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From Melting Dynamics to Medical Diagnostics: Studies in Geochemical Kinetics
From Melting Dynamics to Medical Diagnostics: Studies in Geochemical Kinetics
From Melting Dynamics to Medical Diagnostics: Studies in Geochemical Kinetics

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자료유형  
 학위논문 서양
최종처리일시  
20260202104750
ISBN  
9798290653716
DDC  
600
저자명  
Miaou, Emily Yishiuan.
서명/저자  
From Melting Dynamics to Medical Diagnostics: Studies in Geochemical Kinetics
발행사항  
[Sl] : California Institute of Technology, 2025
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2025
형태사항  
127 p
주기사항  
Source: Dissertations Abstracts International, Volume: 87-01, Section: B.
주기사항  
Advisor: Asimow, Paul;Tissot, Francois.
학위논문주기  
Thesis (Ph.D.)--California Institute of Technology, 2025.
초록/해제  
요약This thesis investigates geochemical kinetics across different subfields, from isotope metallomics in the human body to melting dynamics in igneous petrology. Chapters II and III explore the chemical complexities of rapid mineral melting in igneous systems. An experimental-computational approach is used, with the experiments providing data that help calibrate the numerical model. This integrated strategy contributes to a comprehensive understanding of the kinetics of melting that could not be captured by either method alone. Chapter II outlines the experimental work, which includes both equilibrium and kinetic melting experiments performed on the ubiquitous igneous mineral series plagioclase. The kinetic experiments are designed to deliberately access a parameter space of disequilibrium behaviors rarely studied experimentally yet likely to be relevant in various natural settings where systems evolve too quickly to follow the predictions of equilibrium theory. Quantitative and qualitative analyses of the recovered experimental products allow us to observe unique textures and chemical gradients that arise from the interplay of thermal and chemical diffusion within the phases, coupled with phase boundary motion and associated surface reactions. Chapter III details the theory and computational methods used to develop a numerical model that describes chemical evolution of melt and crystal phases during two-component melting. Novel application of thermodynamic data is used to describe chemical behavior at the phase boundary, allowing for departure from traditional equilibrium assumptions. Results of the model bring us one step closer to the ultimate goal of understanding disequilibrium in multicomponent rock systems. Chapter IV investigates the kinetics of stable isotopes in biomedicine. Box modeling was used to simulate copper (Cu) stable isotope dynamics in the human body, allowing us to quantify the possible effects of various health conditions (e.g.,cancer, liver disease) on isotopic compositions throughout different organs. In turn, we determine whether Cu isotopes can act as diagnostic or prognostic markers for certain diseases using detection by modern mass spectrometry and provide recommendations on their potential uses in the medical field.
일반주제명  
Metals
일반주제명  
Thermodynamics
일반주제명  
Chemical elements
일반주제명  
Geochemistry
일반주제명  
Copper
일반주제명  
Scientific imaging
일반주제명  
Fractionation
일반주제명  
Energy
일반주제명  
Metabolism
일반주제명  
Liver diseases
일반주제명  
Dietary minerals
일반주제명  
Mass spectrometry
일반주제명  
Solid solutions
일반주제명  
Sodium
일반주제명  
Isotopes
일반주제명  
Liquid-solid equilibrium
일반주제명  
Kinetics
일반주제명  
Human body
기타저자  
California Institute of Technology Geological and Planetary Sciences
기본자료저록  
Dissertations Abstracts International. 87-01B.
전자적 위치 및 접속  
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MARC

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■0820  ▼a600
■1001  ▼aMiaou,  Emily  Yishiuan.
■24510▼aFrom  Melting  Dynamics  to  Medical  Diagnostics:  Studies  in  Geochemical  Kinetics
■260    ▼a[Sl]▼bCalifornia  Institute  of  Technology▼c2025
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2025
■300    ▼a127  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  87-01,  Section:  B.
■500    ▼aAdvisor:  Asimow,  Paul;Tissot,  Francois.
■5021  ▼aThesis  (Ph.D.)--California  Institute  of  Technology,  2025.
■520    ▼aThis  thesis  investigates  geochemical  kinetics  across  different  subfields,  from  isotope  metallomics  in  the  human  body  to  melting  dynamics  in  igneous  petrology.  Chapters  II  and  III  explore  the  chemical  complexities  of  rapid  mineral  melting  in  igneous  systems.  An  experimental-computational  approach  is  used,  with  the  experiments  providing  data  that  help  calibrate  the  numerical  model.  This  integrated  strategy  contributes  to  a  comprehensive  understanding  of  the  kinetics  of  melting  that  could  not  be  captured  by  either  method  alone.  Chapter  II  outlines  the  experimental  work,  which  includes  both  equilibrium  and  kinetic  melting  experiments  performed  on  the  ubiquitous  igneous  mineral  series  plagioclase.  The  kinetic  experiments  are  designed  to  deliberately  access  a  parameter  space  of  disequilibrium  behaviors  rarely  studied  experimentally  yet  likely  to  be  relevant  in  various  natural  settings  where  systems  evolve  too  quickly  to  follow  the  predictions  of  equilibrium  theory.  Quantitative  and  qualitative  analyses  of  the  recovered  experimental  products  allow  us  to  observe  unique  textures  and  chemical  gradients  that  arise  from  the  interplay  of  thermal  and  chemical  diffusion  within  the  phases,  coupled  with  phase  boundary  motion  and  associated  surface  reactions.  Chapter  III  details  the  theory  and  computational  methods  used  to  develop  a  numerical  model  that  describes  chemical  evolution  of  melt  and  crystal  phases  during  two-component  melting.  Novel  application  of  thermodynamic  data  is  used  to  describe  chemical  behavior  at  the  phase  boundary,  allowing  for  departure  from  traditional  equilibrium  assumptions.  Results  of  the  model  bring  us  one  step  closer  to  the  ultimate  goal  of  understanding  disequilibrium  in  multicomponent  rock  systems.  Chapter  IV  investigates  the  kinetics  of  stable  isotopes  in  biomedicine.  Box  modeling  was  used  to  simulate  copper  (Cu)  stable  isotope  dynamics  in  the  human  body,  allowing  us  to  quantify  the  possible  effects  of  various  health  conditions  (e.g.,cancer,  liver  disease)  on  isotopic  compositions  throughout  different  organs.  In  turn,  we  determine  whether  Cu  isotopes  can  act  as  diagnostic  or  prognostic  markers  for  certain  diseases  using  detection  by  modern  mass  spectrometry  and  provide  recommendations  on  their  potential  uses  in  the  medical  field.
■590    ▼aSchool  code:  0037.
■650  4▼aMetals
■650  4▼aThermodynamics
■650  4▼aChemical  elements
■650  4▼aGeochemistry
■650  4▼aCopper
■650  4▼aScientific  imaging
■650  4▼aFractionation
■650  4▼aEnergy
■650  4▼aMetabolism
■650  4▼aLiver  diseases
■650  4▼aDietary  minerals
■650  4▼aMass  spectrometry
■650  4▼aSolid  solutions
■650  4▼aSodium
■650  4▼aIsotopes
■650  4▼aLiquid-solid  equilibrium
■650  4▼aKinetics
■650  4▼aHuman  body
■690    ▼a0791
■690    ▼a0348
■690    ▼a0996
■71020▼aCalifornia  Institute  of  Technology▼bGeological  and  Planetary  Sciences.
■7730  ▼tDissertations  Abstracts  International▼g87-01B.
■790    ▼a0037
■791    ▼aPh.D.
■792    ▼a2025
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17358773▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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