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From Melting Dynamics to Medical Diagnostics: Studies in Geochemical Kinetics
From Melting Dynamics to Medical Diagnostics: Studies in Geochemical Kinetics
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202104750
- ISBN
- 9798290653716
- DDC
- 600
- 서명/저자
- From Melting Dynamics to Medical Diagnostics: Studies in Geochemical Kinetics
- 발행사항
- [Sl] : California Institute of Technology, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 127 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-01, Section: B.
- 주기사항
- Advisor: Asimow, Paul;Tissot, Francois.
- 학위논문주기
- Thesis (Ph.D.)--California Institute of Technology, 2025.
- 초록/해제
- 요약This thesis investigates geochemical kinetics across different subfields, from isotope metallomics in the human body to melting dynamics in igneous petrology. Chapters II and III explore the chemical complexities of rapid mineral melting in igneous systems. An experimental-computational approach is used, with the experiments providing data that help calibrate the numerical model. This integrated strategy contributes to a comprehensive understanding of the kinetics of melting that could not be captured by either method alone. Chapter II outlines the experimental work, which includes both equilibrium and kinetic melting experiments performed on the ubiquitous igneous mineral series plagioclase. The kinetic experiments are designed to deliberately access a parameter space of disequilibrium behaviors rarely studied experimentally yet likely to be relevant in various natural settings where systems evolve too quickly to follow the predictions of equilibrium theory. Quantitative and qualitative analyses of the recovered experimental products allow us to observe unique textures and chemical gradients that arise from the interplay of thermal and chemical diffusion within the phases, coupled with phase boundary motion and associated surface reactions. Chapter III details the theory and computational methods used to develop a numerical model that describes chemical evolution of melt and crystal phases during two-component melting. Novel application of thermodynamic data is used to describe chemical behavior at the phase boundary, allowing for departure from traditional equilibrium assumptions. Results of the model bring us one step closer to the ultimate goal of understanding disequilibrium in multicomponent rock systems. Chapter IV investigates the kinetics of stable isotopes in biomedicine. Box modeling was used to simulate copper (Cu) stable isotope dynamics in the human body, allowing us to quantify the possible effects of various health conditions (e.g.,cancer, liver disease) on isotopic compositions throughout different organs. In turn, we determine whether Cu isotopes can act as diagnostic or prognostic markers for certain diseases using detection by modern mass spectrometry and provide recommendations on their potential uses in the medical field.
- 일반주제명
- Metals
- 일반주제명
- Thermodynamics
- 일반주제명
- Chemical elements
- 일반주제명
- Geochemistry
- 일반주제명
- Copper
- 일반주제명
- Scientific imaging
- 일반주제명
- Fractionation
- 일반주제명
- Energy
- 일반주제명
- Metabolism
- 일반주제명
- Liver diseases
- 일반주제명
- Dietary minerals
- 일반주제명
- Mass spectrometry
- 일반주제명
- Solid solutions
- 일반주제명
- Sodium
- 일반주제명
- Isotopes
- 일반주제명
- Liquid-solid equilibrium
- 일반주제명
- Kinetics
- 일반주제명
- Human body
- 기타저자
- California Institute of Technology Geological and Planetary Sciences
- 기본자료저록
- Dissertations Abstracts International. 87-01B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■006m o d
■007cr#unu||||||||
■020 ▼a9798290653716
■035 ▼a(MiAaPQ)AAI32151326
■035 ▼a(MiAaPQ)Caltech17237
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a600
■1001 ▼aMiaou, Emily Yishiuan.
■24510▼aFrom Melting Dynamics to Medical Diagnostics: Studies in Geochemical Kinetics
■260 ▼a[Sl]▼bCalifornia Institute of Technology▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a127 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-01, Section: B.
■500 ▼aAdvisor: Asimow, Paul;Tissot, Francois.
■5021 ▼aThesis (Ph.D.)--California Institute of Technology, 2025.
■520 ▼aThis thesis investigates geochemical kinetics across different subfields, from isotope metallomics in the human body to melting dynamics in igneous petrology. Chapters II and III explore the chemical complexities of rapid mineral melting in igneous systems. An experimental-computational approach is used, with the experiments providing data that help calibrate the numerical model. This integrated strategy contributes to a comprehensive understanding of the kinetics of melting that could not be captured by either method alone. Chapter II outlines the experimental work, which includes both equilibrium and kinetic melting experiments performed on the ubiquitous igneous mineral series plagioclase. The kinetic experiments are designed to deliberately access a parameter space of disequilibrium behaviors rarely studied experimentally yet likely to be relevant in various natural settings where systems evolve too quickly to follow the predictions of equilibrium theory. Quantitative and qualitative analyses of the recovered experimental products allow us to observe unique textures and chemical gradients that arise from the interplay of thermal and chemical diffusion within the phases, coupled with phase boundary motion and associated surface reactions. Chapter III details the theory and computational methods used to develop a numerical model that describes chemical evolution of melt and crystal phases during two-component melting. Novel application of thermodynamic data is used to describe chemical behavior at the phase boundary, allowing for departure from traditional equilibrium assumptions. Results of the model bring us one step closer to the ultimate goal of understanding disequilibrium in multicomponent rock systems. Chapter IV investigates the kinetics of stable isotopes in biomedicine. Box modeling was used to simulate copper (Cu) stable isotope dynamics in the human body, allowing us to quantify the possible effects of various health conditions (e.g.,cancer, liver disease) on isotopic compositions throughout different organs. In turn, we determine whether Cu isotopes can act as diagnostic or prognostic markers for certain diseases using detection by modern mass spectrometry and provide recommendations on their potential uses in the medical field.
■590 ▼aSchool code: 0037.
■650 4▼aMetals
■650 4▼aThermodynamics
■650 4▼aChemical elements
■650 4▼aGeochemistry
■650 4▼aCopper
■650 4▼aScientific imaging
■650 4▼aFractionation
■650 4▼aEnergy
■650 4▼aMetabolism
■650 4▼aLiver diseases
■650 4▼aDietary minerals
■650 4▼aMass spectrometry
■650 4▼aSolid solutions
■650 4▼aSodium
■650 4▼aIsotopes
■650 4▼aLiquid-solid equilibrium
■650 4▼aKinetics
■650 4▼aHuman body
■690 ▼a0791
■690 ▼a0348
■690 ▼a0996
■71020▼aCalifornia Institute of Technology▼bGeological and Planetary Sciences.
■7730 ▼tDissertations Abstracts International▼g87-01B.
■790 ▼a0037
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17358773▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.


