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Digitally-Assisted and Artifact-Robust Next-Generation Closed-Loop Neural Interfaces
Digitally-Assisted and Artifact-Robust Next-Generation Closed-Loop Neural Interfaces
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105506
- ISBN
- 9798263328979
- DDC
- 610
- 저자명
- Mandal, Arindam.
- 서명/저자
- Digitally-Assisted and Artifact-Robust Next-Generation Closed-Loop Neural Interfaces
- 발행사항
- [Sl] : Georgia Institute of Technology, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 100 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-05, Section: B.
- 주기사항
- Advisor: Sarkar, Vivek.
- 학위논문주기
- Thesis (Ph.D.)--Georgia Institute of Technology, 2024.
- 초록/해제
- 요약Next-generation closed-loop neuromodulation systems require miniature, high-density, artifact-tolerant neural sensing, low loop-latency, and spatially selective, programmable neural stimulation. We introduce a novel digitally-assisted and artifact-robust neural stimulator and recording front-end to meet these needs of future bidirectional neuromodulation.The proposed stimulator demonstrates spatially targeted neural stimulation with suppression of driver nonideality induced common-mode (CM) artifacts in low-latency closedloop neuromodulation. The proposed approach utilizes computationally guided concurrent stimulation across multiple electrodes to achieve spatial selectivity. The stimulator architecture supports flexible storage of multiple pre-computed stimulus patterns in integrated memory, allowing rapid recall and delivery of selected patterns in response to decoded neural activity. A combination of the stimulator circuit architecture and mixed-signal current imbalance compensation techniques effectively suppress CM artifacts to below 50 mV. These techniques are demonstrated in a 180 nm HV CMOS test-chip containing 46 stimulation drivers of 26 V compliance and validated through a combination of bench, saline, and in vivo tests.Our proposed 32-channel recording analog front-end (AFE) architecture exhibits rapid recovery from intrinsic differential-mode large stimulation artifacts while delivering highresolution digitized data with ultra-low latency. The time-multiplexed AFE architecture ensures low area and power consumption, paving the way for building high-density neural interfaces. We introduce a novel technique for the correction of feedback digital-to-analog converter (DAC) non-linearities, contributing to enhanced Signal-to-Noise-and-Distortion Ratio (SNDR). Additionally, the AFE reduces the input-channel current to prevent signal quality degradation. Fabricated in a 65 nm CMOS process, the direct digitization AFE achieves 85.4 dB SNDR in a 500 Hz bandwidth, resulting in a Schreier figure of merit of 172.1 dB, which is the highest among the existing time-multiplexed neural AFEs.
- 일반주제명
- Biomarkers
- 일반주제명
- Digitization
- 일반주제명
- Spectrum allocation
- 일반주제명
- Electrodes
- 일반주제명
- Bandwidths
- 일반주제명
- Signal processing
- 일반주제명
- Electrical engineering
- 일반주제명
- Optics
- 일반주제명
- Electromagnetics
- 기본자료저록
- Dissertations Abstracts International. 87-05B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008260126s2024 us c eng d■001000017360321
■00520260202105506
■006m o d
■007cr#unu||||||||
■020 ▼a9798263328979
■035 ▼a(MiAaPQ)AAI32308036
■035 ▼a(MiAaPQ)GeorgiaTech78613
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a610
■1001 ▼aMandal, Arindam.
■24510▼aDigitally-Assisted and Artifact-Robust Next-Generation Closed-Loop Neural Interfaces
■260 ▼a[Sl]▼bGeorgia Institute of Technology▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a100 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-05, Section: B.
■500 ▼aAdvisor: Sarkar, Vivek.
■5021 ▼aThesis (Ph.D.)--Georgia Institute of Technology, 2024.
■520 ▼aNext-generation closed-loop neuromodulation systems require miniature, high-density, artifact-tolerant neural sensing, low loop-latency, and spatially selective, programmable neural stimulation. We introduce a novel digitally-assisted and artifact-robust neural stimulator and recording front-end to meet these needs of future bidirectional neuromodulation.The proposed stimulator demonstrates spatially targeted neural stimulation with suppression of driver nonideality induced common-mode (CM) artifacts in low-latency closedloop neuromodulation. The proposed approach utilizes computationally guided concurrent stimulation across multiple electrodes to achieve spatial selectivity. The stimulator architecture supports flexible storage of multiple pre-computed stimulus patterns in integrated memory, allowing rapid recall and delivery of selected patterns in response to decoded neural activity. A combination of the stimulator circuit architecture and mixed-signal current imbalance compensation techniques effectively suppress CM artifacts to below 50 mV. These techniques are demonstrated in a 180 nm HV CMOS test-chip containing 46 stimulation drivers of 26 V compliance and validated through a combination of bench, saline, and in vivo tests.Our proposed 32-channel recording analog front-end (AFE) architecture exhibits rapid recovery from intrinsic differential-mode large stimulation artifacts while delivering highresolution digitized data with ultra-low latency. The time-multiplexed AFE architecture ensures low area and power consumption, paving the way for building high-density neural interfaces. We introduce a novel technique for the correction of feedback digital-to-analog converter (DAC) non-linearities, contributing to enhanced Signal-to-Noise-and-Distortion Ratio (SNDR). Additionally, the AFE reduces the input-channel current to prevent signal quality degradation. Fabricated in a 65 nm CMOS process, the direct digitization AFE achieves 85.4 dB SNDR in a 500 Hz bandwidth, resulting in a Schreier figure of merit of 172.1 dB, which is the highest among the existing time-multiplexed neural AFEs.
■590 ▼aSchool code: 0078.
■650 4▼aBiomarkers
■650 4▼aDigitization
■650 4▼aSpectrum allocation
■650 4▼aElectrodes
■650 4▼aBandwidths
■650 4▼aSignal processing
■650 4▼aElectrical engineering
■650 4▼aOptics
■650 4▼aElectromagnetics
■690 ▼a0544
■690 ▼a0752
■690 ▼a0607
■71020▼aGeorgia Institute of Technology.
■7730 ▼tDissertations Abstracts International▼g87-05B.
■790 ▼a0078
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17360321▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.


