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Digitally-Assisted and Artifact-Robust Next-Generation Closed-Loop Neural Interfaces
Digitally-Assisted and Artifact-Robust Next-Generation Closed-Loop Neural Interfaces
Digitally-Assisted and Artifact-Robust Next-Generation Closed-Loop Neural Interfaces

상세정보

자료유형  
 학위논문 서양
최종처리일시  
20260202105506
ISBN  
9798263328979
DDC  
610
저자명  
Mandal, Arindam.
서명/저자  
Digitally-Assisted and Artifact-Robust Next-Generation Closed-Loop Neural Interfaces
발행사항  
[Sl] : Georgia Institute of Technology, 2024
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2024
형태사항  
100 p
주기사항  
Source: Dissertations Abstracts International, Volume: 87-05, Section: B.
주기사항  
Advisor: Sarkar, Vivek.
학위논문주기  
Thesis (Ph.D.)--Georgia Institute of Technology, 2024.
초록/해제  
요약Next-generation closed-loop neuromodulation systems require miniature, high-density, artifact-tolerant neural sensing, low loop-latency, and spatially selective, programmable neural stimulation. We introduce a novel digitally-assisted and artifact-robust neural stimulator and recording front-end to meet these needs of future bidirectional neuromodulation.The proposed stimulator demonstrates spatially targeted neural stimulation with suppression of driver nonideality induced common-mode (CM) artifacts in low-latency closedloop neuromodulation. The proposed approach utilizes computationally guided concurrent stimulation across multiple electrodes to achieve spatial selectivity. The stimulator architecture supports flexible storage of multiple pre-computed stimulus patterns in integrated memory, allowing rapid recall and delivery of selected patterns in response to decoded neural activity. A combination of the stimulator circuit architecture and mixed-signal current imbalance compensation techniques effectively suppress CM artifacts to below 50 mV. These techniques are demonstrated in a 180 nm HV CMOS test-chip containing 46 stimulation drivers of 26 V compliance and validated through a combination of bench, saline, and in vivo tests.Our proposed 32-channel recording analog front-end (AFE) architecture exhibits rapid recovery from intrinsic differential-mode large stimulation artifacts while delivering highresolution digitized data with ultra-low latency. The time-multiplexed AFE architecture ensures low area and power consumption, paving the way for building high-density neural interfaces. We introduce a novel technique for the correction of feedback digital-to-analog converter (DAC) non-linearities, contributing to enhanced Signal-to-Noise-and-Distortion Ratio (SNDR). Additionally, the AFE reduces the input-channel current to prevent signal quality degradation. Fabricated in a 65 nm CMOS process, the direct digitization AFE achieves 85.4 dB SNDR in a 500 Hz bandwidth, resulting in a Schreier figure of merit of 172.1 dB, which is the highest among the existing time-multiplexed neural AFEs.
일반주제명  
Biomarkers
일반주제명  
Digitization
일반주제명  
Spectrum allocation
일반주제명  
Electrodes
일반주제명  
Bandwidths
일반주제명  
Signal processing
일반주제명  
Electrical engineering
일반주제명  
Optics
일반주제명  
Electromagnetics
기타저자  
Georgia Institute of Technology.
기본자료저록  
Dissertations Abstracts International. 87-05B.
전자적 위치 및 접속  
로그인 후 원문을 볼 수 있습니다.

MARC

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■035    ▼a(MiAaPQ)AAI32308036
■035    ▼a(MiAaPQ)GeorgiaTech78613
■040    ▼aMiAaPQ▼cMiAaPQ
■0820  ▼a610
■1001  ▼aMandal,  Arindam.
■24510▼aDigitally-Assisted  and  Artifact-Robust  Next-Generation  Closed-Loop  Neural  Interfaces
■260    ▼a[Sl]▼bGeorgia  Institute  of  Technology▼c2024
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2024
■300    ▼a100  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  87-05,  Section:  B.
■500    ▼aAdvisor:  Sarkar,  Vivek.
■5021  ▼aThesis  (Ph.D.)--Georgia  Institute  of  Technology,  2024.
■520    ▼aNext-generation  closed-loop  neuromodulation  systems  require  miniature,  high-density,  artifact-tolerant  neural  sensing,  low  loop-latency,  and  spatially  selective,  programmable  neural  stimulation.  We  introduce  a  novel  digitally-assisted  and  artifact-robust  neural  stimulator  and  recording  front-end  to  meet  these  needs  of  future  bidirectional  neuromodulation.The  proposed  stimulator  demonstrates  spatially  targeted  neural  stimulation  with  suppression  of  driver  nonideality  induced  common-mode  (CM)  artifacts  in  low-latency  closedloop  neuromodulation.  The  proposed  approach  utilizes  computationally  guided  concurrent  stimulation  across  multiple  electrodes  to  achieve  spatial  selectivity.  The  stimulator  architecture  supports  flexible  storage  of  multiple  pre-computed  stimulus  patterns  in  integrated  memory,  allowing  rapid  recall  and  delivery  of  selected  patterns  in  response  to  decoded  neural  activity.  A  combination  of  the  stimulator  circuit  architecture  and  mixed-signal  current  imbalance  compensation  techniques  effectively  suppress  CM  artifacts  to  below  50  mV.  These  techniques  are  demonstrated  in  a  180  nm  HV  CMOS  test-chip  containing  46  stimulation  drivers  of  26  V  compliance  and  validated  through  a  combination  of  bench,  saline,  and  in  vivo  tests.Our  proposed  32-channel  recording  analog  front-end  (AFE)  architecture  exhibits  rapid  recovery  from  intrinsic  differential-mode  large  stimulation  artifacts  while  delivering  highresolution  digitized  data  with  ultra-low  latency.  The  time-multiplexed  AFE  architecture  ensures  low  area  and  power  consumption,  paving  the  way  for  building  high-density  neural  interfaces.  We  introduce  a  novel  technique  for  the  correction  of  feedback  digital-to-analog  converter  (DAC)  non-linearities,  contributing  to  enhanced  Signal-to-Noise-and-Distortion  Ratio  (SNDR).  Additionally,  the  AFE  reduces  the  input-channel  current  to  prevent  signal  quality  degradation.  Fabricated  in  a  65  nm  CMOS  process,  the  direct  digitization  AFE  achieves  85.4  dB  SNDR  in  a  500  Hz  bandwidth,  resulting  in  a  Schreier  figure  of  merit  of  172.1  dB,  which  is  the  highest  among  the  existing  time-multiplexed  neural  AFEs.
■590    ▼aSchool  code:  0078.
■650  4▼aBiomarkers
■650  4▼aDigitization
■650  4▼aSpectrum  allocation
■650  4▼aElectrodes
■650  4▼aBandwidths
■650  4▼aSignal  processing
■650  4▼aElectrical  engineering
■650  4▼aOptics
■650  4▼aElectromagnetics
■690    ▼a0544
■690    ▼a0752
■690    ▼a0607
■71020▼aGeorgia  Institute  of  Technology.
■7730  ▼tDissertations  Abstracts  International▼g87-05B.
■790    ▼a0078
■791    ▼aPh.D.
■792    ▼a2024
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17360321▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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