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Advancing Dosimetry for Alpha-Emitting Radiopharmaceuticals: A Framework for 225Ac Quantification
Advancing Dosimetry for Alpha-Emitting Radiopharmaceuticals: A Framework for 225Ac Quantification
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105153
- ISBN
- 9798297981232
- DDC
- 530
- 저자명
- Jollota, Sean.
- 서명/저자
- Advancing Dosimetry for Alpha-Emitting Radiopharmaceuticals: A Framework for 225Ac Quantification
- 발행사항
- [Sl] : The University of Wisconsin - Madison, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 245 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-05, Section: B.
- 주기사항
- Advisor: DeWerd, Larry A.
- 학위논문주기
- Thesis (Ph.D.)--The University of Wisconsin - Madison, 2025.
- 초록/해제
- 요약Radiopharmaceutical therapy using alpha-emitting radionuclides holds promise for treating micrometastatic and resistant disease, yet dosimetry remains a critical challenge due to the short path length and high linear energy transfer of alpha particles. This thesis addresses the metrological gap in activity and absorbed dose standardization for alpha-emitters, with a focus on 225Ac, by developing traceable measurement techniques that enable quantitative imaging and dosimetry across preclinical and clinical applications.A drop-on-demand inkjet system was characterized for the deposition of traceable 2D imaging phantoms with sub-millimeter spatial precision. Quantitative autoradiography using the iQID imaging system demonstrated spatial resolution down to 10 μm and revealed the influence of substrate material, deposition pattern, and droplet frequency on image fidelity and activity recovery. Gold-coated nickel emerged as the most suitable substrate for achieving uniform and reproducible source geometries. Comparison of 225Ac and 241Am phantom imaging results highlighted the need for radionuclide-specific calibration strategies and underscored the importance of optimizing iQID input settings and imaging geometry for accurate quantification.To support absolute dosimetry for alpha-emitting sources, this thesis extended the use of extrapolation chamber measurements to include in-house preparation and physical characterization of 225Ac sources. Detailed investigations of self-attenuation, source uniformity, and activity quantification were conducted using digital autoradiography, alpha spectrometry, and gamma spectrometry. Monte Carlo simulations were used to model the extrapolation chamber response and validate geometric correction factors, enabling absorbed dose to air determinations. A direct comparison with Geant4-based simulations, including a research internal dosimetry platform, was performed to benchmark modeling accuracy. These experimentally derived absorbed dose measurements offer a practical foundation for validating time-integrated activity-to-absorbed dose conversion platforms used in radiopharmaceutical therapy, bridging computational estimates with traceable physical measurement.Together, these efforts provide a foundation for standardizing activity and absorbed dose quantification for alpha-emitting radionuclides used in radiopharmaceutical therapy applications. By establishing traceable fabrication and measurement procedures for both 2D imaging and extrapolation chamber absorbed dose quantification, this work contributes to the broader goal of enabling accurate and reproducible dosimetry in radiopharmaceutical therapy. The methodologies presented here serve as a pathway toward implementing calibration frameworks for alpha sources, bridging the gap between metrology and clinical practice.
- 일반주제명
- Physics
- 일반주제명
- Biophysics
- 기타저자
- The University of Wisconsin - Madison Medical Physics
- 기본자료저록
- Dissertations Abstracts International. 87-05B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■006m o d
■007cr#unu||||||||
■020 ▼a9798297981232
■035 ▼a(MiAaPQ)AAI32242675
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a530
■1001 ▼aJollota, Sean.
■24510▼aAdvancing Dosimetry for Alpha-Emitting Radiopharmaceuticals: A Framework for 225Ac Quantification
■260 ▼a[Sl]▼bThe University of Wisconsin - Madison▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a245 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-05, Section: B.
■500 ▼aAdvisor: DeWerd, Larry A.
■5021 ▼aThesis (Ph.D.)--The University of Wisconsin - Madison, 2025.
■520 ▼aRadiopharmaceutical therapy using alpha-emitting radionuclides holds promise for treating micrometastatic and resistant disease, yet dosimetry remains a critical challenge due to the short path length and high linear energy transfer of alpha particles. This thesis addresses the metrological gap in activity and absorbed dose standardization for alpha-emitters, with a focus on 225Ac, by developing traceable measurement techniques that enable quantitative imaging and dosimetry across preclinical and clinical applications.A drop-on-demand inkjet system was characterized for the deposition of traceable 2D imaging phantoms with sub-millimeter spatial precision. Quantitative autoradiography using the iQID imaging system demonstrated spatial resolution down to 10 μm and revealed the influence of substrate material, deposition pattern, and droplet frequency on image fidelity and activity recovery. Gold-coated nickel emerged as the most suitable substrate for achieving uniform and reproducible source geometries. Comparison of 225Ac and 241Am phantom imaging results highlighted the need for radionuclide-specific calibration strategies and underscored the importance of optimizing iQID input settings and imaging geometry for accurate quantification.To support absolute dosimetry for alpha-emitting sources, this thesis extended the use of extrapolation chamber measurements to include in-house preparation and physical characterization of 225Ac sources. Detailed investigations of self-attenuation, source uniformity, and activity quantification were conducted using digital autoradiography, alpha spectrometry, and gamma spectrometry. Monte Carlo simulations were used to model the extrapolation chamber response and validate geometric correction factors, enabling absorbed dose to air determinations. A direct comparison with Geant4-based simulations, including a research internal dosimetry platform, was performed to benchmark modeling accuracy. These experimentally derived absorbed dose measurements offer a practical foundation for validating time-integrated activity-to-absorbed dose conversion platforms used in radiopharmaceutical therapy, bridging computational estimates with traceable physical measurement.Together, these efforts provide a foundation for standardizing activity and absorbed dose quantification for alpha-emitting radionuclides used in radiopharmaceutical therapy applications. By establishing traceable fabrication and measurement procedures for both 2D imaging and extrapolation chamber absorbed dose quantification, this work contributes to the broader goal of enabling accurate and reproducible dosimetry in radiopharmaceutical therapy. The methodologies presented here serve as a pathway toward implementing calibration frameworks for alpha sources, bridging the gap between metrology and clinical practice.
■590 ▼aSchool code: 0262.
■650 4▼aPhysics
■650 4▼aBiophysics
■653 ▼aAbsorbed dose measurements
■653 ▼aAlpha-emitting radionuclides
■653 ▼aIonization chambers
■653 ▼aDigital autoradiography
■690 ▼a0605
■690 ▼a0786
■71020▼aThe University of Wisconsin - Madison▼bMedical Physics.
■7730 ▼tDissertations Abstracts International▼g87-05B.
■790 ▼a0262
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359659▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
