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Environmental Metal Mixtures, Body Composition, and Insulin Resistance in African Caribbean Adults: Findings from the Tobago Health Study
Environmental Metal Mixtures, Body Composition, and Insulin Resistance in African Caribbean Adults: Findings from the Tobago Health Study
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202104843
- ISBN
- 9798290953397
- DDC
- 614.4
- 서명/저자
- Environmental Metal Mixtures, Body Composition, and Insulin Resistance in African Caribbean Adults: Findings from the Tobago Health Study
- 발행사항
- [Sl] : University of Pittsburgh, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 167 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-02, Section: B.
- 주기사항
- Advisor: Sanders, Alison P.
- 학위논문주기
- Thesis (Ph.D.)--University of Pittsburgh, 2025.
- 초록/해제
- 요약Understanding the drivers of type 2 diabetes (T2D) is essential to slowing its global rise. While lifestyle and genetics play important roles, they likely do not fully explain the growing burden, highlighting environmental exposures as potential risk factors for T2D. This investigation is particularly important for African Caribbean populations, who have a high prevalence of T2D and are underrepresented in environmental health research. Historically, studies have focused on the health effects of individual metals, but recent approaches have shifted toward examining the metal mixtures to better reflect real-world conditions. Similarly, incorporating the study of metabolically important physiological characteristics like myosteatosis (fat infiltration of skeletal muscle) adds further nuance to our understanding of the environmental effects on early metabolic dysfunction. The first aim characterized urinary metal concentrations and identified sociodemographic, dietary, and lifestyle predictors of metal exposure in African Caribbean men and women from Tobago. Twelve metals were detected in nearly all participants, and metal concentration patterns differed by sex, anthropometrics, age, physical activity, sleep, and diet. The second aim assessed the relationship between urinary metal mixtures and insulin resistance, estimated by HOMA-IR, in 635 adults without T2D. Among women, higher copper and tin concentrations were associated with higher insulin resistance individually, and both metals, in addition to barium, contributed to an overall metal mixture effect on insulin resistance. No associations were observed between metals and insulin resistance among men. The third aim investigated whether myosteatosis, measured as intermuscular adipose tissue (IMAT), and modified the relationship between urinary metal concentrations and insulin resistance. In women, we found that IMAT modified the association of copper, molybdenum, thallium, and uranium, with HOMA-IR. There was also a significant interaction between the metal mixture and IMAT. No significant interactions between IMAT and metal concentrations, individually or as a mixture, were observed in men. Future research is needed to better understand the mechanisms of the effect modification of metals and insulin resistance by IMAT and how these mechanisms can be disrupted to prevent T2D development.
- 일반주제명
- Epidemiology
- 일반주제명
- Environmental health
- 일반주제명
- Physiology
- 키워드
- Body composition
- 키워드
- Metals
- 키워드
- Type 2 diabetes
- 기타저자
- University of Pittsburgh Epidemiology
- 기본자료저록
- Dissertations Abstracts International. 87-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798290953397
■035 ▼a(MiAaPQ)AAI32173190
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a614.4
■1001 ▼aPrice, Natalie F.▼0(orcid)0009-0001-1956-9374
■24510▼aEnvironmental Metal Mixtures, Body Composition, and Insulin Resistance in African Caribbean Adults: Findings from the Tobago Health Study
■260 ▼a[Sl]▼bUniversity of Pittsburgh▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a167 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-02, Section: B.
■500 ▼aAdvisor: Sanders, Alison P.
■5021 ▼aThesis (Ph.D.)--University of Pittsburgh, 2025.
■520 ▼aUnderstanding the drivers of type 2 diabetes (T2D) is essential to slowing its global rise. While lifestyle and genetics play important roles, they likely do not fully explain the growing burden, highlighting environmental exposures as potential risk factors for T2D. This investigation is particularly important for African Caribbean populations, who have a high prevalence of T2D and are underrepresented in environmental health research. Historically, studies have focused on the health effects of individual metals, but recent approaches have shifted toward examining the metal mixtures to better reflect real-world conditions. Similarly, incorporating the study of metabolically important physiological characteristics like myosteatosis (fat infiltration of skeletal muscle) adds further nuance to our understanding of the environmental effects on early metabolic dysfunction. The first aim characterized urinary metal concentrations and identified sociodemographic, dietary, and lifestyle predictors of metal exposure in African Caribbean men and women from Tobago. Twelve metals were detected in nearly all participants, and metal concentration patterns differed by sex, anthropometrics, age, physical activity, sleep, and diet. The second aim assessed the relationship between urinary metal mixtures and insulin resistance, estimated by HOMA-IR, in 635 adults without T2D. Among women, higher copper and tin concentrations were associated with higher insulin resistance individually, and both metals, in addition to barium, contributed to an overall metal mixture effect on insulin resistance. No associations were observed between metals and insulin resistance among men. The third aim investigated whether myosteatosis, measured as intermuscular adipose tissue (IMAT), and modified the relationship between urinary metal concentrations and insulin resistance. In women, we found that IMAT modified the association of copper, molybdenum, thallium, and uranium, with HOMA-IR. There was also a significant interaction between the metal mixture and IMAT. No significant interactions between IMAT and metal concentrations, individually or as a mixture, were observed in men. Future research is needed to better understand the mechanisms of the effect modification of metals and insulin resistance by IMAT and how these mechanisms can be disrupted to prevent T2D development.
■590 ▼aSchool code: 0178.
■650 4▼aEpidemiology
■650 4▼aEnvironmental health
■650 4▼aPhysiology
■653 ▼aBody composition
■653 ▼aEnvironmental exposures
■653 ▼aMetals
■653 ▼aType 2 diabetes
■690 ▼a0766
■690 ▼a0470
■690 ▼a0719
■71020▼aUniversity of Pittsburgh▼bEpidemiology.
■7730 ▼tDissertations Abstracts International▼g87-02B.
■790 ▼a0178
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359158▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
