angeles▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a151 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-03, Section: B.
■500 ▼aAdvisor: Blair, Hugh T.
■5021 ▼aThesis (Ph.D.)--University of California, Los Angeles, 2025.
■520 ▼aSpatial navigation depends on the brain's ability to integrate internally computed self-motion cues with external landmarks to form flexible representations of space. Classical theories of the cognitive map and subsequent lesion studies have established a dissociation between hippocampal-dependent place learning and striatal response strategies, but most paradigms allow both path integration and landmark-based navigation to operate in tandem when studying these strategies. The present study introduces a novel behavioral framework that dissociates these systems, enabling direct assessment of whether path integration alone can support flexible spatial learning. By destabilizing the relationship between self-motion cues and external landmarks through continuous visual frame rotation (VC condition), we show that rats fail to form stable allocentric maps necessary for rapid reversal and novel route acquisition. In contrast, under a stable path integration (PI) condition, with or without a consistent landmark anchor, animals exhibited robust reversal performance and rapid novel route learning, demonstrating that path integration provides the scaffold essential for flexible adaptation. Chemogenetic inhibition of the anterior cingulate cortex (ACC) did not impair PI-supported reversal or novel route performance, suggesting that hippocampal computations can sustain flexible navigation when a coherent metric framework is preserved. These findings isolate the path integration system and show it is necessary for flexible spatial learning.
■590 ▼aSchool code: 0031.
■650 4▼aBehavioral psychology
■650 4▼aNeurosciences
■650 4▼aPsychology
■653 ▼aCognitive maps
■653 ▼aHippocampus
■653 ▼aPath integration
■653 ▼aPrefrontal cortex
■653 ▼aSpatial navigation
■690 ▼a0384
■690 ▼a0317
■690 ▼a0621
■71020▼aUniversity of California, Los Angeles▼bPsychology 0780.
■7730 ▼tDissertations Abstracts International▼g87-03B.
■790 ▼a0031
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359629▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
